Baricitinib is a drug used to treat moderate to severe rheumatoid arthritis . This drug can be given as a single drug or in combination with other drugs.
Rheumatoid arthritis occurs when the body's immune system attacks joint tissue and cartilage, causing inflammation in the joints. Baricitinib works by suppressing the work of the immune system which previously attacked healthy joint tissue and cartilage. That way, the symptoms of inflammation can subside.
Baricitinib trademark: Olumiant
What is Baricitinib
|Benefit||Treat rheumatoid arthritis of moderate to severe severity|
|Consumed by||Adults and elderly aged ≥75 years|
|Baricitinib for pregnant and lactating women||
Category D: There is positive evidence of a risk to the human fetus, but the benefits may outweigh the risks, for example in dealing with life-threatening situations.
Baricitinib can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.
Warnings Before Taking Baricitinib
Baricitinib should only be used as prescribed by a doctor. There are several things that must be considered before using this drug, including:
- Tell your doctor about any history of allergies you have. Baricitinib should not be used by patients who are allergic to this drug.
- Tell your doctor if you have or have ever had kidney disease, liver disease, diverticulitis , stomach ulcer, duodenal ulcer , cancer, blood disorder , lung disease, or any infectious disease, hepatitis C , hepatitis B, tuberculosis , herpes, HIV/AIDS .
- Consult your doctor if you plan to be vaccinated with live vaccines, such as the BCG vaccine, while on treatment with baricitinib.
- As much as possible, avoid close contact with people with infectious diseases that are easily transmitted, such as the flu or measles, while taking baricitinib, as this can increase your risk of contracting it.
- Tell your doctor that you are taking baricitinib if you plan to have dental work or surgery.
- Tell your doctor if you are taking certain medications, supplements or herbal products.
- Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
- Tell your doctor right away if you have an allergic reaction to any medication, serious side effects, or an overdose after taking baricitinib.
Dosage and Rules for Use of Baricitinib
The following is a breakdown of the dose of baricitinib to relieve rheumatoid arthritis symptoms based on the patient's age:
- Adults : 4 mg once daily for patients with moderate to severe rheumatoid arthritis. The dose may be reduced to 2 mg once daily when the patient's condition improves.
- Elderly 75 years: The dose is 2 mg once daily.
How to Take Baricitinib Properly
Follow the doctor 's recommendations and read the instructions for use listed on the package before using baricitinib. Do not increase or decrease the dose, and do not use the drug for longer than the time recommended by the doctor.
Take baricitinib at the same time every day for maximum benefits. Baricitinib tablets can be taken before or after meals.
If you forget to take baricitinib, it is advisable to consume it immediately if the break with the next schedule is not too close. If it's close, ignore it and don't double the dose.
The use of baricitinib can weaken the immune system and make the patient more susceptible to infection. Therefore, follow the doctor's advice to always undergo regular checkups that have been scheduled.
Store baricitinib in a closed place at a cool temperature. Protect this drug from direct sunlight. Keep this drug out of reach of children.
Baricitinib Interactions with Other Drugs
The use of baricitinib with other drugs can cause interactions between drugs, including:
- Decreased effectiveness of live vaccines, such as the BCG vaccine
- Increased risk of tearing in the digestive tract which can cause digestive tract bleeding when used with non-steroidal anti-inflammatory drugs ( NSAIDs ), such as ibuprofen
- Increased risk of serious side effects from disease modifying anti-rheumatic drugs (DMARD) biologics, such as adalimumab and infliximab
- Increased risk of fatal infectious diseases when used with corticosteroid drugs , such as methylpredisolone
- Enhanced immune suppressive effect when used with strong immunosuppressants, such as azathioprine, methotrexate , ciclosporin, or tacrolimus
- Increased levels of baricitinib when used with probenecid
Baricitinib Side Effects and Dangers
Some of the side effects that can occur after using baricitinib are as follows:
- Impaired liver function, which can be characterized by certain symptoms, such as jaundice , dark urine, loss of appetite, nausea and vomiting that doesn't stop
- Sores in the digestive tract, which can be characterized by severe and persistent nausea and vomiting or severe abdominal pain
- Anemia , which can be characterized by the appearance of certain symptoms, such as fatigue, weakness, lethargy, or skin that looks pale
- Chest pain , difficulty breathing, cold hands or feet, or swelling and redness in the legs.
Check with your doctor if you experience any of the symptoms listed above or have an allergic drug reaction .
In addition, the use of baricitib can increase the risk of developing serious infectious diseases, including fungal infections, bacterial infections , or viral infections. Immediately see a doctor if you experience signs and symptoms of infection while using baricitinib, such as:
- Sores on the skin that do not heal
- Persistent cough