Canakinumab is used to treat cryopyrin-associated periodic syndrome (CAPS),  tumor necrosis factor receptor-associated periodic syndrome (TRAPS) , hyperimmunoglobulin D syndrome (HIDS) or mevalonate kinase deficiency (MKD) , and familial mediterranean fever (FMF).

Canakinumab works by inhibiting the interleukin-1 beta protein in the body, so it can relieve symptoms of inflammation, such as rashes, muscle aches, fever, red eyes, and fatigue. Canakinumab is also used to treat  systemic juvenile idiopathic arthritis (SJIA) or  Still's disease .

Trademarks of canakinumab: -

What is Canakinumab

Group Interleukin-1 beta . blockers
Category Prescription drug
Benefit Treat periodic fever syndrome
Consumed by Adults and children aged 2 years and over
Canakinumab for pregnant and lactating women Category N:  Not yet categorized.

It is not known whether Canakinumab is absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug form Inject

Precautions Before Using Canakinumab

The following are some things you need to pay attention to before using canakinumab:

  • Tell your doctor about any history of allergies you have. Canakinumab should not be used by patients who are allergic to this drug.
  • Tell your doctor if you have or currently have tuberculosis , leukopenia, chronic infections, HIV/AIDS , hepatitis B, hepatitis C , or cancer.
  • Tell your doctor if you are experiencing an infectious disease that can be marked by certain symptoms, such as fever, chills, fatigue, cough, shortness of breath, diarrhea, or sudden drastic weight loss.
  • Consult your doctor if you plan to get vaccinated while using canakinumab. This medicine may reduce the effectiveness of vaccines, especially vaccines that use live bacteria.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • Do not drive a vehicle or operate heavy machinery while being treated with canakinumab, because this drug can cause dizziness.
  • See your doctor right away if you have an overdose, drug allergic reaction, or a more serious side effect after using canakinumab.

Dosage and Instructions for Use Canakinumab

Canakinumab will be given by injection under the skin (subcutaneous / SC) by a doctor or medical officer under the supervision of a doctor. The following is the distribution of canakinumab doses based on the conditions you want to treat:

Condition: Cryopyrin -associated periodic syndrome (CAPS)

  • Adults and children weighing >40 kg: 150 mg every 8 weeks.
  • Adults and children weighing ≤15 kg–40 mg: 2 mg/kg every 8 weeks.

Conditions: Tumor necrosis factor receptor associated periodic fever syndrome (TRAPS), hyperimmunoglobulin D (HIDS) syndrome or mevalonate kinase (MKD) deficiency

  • Adult weighing 40 kg: 2 mg/kg every 4 weeks.
  • Adults weighing >40 kg: 150 mg every 4 wk.
  • Children weighing 7.5–≤40 kg: 2 mg/kg every 4 weeks.
  • Children with body weight >40 kg: 150 mg every 4 weeks.

Condition: Familial mediterranean fever (FMF)

  • Adults weighing ≤40 kg: 2 mg/kg every 4 weeks. Treatment will be combined with colchicine .
  • Adults weighing >40 kg: 150 mg every 4 wk. Treatment will be combined with colchicine.
  • Children weighing 7.5–≤40 kg: 2 mg/kg every 4 weeks. Treatment will be combined with colchicine.
  • Children weighing >40 kg: 150 mg every 4 weeks. Treatment will be combined with colchicine.

Condition: Adult-onset still's disease (AOSD) or systemic juvenile idiopathic arthritis (SJIA)

  • Adult: 4 mg/kg every 4 wk, as single treatment or in combination with methotrexate. The maximum dose is 300 mg.

How to Use Canakinumab Correctly

Canakinumab will be given directly by  a doctor or medical officer under the supervision of a doctor. Follow the advice and recommendations of your doctor while you are undergoing therapy using canakinumab.

Make sure to carry out routine controls according to the schedule given by the doctor. While undergoing treatment with canakinumab, you need to have regular complete blood tests.

Canakinumab Interactions with Other Drugs

Using canakinumab with other medicines can cause the following interactions:

  • Decreased effectiveness of live vaccines, such as the BCG vaccine
  • Increased risk of serious infection when used with tumor necrosis factor inhibitors, such as certolizumab or adalimumab

Canakinumab Side Effects and Dangers

Side effects that may arise after using canakinumab are:

  • Itching, redness, swelling, or warmth at the injection site
  • Dizziness or headache
  • Nausea or vomiting
  • Diarrhea
  • Weight gain

Check with your doctor if the side effects above don't go away. Immediately consult a doctor if a drug allergic reaction appears, which can be marked by the appearance of an itchy rash on the skin, swollen eyes and lips, or difficulty breathing.

In addition, the use of canakinumab can also increase the risk of developing infectious diseases, such as pneumonia ( pneumonia ), inflammation of the sinuses (sinusitis), or bone and joint infections. Immediately see a doctor if signs of infection appear, such as:

  • Fever, chills, chills, lasting more than 3 days
  • Diarrhea accompanied by abdominal pain
  • Cough or shortness of breath
  • Pain and burning sensation when urinating
  • Wounds that don't heal
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