Albendazole

Albendazole

Albendazole is a drug that is commonly used to treat diseases caused by infections in the intestines. In addition, this drug can also be used to treat worm infections outside the intestine, such as the liver or brain. Albendazole should only be used with a doctor's prescription.

Albendazole is an anthelmintic (anthelmintic) drug. This drug works by inhibiting the absorption of sugar in the worm's body. This causes the worm to lose its energy source and eventually die.

Albendazole can be used to eradicate various types of helminth infections. Examples are tapeworm infections ( taeniasis or cysticercosis), flatworms, hookworms , roundworms ( ascariasis ), pinworms, cutaneous larva migrans , or trichuriasis.

Albendazole drug brands:  Albendazole, Vermic, Zolkaf, Zentel

What is Albendazole

group Prescription drugs
Category Antihelminthic
Benefit Overcoming worm infection
Consumed by Adults and children
Albendazole for mothers Category D:  There is evidence that the drug contains risks to the human fetus, but the benefits may outweigh the risks, eg to treat life-threatening situations. Albendazole may be slightly absorbed into breast milk. However, taking this drug while breastfeeding is considered safe and does not affect milk production. If in doubt, consult your doctor first.
Drug form Tablets, chewable tablets, chewable caplets, and suspensions

Warnings Before Taking Albendazole: 

Here are things you need to pay attention to before taking albendazole:

  • Do not take albendazole if you are allergic to this drug. Tell your doctor about any allergies you have.
  • Tell your doctor if you have or have had liver disease, bile duct obstruction, visual disturbances, blood disorders or bone marrow disease, such as agranulocytosis , granulocytopenia, aplastic anemia , or pancytopenia.
  • Do not consume alcoholic beverages while undergoing treatment with albendazole because it can cause liver problems.
  • Tell your doctor that you are on treatment with albendazole, if you are going to have surgery, including dental surgery.
  • Tell the doctor if your child is taking any other medications, including supplements and herbal products, to anticipate drug interactions.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy. Use effective birth control to prevent pregnancy during treatment with albendazole.
  • See your doctor right away if you have an overdose, drug allergic reaction , or a more serious side effect after taking albendazole.

Albendazole Dosage and Rules 

The doctor will determine the dose and duration of treatment according to the patient's condition and the dosage form of albendazole. Here is the explanation:

Condition: Cysticercosis

  • Adults weighing <60 kg: 15 mg/kgBW Duration of treatment is 8–30 days. The maximum dose is 800 mg per day.
  • Adults weighing 60 kg: 400 mg, 2 times daily, for 8–30 days.

In treating cysticercosis that attacks the brain, the doctor will give additional drugs along with albendazole, such as anticonvulsants or steroids.

Condition: Echinococcosis

  • Adults weighing <60 kg: 15 mg/kg per day, divided into 2 doses. The maximum dose is 800 mg per day.
  • Adults weighing 60 kg: 400 mg, 2 times daily, for 28 days.

The duration of treatment for 28 days was 3 cycles, with a gap of 14 days without taking medication between cycles.

Conditions: Ascariasis, trichuriasis, hookworm infection , or pinworm infection

  • Adults and children >2 years : 400 mg, as a single dose.
  • Children 1–2 years of age: 200 mg, as a single dose. The maximum dose is 200 mg.

Condition: Liverworm infection or opisthorchiasis

  • Adult: 400 mg, 2 times daily, for 3 days. The maximum dose is 800 mg per day or 1,200 mg for 3 days. Do not forget to check with the doctor after 1 month of treatment.

Condition: Giardiasis

  • Children aged 1–12 years : 400 mg, once daily, for 5 days. The maximum dose is 400 mg per day or 2,000 mg for 5 days.

Condition: Cutane o us larva migran

  • Adult: 400 mg, once daily, for 1–3 days.

How to Take Albendazole Correctly

Be sure to read the instructions on the medicine package and follow the doctor's instructions for taking albendazole. Do not increase or decrease the dose without the doctor's permission.

Do not exceed or reduce the duration of use of albendazole as recommended by your doctor. Stopping medication prematurely can make the infection recur or more difficult to treat.

If you have an intestinal worm infection, albendazole should be taken on an empty stomach. If you have a worm infection outside the intestine, take albendazole with food, especially one that is high in fat .

If you have trouble swallowing, albendazole can be crushed or chewed first.

Make sure to carry out the control according to the schedule given by the doctor. If you are on long-term albendazole treatment, you may be asked to have medical tests, especially liver function tests, every 2 weeks. Follow the control schedule prescribed by the doctor.

Store albendazole at room temperature, in a dry place, and away from direct sunlight. Keep this medicine out of reach of children.

Albendazole Interactions with Other Drugs

Interactions that can occur if albendazole is taken with certain drugs include:

  • Increased risk of albendazole side effects when used with praziquantel , dexamethasone, or cimetidine
  • Decreased effectiveness of albendazole when used with carbamazepine , phenobarbital, phenytoin, or ritonavir

In addition, consuming grapefruit products while taking albendazole may increase the risk of side effects.

Side Effects and Dangers  of Albendazole

The following are possible side effects after taking albendazole:

  • Nauseous
  • Vomit
  • Stomach ache
  • Headache
  • Dizzy
  • Hair loss (temporary)

Consult a doctor if these side effects do not go away or get worse. See your doctor immediately if you have an allergic reaction to the drug, which can be characterized by an itchy, swollen rash, swollen eyes and lips, or difficulty breathing.

In addition, you should also go to the doctor or the emergency room immediately if you experience more serious side effects, such as:

  • Headaches that don't go away
  • Visual disturbance
  • Stomach pain
  • Jaundice
  • Dark urine
  • Tired easily
  • Easy bruising or bleeding
  • The appearance of signs of infection, such as fever, sore throat, and chills
  • Stiff neck
  • Confusion
  • Seizure
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