Alfentanil is a medication to relieve moderate to severe pain, especially during the installation of a breathing apparatus and ventilator. This drug is also used in general or general anesthesia procedures.

Alfentanil is an opioid painkiller  that works by blocking the transmission of pain signals to the central nervous system, so the body does not feel pain. Alfentanil is available in injectable form and should only be used under the supervision of a doctor in a hospital.

Alfentanil trademark: -

What is Alfentanil

group Prescription drugs
Category Opioid painkillers
Benefit Relieves moderate to severe pain when a person is on a breathing apparatus and ventilator and is used in general or general anesthesia procedures
Used by Adults, children and seniors
Alfentanil for pregnant and lactating women Category C: Animal studies have shown adverse effects on the fetus, but there have been no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Alfentanil may be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor.

Drug form Inject

Precautions Before Using Alfentanil

Alfentanil will be given by a doctor or medical officer under the supervision of a doctor in a hospital. There are several things you need to know before undergoing treatment with alfentanil, namely:

  • Tell your doctor about your history of allergies. Alfentanil should not be given to patients who are allergic to this drug.
  • Alfentanil should not be given to patients who have severe respiratory distress or who are experiencing increased intracranial pressure .
  • Tell your doctor if you are addicted to alcohol or drug abuse .
  • Tell your doctor if you have kidney disease, heart disease, bradycardia (slow heart rate), low blood pressure (hypotension), lung or respiratory tract disease, or have had a head injury .
  • Tell your doctor if you are taking any supplements, herbal products, or other medications, including MAOIs .
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Alfentanil will be given in the hospital, tell your doctor immediately if you have an allergic reaction to the drug , serious side effects, or an overdose after alfentanil injection.

Alfentanil Dosage and Rules

The doctor will determine the dose and duration of use of alfentanil according to the intended use, age, and condition of the patient.

In general, the following is the dose of alfentanil in adults according to its intended use:

Goal: Relieve pain during installation of breathing apparatus and ventilator

  • Initial dose: 3–8 mcg/kgBW
  • Maintenance dose: 3-5 mcg/kgBW by infusion at a rate of 0.5-1 mcg mv/kgBW per minute.

Purpose: To induce or initiate general anesthesia or general anesthesia

  • Initial dose: 130–245 mcg/kg by slow injection over 3 minutes.
  • Maintenance dose : 0.5–1.5 mcg/kgBW per minute administered during the surgical procedure

For elderly patients, the dose of alfentanil will be started with the lowest dose, then the dose can be increased if needed.

How to Use Alfentanil Correctly

Alfentanil injection will be given by a doctor or medical officer under the supervision of a doctor in a hospital. The drug will be injected into a vein (Intravenous / IV), or put into an IV infusion as recommended by the doctor.

During the alfentanil injection, the doctor will closely monitor the patient's breathing, blood pressure, or heart rate. Follow the doctor's advice and recommendations before, during, and after the alfentanil injection procedure.

Interactions of Alfentanil with Other Drugs

There are several drug interactions that can occur when alfentanil is used with other medicines, including:

  • Increased risk of prolonging respiratory depression if used with ketoconazole , ritonavir, erythromycin , diltiazem, or cimetidine
  • Increased risk of fatal side effects when used with barbiturate , benzodiazepine, or antipsychotic drugs
  • Increased levels of propofol in the blood
  • Increased risk of bradycardia or hypotension with beta-blocking drugs
  • Increased risk of slow heart rate and cardiac arrest when used with muscle relaxants
  • Increased risk of serotonin syndrome if used with MAOI . drugs

Side Effects and Dangers of Alfentanil

Alfentanil will be administered in a hospital under close monitoring. There are some side effects that can occur after alfentanil injection. These side effects are:

  • Heart rhythm disturbances ( arrhythmias ), slow or fast heart rate
  • High blood pressure ( hypertension ) or even hypotension
  • Nausea or vomiting
  • Stop breathing
  • Movement disorders
  • Excessive sweating or feeling warm and hot ( flushing )
  • Weakness, excessive tiredness, restlessness, or seizures

The doctor will treat the patient if the patient experiences these side effects during and after the alfentanil injection.

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