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Arginine or L-arginine is an amino acid that can be used in the treatment of chest pain (angina ), high blood pressure, preeclampsia , erectile dysfunction, peripheral arterial disease , inflammation of the digestive tract in newborns, and recovery after surgery.

Naturally, arginine can be obtained by regularly consuming foods that contain protein, such as red meat, chicken, fish, dairy products, soy, whole wheat, or nuts.

In the body, arginine will be converted into nitric oxide. Nitric oxide acts to widen blood vessels, so blood can flow more smoothly. In addition, arginine also plays a role in stimulating the release of growth hormone, insulin, and other compounds in the body.

Arginine trademarks: Aminofusin Liver, Aminosteril Infant 10%, B-Fluid, Cefepime Hydrochloride, Comafusin Liver, Macef, Nuprosan, Renosan, Smofkabiven

What Is Arginine

group Prescription drug
Category Amino acid supplements
Benefit Used in the treatment of angina , high blood pressure, erectile dysfunction, or peripheral artery disease
Used by Adults and children
Arginine for pregnant and lactating women Category B:  Animal studies have not demonstrated a risk to the fetus, but there are no controlled studies in pregnant women.

Arginine can be absorbed into breast milk. For nursing mothers, consult a doctor before using this drug.

Drug form Inject

Warning Before Using Arginine

Follow the doctor's recommendations and suggestions while undergoing treatment with arginine. Before using this drug, you need to pay attention to the following points:

  • Do not use arginine if you are allergic to this drug. Tell your doctor about any history of allergies you have.
  • Tell your doctor if you have or are currently suffering from kidney disease, low blood pressure (hypertension ) , asthma, cirrhosis , recent heart attack, herpes , electrolyte imbalance, or recent surgery.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • Tell your doctor if you are taking certain medications, supplements or herbal products.
  • Immediately see a doctor if you experience an allergic drug reaction or overdose after using arginine.

Dosage and Rules for Using Arginine

Arginine will be given by injection through a vein (intravenously/IV) by a doctor or medical officer under the supervision of a doctor. The following are common dosages for arginine based on the patient's age:

  • Adults and children weighing 60 kg:  30 grams as a single dose, given by infusion over 30 minutes.
  • Children weighing <60 kg: 0.5 g/kgBW, given by infusion over 30 minutes.

How to Use Arginine Properly

Arginine will be given directly by a doctor or medical officer under the supervision of a doctor. The drug will be injected into a vein (intravenously/IV).

During treatment with arginine, the doctor will measure blood pressure regularly to ensure the condition and response to therapy. Follow your doctor's advice before and during treatment with arginine.

Interactions of Arginine with Other Drugs

The following are drug interaction effects that can occur if arginine is used together with other drugs:

  • Increased risk of developing hypoglycemia when used with anti-diabetes drugs, such as glimepiride
  • Increased risk of bleeding if used with anticoagulant drugs, such as warfarin
  • Increased risk of developing hypotension when used with antihypertensive drugs, nitrates , isoproterenol or sildenafil
  • Increased risk of developing hyperkalemia when used with potassium-sparing diuretic drugs, such as spironolactone or amiloride

Arginine Side Effects and Dangers

If used according to the instructions for use and the recommended dosage, arginine supplements are generally safe and rarely cause side effects. However, in some conditions, side effects can appear in the form of:

  • Burning, swelling, numbness or soreness at the injection site
  • Bloating  or stomach pain
  • Headache or dizziness
  • Nausea or vomiting

Check with your doctor if you experience any of the side effects mentioned above. See your doctor right away if you experience an allergic reaction to any medication after using arginine.

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