Aminolevulinic acid is a drug used in conjunction with photodynamic therapy to treat a wide variety of skin problems. This drug can also be used to help when doctors operate on gliomas on the brain or spine.
Aminolevulinic acid in the form of a gel is a photosensitizing agent. This drug will enter the abnormal skin cells and make the cells more sensitive to light from photodynamic therapy. When exposed to these rays, the cells that are entered by aminolevulinic acid will die.
Skin problems that can be treated with a combination of aminolevulinic acid and photodynamic therapy include actinic keratosis , warts, basal cell carcinoma, squamous cell carcinoma, acne, condyloma acuminata , and lichen planus .
Meanwhile, aminolevulinic acid in the form of an oral solution is an optical imaging agent . This drug works by making the glioma tissue appear to glow red, making it easy to detect and operate.
Trademarks of aminolevulinic acid: -
What is Aminolevulinic Acid
|Category||Photosensitizing agent for topical drugs and optical imaging agent for oral drugs|
|Benefit||Helps treat actinic keratosis, warts, basal cell carcinoma, acne, condyloma acuminata, and lichen planus and as an adjunct in glioma surgery|
|Aminolevulinic acid for pregnant and lactating women||
Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.
Drugs should only be used if the expected benefit outweighs the risk to the fetus.
Aminolevulinic acid is not known to be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without telling your doctor.
|Drug form||Oral gels and solutions|
Precautions Before Using Aminolevulinic Acid
Aminolevulinic acid is given by a doctor or medical officer according to the doctor's instructions. Note the following points before using aminolevulinic acid:
- Tell your doctor if you are allergic to the aminolevulinic acid, porphyrins, or phosphatidylcholine in soybeans. Aminolevulinic Acid should not be used by patients who are allergic to this drug.
- Tell your doctor if your skin is sensitive to sunlight. Aminolevulinic Acid should not be used by patients with these conditions.
- Tell your doctor if you have or have had porphyria , liver disease, kidney disease , or a blood-clotting disorder.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
- Tell your doctor if you are taking any other medications, including supplements, or herbal products.
- Protect the skin from exposure to sunlight and bright lights for 24 hours before and 48 hours after aminolevulinic acid use, for example by wearing a closed shirt and a wide hat. This is done to prevent the occurrence of side effects due to treatment.
- Tell your doctor that you are taking aminolevulinic acid if you plan to have laboratory tests or other medical procedures.
- See your doctor right away if you have an allergic reaction, overdose, or serious side effect.
Aminolevulinic Acid Dosage and Rules
The dose of aminolevulinic acid will be adjusted according to the patient's condition. The following are general doses of aminolevulinic acid based on their treatment goals:
Goal: Remove glioma
Drug form: Oral solution
- Adult: The dose for patients suspected of having grade III or IV glioma is 20 mg/kg, taken 2–4 hours before induction of anesthesia.
Goal: Treat skin problems
Drug form: Gel
- Adults: The dose will be given by a doctor or other medical personnel under the supervision of a doctor.
How to Use Aminolevulinic Acid Correctly
Aminolevulinic acid in the form of a gel will be applied to problem areas of the skin by a doctor or medical officer according to the doctor's directions. Meanwhile, aminolevulinic acid in the form of an oral solution needs to be taken 2-4 hours before glioma surgery.
As long as you are taking aminolevulinic acid, your doctor will monitor your condition closely. Be sure to follow the schedule of health checks given by the doctor. Regular health checks are carried out to ensure effective treatment and monitor side effects that may occur.
Aminolevulinic Acid Interactions with Other Drugs
Increased sensitivity to bright light and an increased risk of side effects may occur if aminolevulinic acid is used with the following medicines:
- John's Wort . Supplements
- Antibiotics or sulfa drugs , such as demeclocyline, doxycycline, minocycline, minocycline, oxytetracycline, tetracycline, sulfisoxazole or sulfamethoxazole
- diuretics , such as bendroflumethiazide, chlorthalidone, indapamide , hydrochlorothiazide, methyclothiazide, or metolazone
- sulfonylurea-type oral antidiabetic drugs, such as chlorpropamide, glimepiride , glipizide, glyburide, tolazamide, or tolbutamide
- Antipsychotic medications , such as fluphenazine, or perphenazine
- Nausea or vomiting medications, such as chlorpromazine
Aminolevulinic Acid Side Effects and Dangers
Side effects that may arise after using aminolevulinic acid are:
- Treated skin feels sore, burning, tingling, prickling, or numb.
- The treated skin darkens or becomes lighter than the surrounding skin area
- Swollen treated skin
- Skin treated with bumps, redness, and itching
- Nausea or vomiting
- Temporary memory loss, confusion, or disorientation
- Abnormal liver function results that usually occur up to 6 weeks after taking aminolevulinic acid
Call your doctor if the above side effects don't get better or get worse. Call your doctor right away if you have an allergic reaction to a drug or a more serious side effect, such as:
- Feeling like you're going to faint
- Skin rash accompanied by blisters
- Difficulty speaking or understanding what other people are talking about