Anagrelide is a drug to treat thrombocythemia or thrombocytosis, namely high blood platelets or platelets due to disorders of the bone marrow. That way , the risk of forming blood clots (thrombosis) can be lowered.
Anagrelide is an antiplatelet drug. This drug will decrease the production and number of platelets by preventing the maturation of megakaryocyte stem cells in the bone marrow. This drug should not be used carelessly and must be according to a doctor's prescription.
Anagrelide trademarks : Agrylin, Thromboreductin
What is Anagrelide
|Benefit||Treat thrombocythemia or thrombocytosis|
|Consumed by||Children aged ≥7 years to adults|
|Anagrelide for pregnant and lactating women||Category C: Studies in animal studies have shown an adverse effect on the fetus, but there have been no controlled studies in pregnant women. The drug should only be used if the expected benefit outweighs the risk to the fetus. It is not known whether Anagrelide is absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.|
Precautions Before Taking Anagrelide
Anagrelide should only be taken as prescribed by a doctor. Note the following points before taking anagrelide:
- Tell your doctor about any allergies you have. Anagrelide should not be given to patients who are allergic to this drug.
- Tell your doctor if you have or have had liver disease, kidney disease, blood clotting disorders, low potassium levels ( hypokalemia ), heart disease, or heart rhythm disturbances, such as QT prolongation or bradycardia .
- Tell your doctor if you are taking certain medications, supplements or herbal products.
- Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
- Tell your doctor that you are taking anagrelide if you plan to have surgery, including dental surgery.
- Do not drive a vehicle or do activities that require alertness while taking anagrelide, because this drug can cause dizziness.
- Do not consume alcoholic beverages or grapefruit while taking anagrelide, as this can increase the risk of side effects.
- See your doctor right away if you experience an allergic drug reaction, serious side effect, or overdose after taking anagrelide.
Dosage and Rules for Use of Anagrelide
The dose of anagrelide given by doctors can be different for each patient, depending on the patient's age and response to the drug. The following are common doses of anagrelide to treat thrombocythemia or essential thrombocytosis:
Initial dose of 1 mg per day, divided into 2 times consumption. The dose will be increased by a maximum of 0.5 mg per week until the platelet count is within normal limits. Maintenance dose 1–3 mg per day. The maximum dose per administration is 2.5 mg and the maximum dose per day is 10 mg.
Children aged 7 years
Initial dose of 0.5 mg per day for the first week. The dose is increased by 0.5 mg per week until the platelet count is within normal limits. Maintenance dose 1–3 mg per day. The maximum dose per administration is 2.5 mg and the maximum dose per day is 10 mg.
How to Take Anagrelide Correctly
Follow your doctor 's advice and read the instructions on the medicine package before taking anagrelide. Do not increase or decrease the dose without consulting your doctor.
Take anagrelide regularly at the same time every day to maximize the effect of the drug. Anagrelide can be taken with or without food. Take anagrelide whole with the help of a glass of water. Do not crush or chew the medicine.
Do not stop taking anagrelide even though your condition has improved, unless advised by your doctor. Stop taking the drug can make platelet levels increase again
If you forget to take anagrelide, take this drug immediately if the interval between the next consumption schedule is not too close. If it is close, ignore it and do not double the dose.
One of the side effects that can occur after consuming anagrelide is dizziness. To reduce the risk of these side effects, you should not rush to get up after taking the drug if you were previously in a sitting or lying position.
Do regular health checks to your doctor when using this medicine. Your doctor may ask you to undergo an electrocardiogram (EKG), blood tests, liver function tests, kidney function tests, and blood pressure or electrolyte levels in the blood.
Routine checks need to be carried out so that the development of the condition and the effectiveness of the drug can always be monitored.
Store anagrelide in a closed container in a cool and dry place away from direct sunlight. Keep this medicine out of reach of children.
Anagrelide Interactions with Other Drugs
There are several drug interactions that can occur if anagrelide is used with certain drugs, including:
- Enhanced effect of PDE III inhibitors ( phosphodiesterase III inhibitors ) , such as amrinone or cilostazol
- Increased risk of bleeding when used with clopidogrel , warfarin, enoxaparin , or aspirin
- Increased risk of cardiac QT prolongation when used with amiodarone or pimozide
- Increased risk of torsades de pointes type of heart rhythm disorder , if used with goserelin , histrelin, leuprolide, or triptorelin
Anagrelide Side Effects and Dangers
Side effects that can arise after consuming anagrelide are:
- Dizziness or headache
- Nausea or flatulence
- Lost appetite
- Body feels weak
- Tingling , numbness, or burning sensation
Call your doctor if the side effects above don't improve or get worse. Immediately see a doctor if you experience an allergic drug reaction or serious side effects, such as:
- Easy bruising , bleeding gums, or nosebleeds
- Bloody stools or bloody urine
- Vomiting blood , vomiting black, coughing up blood
- Swollen foot
- Severe stomach pain
- Unnatural tiredness or pallor
- Chest pain, palpitations , or fast heart rate
- Seizures , visual disturbances, weakness or paralysis on one side of the body