Calcitriol is the active form of vitamin D which is used to treat and prevent calcium deficiency and bone disease. This drug is generally prescribed to patients with chronic kidney disease or disorders of the glands that produce calcium levels (parathyroid hormone).
Calcitriol works by helping the body absorb more calcium and regulates the production of parathyroid hormone. For better results, the use of calcitriol is usually accompanied by a special diet and sometimes in combination with other supplements or drugs.
Calcitriol trademarks: Calcitriol, Calesco, Kolkatriol, Oscal, Ostovel, Ostriol, Triocol
What is Calcitriol
Precautions Before Taking Calcitriol
Before consuming calcitriol, you need to pay attention to the following things:
- Do not take calcitriol if you have an allergy to this drug.
- Tell your doctor if you have or are currently suffering from hypercalcemia (high calcium levels in the blood), coronary heart disease , heart rhythm disorders, malabsorption syndrome , liver disease, or kidney disease , including kidney stones .
- Tell your doctor if you have recently had surgery or are on bed rest for a long time, as these conditions can increase your risk of side effects.
- Be sure to avoid dehydration by meeting your daily fluid requirements while using calcitriol.
- Tell your doctor if you are taking any other medications, including herbal products or supplements, to anticipate drug interactions.
- Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
- See your doctor immediately if you have an allergic reaction or overdose after taking calcitriol.
Dosage and Rules for Use of Calcitriol
The calcitriol dosage prescribed by a doctor can be different for each patient. The following is the dosage of calcitriol based on the patient's condition and age:
Condition: Hypocalcemia or bone disorders in patients with chronic renal failure
- Adult: 0.25 mcg, once daily or once every 2 days.
- Children: 0.25–2 mcg, 1 time daily.
- Adult: 0.25 mcg, once a day. Maintenance dose 0.5–2 mcg, once daily.
- Children <1 year: 0.04–0.08 mcg/kg, once daily.
- Children 1–5 years: 0.25–0.75 mcg, once daily.
- Children >6 years of age: 0.5–2 mcg, once daily.
Condition: Hyperparathyroidism secondary to impaired renal function
- Adult: 0.25–0.5 mcg, once daily.
- Children aged <3 years : 0.01–0.015 mcg/kg once daily.
- Children ≥3 years : 0.25–0.5 mcg once daily.
Condition: Osteoporosis related to menopause
- Adults: 0.25 mcg 2 times daily
How to Take Calcitriol Correctly
Follow the doctor 's recommendations and read the information listed on the drug packaging label before taking calcitriol. Do not reduce or increase your dose without consulting your doctor first.
Calcitriol can be taken after or before meals. Consume calcitriol regularly at the same time every day for maximum effect.
If you are taking mineral oil, orlistat, or bile acid binders , such as cholestyramine or colestipol, leave a gap of 2 hours between taking these drugs and calcitriol.
Keep taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor.
If you forget to take calcitriol, it is advisable to do it immediately if the break with the next consumption schedule is not too close. If it is close, ignore it and do not double the dose.
Calcitriol requires calcium to work effectively. However, excess calcium can cause dangerous hypercalcemia . Therefore, calcitriol users need to undergo a special diet so that the body receives sufficient daily calcium intake and does not overdo it.
Calcitriol users are advised to get at least 600 mg of calcium per day from food. While patients who are undergoing dialysis or dialysis need to undergo a low phosphate diet. Therefore, follow the advice of your doctor or nutritionist to ensure that you receive sufficient daily calcium intake.
Store calcitriol at room temperature and in a closed container to avoid exposure to sunlight, and keep out of reach of children.
Calcitriol Interactions with Other Drugs
The following are interactions that can occur when using calcitriol with other drugs:
- Increased risk of developing hypercalcemia when used with thiazide diuretics, such as hydrochlorothiazide
- Increased risk of hypermagnesemia in patients on dialysis if used with magnesium-containing drugs, such as antacids
- Decreased absorption of calcitriol when used with cholestyramine or sevelamer
- Decreased effectiveness of carcitriol when used with carbamazepine , phenobarbital, phenytoin , or corticosteroids
- Increased risk of arrhythmias when used with digitalis drugs, such as digoxin
- Increased risk of overdose or hypervitaminosis when used with other products containing vitamin D
Calcitriol Side Effects and Dangers
Calcitriol rarely causes side effects. However, the following side effects may occur after taking calcitriol:
- Dry mouth
- Abdominal pain
- Nausea and vomiting
- Constipation or constipation
- Loss of appetite
- Muscle ache
- Weight loss
Check with your doctor if the above complaints appear. In addition, go to the emergency room immediately if you experience a drug allergic reaction or symptoms of hypercalcemia, such as feeling unusually tired, confused, bone pain, irregular heartbeat, or frequent urination.