Calcium Antagonists

Calcium Antagonists

Calcium-channel blockers (CCBs) or calcium antagonists are a group of drugs that are useful for lowering blood pressure. This medicine should only be used as prescribed by a doctor. In addition to lowering blood pressure, calcium antagonists are also used to treat disorders of the heart and blood vessels.

Calcium antagonist drugs work by blocking calcium from entering the heart cells and blood vessel walls. This way of working will make it easier for the heart to pump blood and dilate blood vessels. As a result, there will be a decrease in blood pressure.

There are several conditions and diseases that can be treated with the use of calcium antagonists, including:

  • Hypertension
  • Angina pectoris, Prinzmetal's angina, and stable angina
  • Arrhythmia

In addition, several types of calcium-channel blockers can also be used to prevent and treat heart attacks and conditions of lack of oxygen or blood flow to the brain when experiencing subarachnoid hemorrhage .

Precautions Before Using Calcium Antagonists

Calcium antagonists should not be used carelessly. Follow the doctor 's recommendations while undergoing treatment with this drug. Before taking calcium antagonists, you need to pay attention to the following things:

  • Do not use calcium antagonist drugs if you are allergic to these drugs.
  • Do not consume grapefruit while taking calcium antagonist medications. Consumption of grapefruit along with the use of calcium antagonists can affect blood pressure and heart rate.
  • Do not drink alcoholic beverages while using this medication. Alcohol can increase the effectiveness of the drug and the risk of side effects.
  • Tell your doctor if you are taking other blood pressure-lowering drugs or are taking herbal medicines, vitamins or other supplements.
  • Tell your doctor if you have and have ever had heart disease , kidney problems, liver  problems, breathing problems, blood vessel disorders, stroke , hypertension, diabetes, intestinal obstruction  , inflammation and infection of the gums, brain edema , and increased intracranial pressure .
  • Tell your doctor if you are pregnant, nursing, or planning a pregnancy
  • Discuss with the pediatrician regarding the use of calcium antagonist drugs in children, so that the type of drug and dosage given is correct.
  • If  you have an allergic reaction  or overdose after taking a calcium antagonist, contact your doctor immediately.

Side Effects and Dangers of Calcium Antagonists

There are several side effects that have the potential to arise from the use of calcium antagonist drugs, including:

  • Headache or dizziness
  • Mouth feels dry
  • Low blood pressure
  • Your heart feels like it's beating faster, slower, or irregularly ( arrhythmia )
  • Nausea, constipation , or diarrhea
  • Acid reflux disease ( GERD )
  • Muscles feel weak or cramped
  • Swelling of the legs and feet ( edema )
  • Easy to fall asleep

Consult a doctor if you experience the above symptoms. See a doctor immediately , if your symptoms get worse or if you have an allergic drug reaction, such as an itchy rash, swelling of your eyelids and lips, or shortness of breath.

Types, Trademarks, and Dosages of Calcium Antagonists

There are different types and brands of calcium antagonists. The dose of calcium antagonist given depends on the type and form of the drug, as well as the patient's age and condition. Here are the details:


Trademarks: Amlodipine Besilate, Amlodipine Besylate, Amovask, Comdipin, Concor AM, Normetec, Norvask, Quentin, Simvask, and Zenovask

To find out the dosage and further information about this drug, please open the amlodipine drug page .


Trademarks: Cordila SR, Dilmen, Diltiazem, Farmabes and Herbesser

To find out the dosage and more information about this drug, please visit the diltiazem drug page .


Trademark: -

  • Conditions: hypertension
    Adult: initial dose 5 mg per day. The dose can be adjusted according to the patient's response to the drug. The usual dose is 2.5–10 mg per day.
  • Condition: angina pectoris
    Adult: initial dose 5 mg daily. The dose can be increased to 10 mg per day.


Trademark: -

  • Condition: hypertension
    Adults: initial dose 2.5 mg, 2 times daily. If needed, after 3–4 weeks, the dose may be increased to 5 mg, 2 times daily or 10 mg, 2 times


Trademarks: Blistra, Carsive, Dipitenz, Nicardipine Hydrochloride, Nicardipine HCL, Nicardex, Perdipine, Quadipine, Tensilo, and Verdif

To find out the dosage and more information about this drug, please visit the nicardipine drug page


Trademarks: Ceremax, Nimodipine G, and Nimotop

To find out the dosage and further information about this drug, please open the nimodipine drug page .



Condition: angina pectoris or hypertension

  • Adults: initial dose of 5 mg or 10 mg fast-release tablets, 2 times a day for a week. The maximum dose is 20 mg, 2 times a day.
  • Controlled release tablet dosage is 17 mg once daily. Maintenance dose 8.5 mg once daily. The maximum dose is 34 mg per day.


Trademarks: Isoptin, Isoptin SR, Tarka and Verapamil HCL

To find out the dosage and more information about this drug, please visit the verapamil drug page .

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