Anakinra is a drug to relieve the symptoms of rheumatoid arthritis . It is also used in the treatment of neonatal onset multisystem inflammatory disease (NOMID) or interleukin-1 receptor antagonist deficiency .

Anakinra belongs to the class of interleukin-1 receptor antagonists. This drug works by inhibiting the activity of interleukin-1 alpha and beta (IL-1). IL-1 is responsible for triggering an immune system response and inflammation in the body. By inhibiting the work of IL-1, the inflammation and complaints that occur will also subside.

Anakinra trademark : -

What is Anakinra

group Prescription drugs
Category Interleukin-1 . receptor antagonist
Benefit Relieves symptoms of rheumatoid arthritis and treats NOMID ( neonatal-onset multisystem inflammatory disease )
Used by Adults and children



Anakinra for pregnant and lactating mothers

Category B: Animal studies have shown no risk to the fetus, but there have been no controlled studies in pregnant women.

It is not yet known whether anakinra can be absorbed into breast milk or not. If you are breastfeeding, do not use this medication before consulting your doctor.

Drug form Inject

Warning Before Using Anakinra

Anakinra is a drug that can only be used according to a doctor's prescription. Here are some things to note using anakinra:

  • Tell your doctor about any allergies you have especially. Anakinra should not be used by someone who is allergic to this drug.
  • Tell your doctor if you have frequent infections , fever, kidney disease , asthma, tuberculosis , or a weakened immune system, including due to HIV/AIDS .
  • Tell your doctor if you are taking certain medications, supplements or herbal products.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor that you are using anakinra if you are planning to have any surgical procedures, including dental surgery.
  • Avoid direct contact with someone who has an infectious disease that is easily transmitted, such as the flu or measles , because this drug can increase your risk of infection.
  • Consult your doctor if during treatment with Ankinra you plan to get vaccinated.
  • See your doctor immediately if you experience a drug allergic reaction , serious side effects, or overdose after using this drug.

Dosage and Rules for Use Anakinra

The dose of anakinra given by the doctor can be different for each patient, depending on the condition to be treated and the patient's response to the drug.

Anakinra will be injected under the skin (subcutaneously/SC). In general, the dose of anakinra based on the condition you want to treat is as follows:

Condition: Rheumatoid arthritis

  • Adults: 100 mg once daily.

Anakinra can be used as a single drug or in combination with disease modifying antirheumatic drugs or DMARDs that are not tumor necrosis factor alpha inhibitors.

Condition: Neonatal onset multisystem inflammatory disease (NOMID) otherwise known as infantile neurologic cutaneous articular syndrome (CINCA)

  • Adults and children: Initial dose 1–2 mg/kg, once daily. The dose can be increased by 0.5–1 mg/kg to control active inflammation. The maximum dose is 8 mg/kg body weight.

Condition: Deficiency of interleukin-1 receptor antagonist (DIRA)

  • Adult: Initially 1–2 mg/kg, once a day. Dosage may be increased by 0.5–1 mg/kg to control active inflammation. The maximum dose is 8 mg/kg.

How to Use Anakinra Properly

Anakinra will be injected by a doctor or by medical personnel under the supervision of a doctor. While undergoing treatment with anakinra, follow the doctor's recommendations so that the treatment is more effective.

When using anakinra, you need to undergo regular health checks to make sure there are no side effects. The doctor may also ask you to have regular blood tests to monitor the effectiveness of therapy.

Anakinra Interactions with Other Drugs

Interaction effects that can occur when anakinra is used with certain drugs include:

  • Increased risk of serious infection when used with adalimumab , bariticinib , etanercept , fingolimod , or infliximab
  • Decreased effectiveness of live vaccines, such as BCG vaccine or measles vaccine

Side Effects and Dangers of Anakinra

Side effects that can occur after using anakinra are:

  • Headache
  • Diarrhea
  • Joint pain
  • Nausea or vomiting
  • Pain, redness and irritation at the injection site

Tell your doctor if these side effects do not improve or get worse. Tell your doctor right away if you have an allergic reaction to the drug, which can be characterized by symptoms, such as an itchy rash, difficulty breathing, or swelling of the eyelids or face.

In addition, the use of anakinra can increase the risk of developing a serious infection and can be fatal. Tell your doctor right away if you have any signs of infection, such as:

  • Fever , chills, or bone pain
  • Cough with phlegm
  • Sore throat that doesn't get better
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