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Amitriptyline is a drug to treat depressive symptoms i. In addition, this drug can also be used to treat nerve pain (neuropathy), migraines, and nocturnal enuresis (wetting the bed) in children.

Amitriptyline belongs to the class of tricyclic antidepressants. This drug works by increasing levels of a natural chemical in the brain that plays a role in stabilizing mood. That way, the symptoms of depression will subside.

Amitriptyline trademarks: Amitriptyline, Amitriptyline Hydrochloride, Amitriptyline HCl.

What is Amitriptyline

group Prescription drugs
Category Tricyclic antidepressants
Benefit Overcoming depression, nerve pain, migraines, and bed-wetting in children
Consumed by Adults, seniors, and children aged 6 years


Amitriptyline for pregnant and lactating women

Category C:  Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Amitriptyline is absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug form Tablet

Precautions Before Taking Amitriptyline

Amitriptyline should only be used according to a doctor's prescription. The following are things you need to pay attention to before taking amitriptyline:

  • Tell your doctor about any allergies you have. Amitriptyline should not be given to people who are allergic to this drug or to other tricyclic antidepressant drugs, such as nortriptyline.
  • Tell your doctor if you have used an MAOI class of drugs in the last 14 days , such as isocarboxazid or selegiline. Amitriptyline should not be used if you are or have recently taken this medicine.
  • Tell your doctor if you have recently had a heart attack. Amitriptyline should not be used in patients who have recently developed the condition.
  • Tell your doctor if you have or have had porphyria , kidney disease, respiratory problems, liver disease, hyperthyroidism , enlarged prostate, glaucoma , seizures, diabetes, paralytic ileus , or head injury.
  • Tell your doctor if you have or are currently experiencing psychosis , bipolar disorder, schizophrenia , or have ever attempted suicide.
  • Tell your doctor if you have or are currently suffering from cardiovascular disease, such as coronary heart disease , stroke, tachycardia , or heart rhythm disturbances ( arrhythmias ).
  • Perform regular check-ups according to the schedule set by the doctor during treatment with amitriptyline. Go to the doctor immediately if you feel the urge to hurt yourself or commit suicide.
  • Do not consume alcoholic beverages while undergoing treatment with amitriptyline, because it can cause fatal side effects.
  • Do not immediately engage in activities that require alertness, such as driving a vehicle or operating heavy machinery, after taking amitriptyline, as this drug can cause drowsiness and dizziness.
  • Avoid prolonged exposure to the sun after taking amitriptyline, as this medication can make the skin more prone to sunburn . Use sunscreen when you are outdoors during the day.
  • Tell your doctor if you are taking any other medications, including supplements and herbal products, in case of unwanted drug interactions.
  • Tell your doctor if you are pregnant, planning a pregnancy, or breastfeeding.
  • Tell your doctor that you are taking amitriptyline before having any surgery, including dental surgery.
  • Tell your doctor right away if you have an allergic reaction to any medication, serious side effects, or an overdose after taking amitriptyline.

Dosage and Instructions for Use of Amitriptyline

The dose of amitriptyline is different for each patient. The doctor will give the dose and determine the duration of treatment according to the patient's age and condition.

The following is a breakdown of amitriptyline doses based on the conditions being treated:

Condition: Depression

  • Adult: Initial dose 25 mg, 2 times daily for 2 weeks to 6 months. The dose may be increased gradually to 50–150 mg per day in divided doses.
  • Elderly: 10–25 mg per day, taken at night. The dose can be increased gradually to 100–150 mg per day, according to the patient's response to treatment.

Condition: Neuropathic pain and migraine prevention

  • Adult: Initial dose 10–25 mg daily, at night. The dose may be increased every 3–7 days according to the patient's response. The recommended dose is 25–75 mg per day.
  • Elderly: Initial dose 10–25 mg daily, at night. The dose can be increased gradually, but be careful when using doses above 75 mg.

Condition: Enuresis in children

  • Children 6–10 years: 10–20 mg per day.
  • Children 11–16 years: 25–50 mg per day, at bedtime. Treatment should not be more than 3 months.

How to Take Amitriptyline Correctly

Follow your doctor's advice and read the instructions on the amitriptyline package before starting to take it.

Amitriptyline can be taken before or after meals. Swallow the amitriptyline tablet with water.

Do not stop treatment without consulting your doctor first. Stopping the drug suddenly has the potential to worsen the patient's condition and cause withdrawal symptoms, such as headaches, fatigue, and difficulty sleeping.

Take amitriptyline at the same time each day to maximize treatment. If you forget to take this medicine, take it immediately if it is not close to the schedule for the next drug consumption. If it is close, ignore the missed dose and do not double the dose on the next schedule of consumption.

Store amitriptyline in a cool place and away from direct sunlight. Keep medicine out of reach of children.

Amitriptyline Interactions with Other Drugs

Interaction effects that can occur if you use amitriptyline at the same time as other medicines are:

  • Increased risk of developing serotonin syndrome , which can be fatal when used with monoamine oxidase inhibitors (MAOIs), such as isocarboxazid
  • Increased risk of arrhythmias if used with cisapride , quinidine, amiodarone , or antihistamine drugs
  • Increased risk of side effects from barbiturates or drugs that depress the central nervous system
  • Decreased effectiveness of antihypertensive drugs such as reserpine, clonidine , or methyldopa
  • Increased risk of developing hypokalemia if used with diuretic drugs , such as furosemide
  • Increased blood levels of amitriptyline when used with cimetidine, methylphenidate , antipsychotic drugs, calcium antagonist drugs , or antifungal drugs
  • Increased risk of developing delirium when used with disulfiram
  • Increased risk of side effects on the heart when used with adrenaline, phenylephrine , or ephedrine

Side Effects and Dangers of Amitriptyline

There are several side effects that can occur after taking amitriptyline, including:

  • Drowsiness
  • Dizzy
  • Dry mouth
  • Blurred vision
  • Constipation or diarrhea
  • Weight gain
  • Difficult to urinate
  • The skin is more prone to sunburn ( sunburn )
  • Stomach pain, nausea, or vomiting
  • Itching or skin rash
  • Pain or swelling in the breast (men or women)
  • Decreased libido or sexual arousal

Consult a doctor if the above complaints do not go away or get worse. Call your doctor right away if you have an allergic reaction to a drug or a more serious side effect, such as:

  • Easy bruising or bleeding
  • Shiver
  • Severe stomach ache
  • Changes in behavior, confusion, or hallucinations
  • Strange or unusual thoughts appear
  • Dizzy like I'm about to faint
  • Chest pain
  • Stiff muscles
  • Heart beat
  • The appearance of signs of blockage of blood vessels, such as numbness and weakness that occurs suddenly, swelling or redness accompanied by pain in the arms or legs
  • The appearance of signs of infection, such as fever, chills, sore throat, or thrush
  • Seizure
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