Bile Acid Sequestrant

Bile Acid Sequestrant

Bile acid sequestrants or bile acid binders are a group of drugs used to lower bad cholesterol or low-density lipoprotein (LDL) levels. In Indonesia, this drug is available in the form of a suspension powder.

Bile acid sequestrant works by binding to bile acids in the intestine and excreting them with the feces. Bile acid itself is a liquid produced in the liver using cholesterol from the blood. This liquid is then released into the intestine to help process food processing.

Normally, bile acids in the intestines can be absorbed into the bloodstream and carried to the liver for reuse. Due to reduced bile acids that can be absorbed in the intestine, the liver will convert more cholesterol into bile acids. That way, cholesterol levels in the blood can also be reduced.

Bile acid sequestrant is rarely used as a single drug to lower cholesterol. This is because this class of drugs can only reduce bad cholesterol levels by 10-25%. Therefore, bile acid sequestrants are usually combined with other cholesterol-lowering drugs, such as statins or niacin.

Warning Before Using Bile Acid Sequestrant

Follow the doctor's recommendations and suggestions while undergoing treatment with bile acid sequestrant or bile acid binders. Before using this drug, you need to pay attention to the following points:

  • Tell your doctor about any history of allergies you have. Bile acid sequestrant should not be used by patients who are allergic to this drug.
  • Tell your doctor if you have or have had a blood clotting disorder, constipation , difficulty swallowing, hemorrhoids, liver disease, high triglyceride levels, vitamin A, D, E, or K deficiency, thyroid disorder, or kidney disease.
  • Tell your doctor if you have had surgery on your stomach or intestines.
  • Tell your doctor if you have phenylketonuria , as some bile acid sequestrant products may contain phenylalanine.
  • This medicine should not be used in patients under 18 years of age.
  • Carry out the control according to the schedule given by the doctor. You may need to have regular blood tests while taking a bile acid sequestrant.
  • Tell your doctor if you are taking certain medications, supplements, or herbal products.
  • Tell your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.
  • See a doctor immediately if you have an allergic drug reaction, serious side effects, or an overdose after using bile acid sequestrant.

Side Effects and Dangers of Bile Acid Sequestrant

Side effects of bile acid sequestrants or bile acid binders vary, depending on the type of medication. However, in general, there are some side effects that can occur after using bile acid sequestrant drugs, namely:

  • Bloated
  • No appetite
  • Nauseous
  • Constipation
  • Diarrhea
  • Irritation of the tongue, skin, and the area around the anus

Check with your doctor if the above side effects appear. You should also see a doctor immediately if you have  an allergic reaction to the drug or a more serious side effect occurs, such as:

  • Severe constipation
  • Severe stomach pain
  • Bloody pee
  • Black stools like asphalt or bloody stools
  • Unusual bruising or bleeding

Types and Trademarks of Bile Acid Sequestrant

The following are the types of drugs that are included in the bile acid sequestrant class, along with their trademarks and dosages:

  1. Cholestyramine
    Drug form: Powder
    Trademark: Sequest
    To find out the dosage and further information about this drug, please open the cholestyramine drug page .
  1. Colestipol
    Drug forms: Powder and tablets
    Trademark: -
    To find out the dosage and further information about this drug, please open the colestipol drug page .
  1. Colesevelam Medicinal
    form: Powder and tablet
    Trademark: -
    For dosages and further information regarding this drug, please visit the Colesevelam drug page .
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