Alogliptin is a drug to lower blood sugar levels in people with type 2 diabetes mellitus. This drug can be used alone or in combination with other antidiabetic drugs.

Alogliptin works by increasing the production of insulin, a hormone that functions to optimize the absorption of blood sugar into the body's cells. This medicine can also reduce the amount of sugar produced by the liver. By working alogliptin, blood sugar levels can be reduced.

Alogliptin cannot be used in people with type 1 diabetes or in diabetic ketoacidosis.

Alogliptin trademark: Nesina

What is Alogliptin

group Prescription drugs
Category Antidiabetic
Benefit Lowering blood sugar levels in people with type 2 diabetes mellitus
Consumed by Mature
Alogliptin for pregnant and lactating women Category B: Animal studies have not demonstrated a risk to the fetus, but there are no controlled studies in pregnant women.

It is not known whether alogliptin is absorbed into breast milk or not. Consult a doctor before using this medication if you are breastfeeding.

Drug form Tablet

Precautions Before Taking Alogliptin

Before taking alogliptin, you need to pay attention to the following:

  • Do not take alogliptin if you are allergic to this drug.
  • Tell your doctor if you have or are currently suffering from kidney disease, liver disease, heart disease, pancreatitis , or  gallstones .
  • Tell your doctor if you are on  dialysis .
  • Do not drive a vehicle or operate equipment that requires caution after taking alogliptin, as this medicine may cause dizziness or drowsiness.
  • Do not consume alcoholic beverages while undergoing treatment with alogliptin, because it can increase the risk of side effects. Tell your doctor if you are having trouble reducing alcohol consumption or  are addicted to alcohol .
  • Do not give alogliptin to children under 18 years of age.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor if you are taking certain medications, supplements, or herbal products, to anticipate drug interactions.
  • See your doctor immediately if you have an allergic drug reaction , serious side effect, or overdose, after taking alogliptin.

Dosage and Rules of Use Alogliptin

The dose of alogliptin will be adjusted according to the patient's condition. The usual dose of alogliptin is 25 mg once daily, either as a single treatment or as an adjunct.

How to Take Alogliptin Correctly

Follow the doctor's advice and read the instructions on the medicine package before taking alogliptin. Do not reduce, increase, or stop medication without a doctor's direction.

Alogliptin can be taken before or after meals. Try to take alogliptin at the same time every day to get the maximum benefit.

Alogliptin needs to be taken regularly and in the long term. You will be asked to undergo regular blood sugar tests to monitor your condition and your body's response to treatment. Make sure to carry out the control according to the schedule given by the doctor.

While taking alogliptin, tell your doctor if you have serious injury, fever, or symptoms of infection, such as cough, runny nose, diarrhea, and sore throat. These conditions can affect blood sugar levels. If necessary, the doctor will adjust the dose of alogliptin according to your condition.

To increase the effectiveness of alogliptin in controlling blood sugar, you also need to undergo a healthy diet and regular exercise. If necessary, consult with your doctor about the right diet, type of food , and exercise for you.

If you forget to take alogliptin, take the drug as soon as you remember if the break with the next schedule is not too close. If it is close, ignore the missed dose and do not double the next dose.

Store alogliptin at room temperature. Do not store it in a humid place or in direct sunlight.

Interaction of Alogliptin with Other Drugs

Taking alogliptin together with a sulfonylurea, thiazolidinedione, or insulin, can affect blood sugar levels. If used simultaneously, these drugs will cause interactions in the form of an increased risk of hypoglycemia .

In addition, alogliptin can also interact with other drugs. Effects that can occur include:

  • Increased risk of angioedema if used with ACE inhibitor drugs, such as captopril
  • Increased risk of developing blood sugar instability if used with quinolone drugs, such as ciprofloxacin or levofloxacin
  • Decreased effectiveness of alogliptin when used with corticosteroids or birth control pills

Side Effects and Dangers of Alogliptin

There are several side effects that can occur after taking alogliptin, including:

  • Headache
  • Stomach ache
  • Diarrhea
  • Cold symptoms, such as stuffy nose, sore throat, or stuffy nose

Check with a doctor if the complaints mentioned above do not go away or get worse. In addition, you should also see a doctor immediately if you experience an  allergic drug reaction  or experience more serious side effects, such as:

  • Severe joint pain
  • Blisters on the skin that are filled with fluid
  • Pancreatitis, which can be characterized by severe abdominal pain that radiates to the back, nausea, vomiting, or fever
  • Heart problems, characterized by shortness of breath, weight gain, or swelling in the legs or feet
  • Liver disorders, characterized by upper abdominal pain, fatigue, dark urine, or jaundice

If you take alogliptin with other antidiabetic drugs, the risk of hypoglycaemic side effects is higher. Hypoglycemia can be characterized by hunger, cold sweats, or shaking.

If you experience symptoms of hypoglycemia, immediately consume sugary foods or drinks that are easy to digest, such as candy, honey, or sweetened tea. However, if the complaint does not improve, immediately visit a doctor or emergency room at the nearest hospital.

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