Atorvastatin is a drug to lower bad cholesterol (LDL) and triglycerides, and increase levels of good cholesterol (HDL) in the blood. If cholesterol in the blood is maintained at normal levels, the risk of stroke and heart attack will be lower.
Atorvastatin lowers the amount of cholesterol in the body by inhibiting the enzyme responsible for producing cholesterol in the liver. Thus, the amount of bad cholesterol in the blood will decrease.
Treatment with atorvastatin must be accompanied by a healthy lifestyle, such as exercising regularly, adjusting your diet, maintaining an ideal body weight, and quitting smoking . This is important to get the best treatment results.
Atorvastatin trademarks: Atorvastatin Calcium Trihydrate, Carduo, Cholestor, Genlipid 20, Lipidef, Stavinor 10
What is Atorvastatin
|Category||Statin cholesterol-lowering drugs|
|Benefit||Lowering cholesterol, reducing the risk of heart disease or stroke|
|Consumed by||Adults and children over 10 years|
|Atorvastatin for pregnant and lactating women||
Category X: Studies in experimental animals and humans have demonstrated fetal abnormalities or a risk to the fetus.
Drugs in this category should not be used in women who are or may become pregnant.
It is not known whether atorvastatin is absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.
|Drug form||Film-coated tablets|
Precautions Before Taking Atorvastatin
Pay attention to the following things before taking atorvastatin:
- Do not take atorvastatin if you are allergic to this drug.
- Tell your doctor if you have a history of liver disease, kidney disease, thyroid disorders, diabetes , or muscle disorders.
- Do not consume alcoholic beverages while undergoing treatment with atorvastatin because it can increase triglyceride levels and the risk of damage to the liver.
- Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
- Tell your doctor if you are taking other medications, including supplements and herbal products, to avoid unwanted drug interactions.
- See your doctor immediately if you have an allergic reaction or overdose, after taking atorvastatin.
Dosage and Rules for Use Atorvastatin
The following are common doses for atorvastatin:
Purpose: Management of familial homozygous hypercholesterolaemia (high cholesterol inherited from both parents)
- Adult: 10–80 mg daily, used as an adjunct to other lipid-lowering medications.
Conditions: Treatment of heterozygous familial hypercholesterolaemia (high cholesterol inherited from one parent) , nonfamilial hypercholesterolaemia (high cholesterol not due to heredity), and dyslipidemia
- Adult : Initially 10–20 mg once daily. In patients with very high cholesterol levels, the initial dose can be started at 40 mg once daily. Dosage may be adjusted according to body response to treatment within 2–4 weeks. The maximum dose is 80 mg per day.
- Children over 10 years: Initial dose 10 mg, once daily. The dose may be increased after 4 weeks, depending on the body's response to treatment. The maximum dose is 20 mg per
Condition: Prevention of cardiovascular disease in high-risk patients
- Adult A : 10 mg per day. Dosage can be increased according to the patient's condition.
How to Take Atorvastatin Correctly
Follow the doctor 's recommendations and read the information listed on the drug packaging label before taking atorvastatin.
Swallow the atorvastatin tablet whole with the help of a glass of water. Atorvastatin can be taken after or before meals. Do not crush or split the tablet as this may increase the risk of side effects.
If you are also taking other medications to lower cholesterol, such as cholestyramine or colestipol, take atorvastatin 1 hour before or 4 hours after.
Try to take atorvastatin at the same time each day. If you forget to take atorvastatin, take it as soon as you remember if the break with the next consumption schedule is not too close. If it's close, ignore it and don't double the dose.
Finish the given dose. Do not stop taking atorvastatin without your doctor's approval, even if you feel better. This aims to prevent the possibility of symptoms reappearing.
Store atorvastatin at room temperature, in a dry place, away from sunlight. Keep atorvastatin out of reach of children.
Atorvastatin Interactions with Other Drugs
Interactions that can occur if atorvastatin is used together with certain drugs include:
- Increased risk of developing muscle disorders (myopathies) and rhabdomyolysis when used with ciclosporin , fusidic acid , ritonavir, itraconazole, ketoconazole , clarithromycin, erythromycin , verapamil, diltiazem , fenofibrate, gemfibrozil , ezetimibe, niacin , and colchicine
- Decreased levels of atorvastatin in the body when used with rifampicin , efavirenz, phenytoin , antacids, or colestipol
- Increased risk of side effects from digoxin drugs and oral contraceptives, such as norethisterone and ethinyl estradiol
In addition, grapefruit or its products can increase blood levels of atorvastatin, increasing the risk of side effects. Limit consumption of this fruit while you are taking atorvastatin.
Side Effects and Dangers of Atorvastatin
The following are possible side effects after taking atorvastatin:
- Joint and muscle pain
- Stuffy nose, sore throat
Check with your doctor if these side effects don't go away or get worse. See a doctor immediately if you experience an allergic reaction to the drug or any of the following serious side effects:
- Liver disorders, which are characterized by pain in the upper abdomen, weakness, fatigue, loss of appetite, dark urine, and yellowish eyes and skin ( jaundice )
- Symptoms of rhabdomyolysis , such as muscle pain or muscle weakness
- Kidney disorder, which is characterized by urinating less, swelling in the ankles, and shortness of breath
- Unusual fever and tiredness