Adalimumab

Adalimumab

Adalimumab is a drug to relieve symptoms from arthritis, intestinal inflammation, or skin inflammation. This medicine is only available in injection form and can only be given by a doctor or medical personnel under the supervision of a doctor.

Adalimumab works by inhibiting the work of substances that cause inflammation in the body. That way, signs of inflammation, such as pain, fever, and swelling will be reduced.

Adalimumab can be used as a single drug or in combination with other drugs to overcome inflammation in the following autoimmune diseases:

  • Rheumatoid arthritis , which is joint inflammation in adults that causes pain, swelling, and stiffness.
  • Juvenile idiopathic arthritis , which is arthritis in children.
  • Ankylosing spondylitis , which is chronic inflammation of the spine.
  • Psoriatic arthritis , which is joint inflammation that attacks patients with psoriasis.
  • Plaque psoriasis, which is inflammation of the skin due to psoriasis.
  • Ulcerative colitis, which is inflammation of the colon and rectum.
  • Crohn's disease, which is inflammation of the walls of the digestive system, especially the small intestine and large intestine.

Adalimumab is sometimes also used to treat hidradenitis suppurativa and uveitis in children.

In addition to relieving symptoms, the use of injectable adalimumab is also useful to slow down the development of symptoms and reduce the risk of complications from these diseases.

Adalimumab brand name: Humira

What is Adalimumab?

Group Prescription drugs
Category Disease-Modifying Anti-Rheumatic Drugs (DMARDs) / Immunosuppressants
Benefits Relieves the symptoms of inflammation in rheumatoid arthritis , juvenile idiopathic arthritis , psoriatic arthritis, plaque psoriasis, ankylosing spondylitis, ulcerative colitis, Crohn's disease, hidradenitis suppurativa, and uveitis.
Used by Adults and children aged ≥4 years
Adalimumab for pregnant and lactating women Category C: Studies on experimental animals have shown side effects on the fetus, but there are no controlled studies on pregnant women. The drug can only be used if the magnitude of the expected benefit exceeds the magnitude of the risk to the fetus. Adalimumab can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without first consulting your doctor.
Drug form Injectable liquid

Warnings Before Using Adalimumab

Adalimumab can only be used according to a doctor's prescription. There are several things that should be considered before using this medicine, among others:

  • Tell your doctor about any allergies you have. Adalimumab should not be given to patients who are allergic to this drug.
  • Tell your doctor if you are suffering from hepatitis B, optic neuritis , tuberculosis, histoplasmosis , cancer, heart failure , diabetes, aplastic anemia , neurological diseases, such as multiple sclerosis or Guillain-Barré syndrome .
  • Tell the doctor if you have had or have recently undergone phototherapy before.
  • Adalimumab should not be given to children under 2 years of age, and children under 6 years of age to treat Crohn's disease. Children should get all vaccines from the childhood immunization program, before starting treatment with adalimumab.
  • If you plan to have a vaccination or have just received a vaccination, tell your doctor that you are using adalimumab.
  • Avoid being close to people with infectious diseases that are easily contagious, such as flu or measles, during treatment with adalimumab, because this drug can make it easier for you to contract infectious diseases.
  • Consult your doctor if you plan to have vaccinations while using adalimumab.
  • If you plan to undergo dental treatment or surgery, tell the doctor that you are using adalimumab.
  • Tell your doctor if you are taking certain medications, supplements, or herbal products.
  • Tell your doctor if you are pregnant, breastfeeding, or planning to become pregnant.
  • See a doctor immediately if an allergic drug reaction, serious side effect, or overdose occurs after using adalimumab.

Dosage and Administration of Adalimumab

Adalimumab will be given by injection under the skin (subcutaneous/SC). The doctor will determine the dose of adalimumab based on the condition to be treated. Here is the explanation:

Condition: Rheumatoid arthritis

  • Adults: The dose is 40 mg, 1 time a week.

Conditions: Ankylosing spondylitis and psoriatic arthritis

  • Adults: The dose is 40 mg, 1 time a week.

Condition: Plaque psoriasis

  • Adults: Initial dose 80 mg. The treatment dose is 40 mg, once a week, treatment starts 1 week after the first dose is given.

Condition: Juvenile idiopathic arthritis

  • Children aged 4–15 years with body weight <30 kg: The dose is 20 mg per week.
  • Children aged 4–15 years with body weight >30 kg: The dose is 40 mg per week.

Conditions: Crohn's disease and ulcerative colitis in adults

  • The initial dose of 160 mg, can be given 4x40 mg in 1 day or 2x40 mg for 2 consecutive days, then continued with 80 mg, 15 days after the first dose.
  • Maintenance dose 40 mg every 2 weeks (given 29 days after the first dose). The dose should be reviewed if the patient does not improve after 8 or 12 weeks of treatment.

How to Use Adalimumab Correctly

Adalimumab will be given in the hospital. This medicine will be injected directly by a doctor or medical staff under the supervision of a doctor . The doctor will inject the drug adalimumab under the patient's skin.

Adalimumab injection cannot cure the patient's disease, but only control the symptoms. Continue the treatment as recommended by the doctor even if your condition has improved.

The use of injectable adalimumab can make the immune system decrease and make patients more susceptible to infectious diseases. You need to do routine check-ups with the doctor so that the condition can be monitored.

Adalimumab Interactions with Other Drugs

The use of adalimumab with other drugs can cause drug interaction effects, namely:

  • Increased risk of serious side effects if used with rituximab or disease modifying anti-rheumatic drugs ( DMARD ) biologics, such as abatacept and anakinra
  • Increased immunosuppressive effect if used together with tocilizumab
  • Decreased effectiveness of live vaccines, such as the BCG vaccine

Side Effects and Dangers of Adalimumab

Some side effects that may appear after using adalimumab are irritation and pain and swelling in the injection area, nausea, headache, and back pain.

Consult a doctor if the above side effects do not subside or worsen. Go to the doctor immediately in the event of a drug allergic reaction or more serious side effects, such as:

  • Severe headache , dizziness, blurred vision, fainting
  • Numbness or tingling
  • Easy bruising or bloody stools
  • A red rash on the skin that is scaly or a pus-filled lump appears
  • Symptoms of infectious diseases , such as fever, chills, frequent sweating at night, sore throat and cough that does not heal, pain when urinating, abnormal discharge
  • Liver damage that can be marked by symptoms, such as abdominal pain, severe nausea and vomiting, or jaundice
  • Symptoms of heart problems or heart failure, such as unexplained weight gain, shortness of breath, or swelling in the hands or feet
  • Chest pain, fast , slow, or irregular heartbeat
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