Albumin is  an intravenous fluid used to treat hypoalbuminemia , which is low levels of albumin in the blood. Albumin is also used to treat hypovolemic shock from severe injury or burns .

Albumin is the main protein in human blood. Naturally, this protein is produced by the liver. Albumin infusion will increase albumin levels in the blood.

Albumin can increase blood concentration, so that fluid outside the blood vessels will move into the blood vessels. That way, the volume of plasma and pressure in the blood vessels will increase, so that shock can be overcome.

This infusion is also used in the treatment of acute liver failure, jaundice of the newborn (neonatal hyperbilirubinemia), or acute respiratory distress syndrome ( ARDS ).

Albumin trademarks:  Albumep, Albumin Inj. 20% - GCC, Albuminar 5, Albunate 25, Albapure 20, Albunorm 25%, Human Albumin Grifols 20%, Human Albumin 20% Behring, Kedrialb, Octalbin 5%, Plasbumin 25, Zenalb 20

What is  Albumin

group Prescription drugs
Category Infusion fluid
Benefit Treat hypovolemic shock and hypoalbuminemia
Used by Adults and children
Albumin for pregnant and lactating women Category C:  Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus.

It is not known whether albumin can be absorbed through breast milk or not. If you are breastfeeding, do not use this medicine without telling your doctor.

Drug form Infusion

Precautions  Before Using Albumin

Albumin should only be used as prescribed by a doctor. Here are some things you need to pay attention to before using albumin:

  • Tell your doctor about any allergies you have. Albumin infusion should not be given to patients who are allergic to latex or any of the ingredients in this infusion.
  • Tell your doctor if you have or have ever had severe anemia , heart failure , hypertension, hemophilia , pulmonary edema, kidney disease , or are unable to urinate.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor if you are taking any other medicines, including supplements, or herbal products.
  • See your doctor right away if you have an overdose, drug allergic reaction, or a more serious side effect after using albumin.

Dosage and Rules for Use of albumin

The doctor will give the dose and determine the length of treatment according to the patient's condition, response, and age. The following is the distribution of albumin doses based on their intended use:

Goal: Overcome acute hypovolemic shock

  • Adult: 25 grams, at an infusion rate of 5 ml per minute (for 5% solution) or 1-2 ml per minute (for 20% solution). During the administration of albumin infusion, the doctor will monitor the patient's response and condition.
  • Children: 1 gram/kg, infusion rate of 5 ml per minute (for 5% solution) or 1-2 ml per minute (for 20% solution).

Goal: Treat hypoalbuminemia

  • Adults: . Maximum dose: 2 grams/kg body weight daily, with an infusion rate of 5 ml per minute (for 5% solution) or 1-2 ml per minute (for 20% solution).

Objective: To treat hyperbilirubinemia in newborns

  • Newborns: 1 gram/kg, given before exchange transfusion, at an infusion rate of 5 ml per minute (for 5% solution) or 1–2 ml per minute (for 20% solution).

Goal:  Overcoming acute respiratory distress syndrome (ARDS)

  • Adult: 25 grams every 8 hours given by infusion over 30 minutes for 3 days.

How to Use Albumin Correctly

Albumin can only be given by  a doctor or medical personnel under the supervision of a doctor. Albumin fluid will be injected into a vein through an IV.

Your doctor will also check and monitor your breathing, pulse, blood pressure, electrolyte levels, and kidney function while you are taking albumin.

Always consume enough water to reduce the risk of dehydration and impaired kidney function during treatment with albumin.

Albumin Interactions with Other Drugs

There are several drug interaction effects that can occur if albumin is used with other drugs. If albumin is given with other sterile fluids, the risk of hemolysis or destruction of blood cells increases.

In addition, its use with ACE inhibitors can increase the risk of fatal side effects.

Albumin Side Effects and Dangers

Side effects that can arise after consuming albumin are:

  • Nausea or vomiting
  • Fever or chills
  • A burning sensation around the face, neck, or chest ( flushing )
  • Fast heart rate

Tell your doctor if the symptoms mentioned above don't go away or get worse. See your doctor right away if you have an allergic reaction to a medication or experience more serious side effects, such as:

  • Headache, blurred vision, or ringing in the ears
  • Pale or sweaty skin
  • Confusion or anxiety
  • Chest pain , shortness of breath, cough with foamy phlegm
  • Irregular heartbeat
  • Dizziness so heavy that you want to faint
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