Captopril is a drug to  treat hypertension or heart failure. This drug may also be used in the treatment of post-heart attack or kidney disease due to diabetes (diabetic nephropathy).

Captopril or captopril is an ACE inhibitor class of drugs  that works by inhibiting the conversion of angiotensin I to angiotensin II. Angiotensin plays a role in constricting blood vessels. This way of working will help dilate blood vessels, so that blood flow is smoother and blood pressure decreases.

This drug can also reduce complications due to hypertension and also has a protective effect on the kidneys. This drug can be used alone or in combination with other drugs.

Captopril trademarks :  Acendril, Acepress, Captopril, Dexacap, Etapril, Farmoten, Otoryl, Prix 25, Scantensin, Tensobon, Tensicap, Tensicap 12.5, Vapril 25

What is Captopril

group Prescription drug
Category ACE inhibitors 
Benefit Overcoming hypertension and heart failure, preventing complications after a heart attack, and treating diabetic nephropathy
Consumed by Adults, children and seniors
Captopril for pregnant and lactating women Category D: There is positive evidence of risk to the human fetus, but the benefits may outweigh the risks, for example in dealing with a life-threatening situation.

Captopril can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug form Tablet

Precautions Before Taking Captopril

Captopril should only be consumed according to a doctor's prescription. Before taking this drug, there are several things you need to pay attention to, including:

  • Tell your doctor about any history of allergies you have. Captopril should not be used in patients who are allergic to this drug or other ACE inhibitor class drugs , such as perindopril .
  • Tell your doctor if you have renal artery stenosis, anuria or angioedema Captopril should not be given to patients with these conditions.
  • Tell your doctor if you have lupus , kidney disease, diabetes , liver disease, hyperkalemia , are on dialysis ( hemodialysis ), connective tissue disease, such as Marfan syndrome or scleroderma .
  • Do not drive a vehicle or operate equipment that requires alertness while taking captopril, because this drug can cause
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy. Captopril should not be used by pregnant women
  • Tell your doctor if you are taking certain supplements, herbal products, or medications. Captoril should not be used with aliskiren or sacubitril.
  • Tell your doctor that you are taking captopril if you are planning to have surgery or any other medical procedure, including dental surgery.
  • See a doctor immediately if you experience a drug allergic reaction , serious side effects, or overdose after taking captopril.

Dosage and Rules for Using Captopril

The doctor will determine the dose of captopril according to your age, the condition you want to treat, and the severity of the condition. In general, the following are the captopril dosages:

Condition: Hypertension

  • Adult: Initially 25–75 mg 2–3 times daily. Dosage may be increased to 100–150 mg, divided into 2–3 doses after 2 weeks of use.
  • Children aged less than 1 year: 0.15 mg/kg per day.
  • Children and adolescents : 0.3 mg/kg per day.
  • Elderly: Initially 6.25 mg daily.

Condition: Heart failure

  • Adult: Initial dose 6.25–12.5 ml, 2–3 times daily. Maintenance dose 75–150 mg daily.
  • Children aged less than 1 year: 0.15 mg/kg per day.
  • Children and adolescents : 0.3 mg/kg per day.
  • Elderly: Initially 6.25 mg daily.

Condition: Post-heart attack

  • Adult: Initial dose less than 24 hours after symptom onset is 6.25 mg, followed by 12.5 mg after 2 hours and 25 mg after 12 hours.
  • Adult: The initial dose after more than 24 hours of symptom onset is 6.25 mg 3–16 days after cardiac arrest. Dosage may be increased to 12.5–25 mg, 3 times daily for 2 days. Maintenance dose 75–150 mg 2–3 times daily.
  • Children aged less than 1 year: 0.15 mg/kg per day.
  • Children and adolescents : 0.3 mg/kg per day.
  • Elderly: Initially 6.25 mg daily.

Condition: Diabetic nephropathy

  • Adults: 75–100 mg daily.
  • Children aged less than 1 year: 0.15 mg/kg per day.
  • Children and adolescents : 0.3 mg/kg per day.
  • Elderly: Initially 6.25 mg daily.

How to Take Captopril Correctly

Use captopril as directed by your  doctor and don't forget to read the information on the drug packaging. Do not increase or decrease the dose, and do not use the drug for more than the recommended time.

Captopril should be taken on an empty stomach, ideally 1 hour before or 2 hours after a meal. This drug is usually recommended to be taken before going to bed because it can cause dizziness in the early stages of use.

Make sure there is sufficient time between one dose and the next. Try to take captopril at the same time every day to maximize the drug's effectiveness.

If you forget to take captopril, it is recommended to consume it immediately if the break with the next consumption schedule is not too close. If it's close, ignore it and don't double the dose.

Do not stop taking captopril without consulting your doctor first, even if you feel that your condition is getting better. To control blood pressure, you are advised to adopt a low-salt and low-fat diet, exercise regularly, don't smoke, and limit alcoholic beverages.

Check blood pressure and health to the doctor regularly while taking captopril to monitor the development of the body's condition.

Store captopril at room temperature, and avoid heat, humidity and direct sunlight. Keep medicine out of reach of children.

Captopril Interactions with Other Drugs

There are several interactions between drugs that can occur if captopril is taken with certain drugs, including:

  • Increased risk of hypotension, hyperkalemia and impaired renal function when used with aliskiren
  • Increased risk of angioedema when used with sacubitril, temsirolimus, or everolimus
  • Increased risk of anaphylactic shock when used with dextran sulfate
  • Increased levels of lithium in the blood which can cause drug poisoning
  • Increased risk of having too low a blood sugar level (hypoglycemia) when using glibenclamide or glimepiride
  • Increased risk of developing leukopenia (low levels of white blood cells) when used with procainamide or immunosuppressant drugs
  • Increased risk of side effects, such as low blood pressure, when used with tricyclic antidepressants (TCAs), antipsychotics, or diuretics
  • Decreased effectiveness of captopril and increased risk of kidney disorders when used with NSAID class drugs

Captopril Side Effects and Dangers

Some of the common side effects that occur when taking captopril are:

  • Dizziness or a sensation of floating
  • Losing the ability to feel
  • Warm feeling in the face, neck, or chest ( flushing )
  • Dry cough
  • Low blood pressure
  • Chest pain
  • Rapid heartbeat or pounding heart

Check with your doctor if the side effects above don't go away. Immediately go to the doctor if you have an allergic reaction to the drug or experience more serious side effects, such as:

  • Very severe fainting or dizziness
  • Very fast heart rate
  • High levels of potassium in the blood (hyperkalemia), which can be characterized by symptoms such as a slow or irregular heartbeat and muscle weakness
  • Impaired kidney function , which can be characterized by symptoms such as infrequent urination or the amount of urine that comes out very little
  • Impaired liver function , which may be characterized by symptoms such as severe stomach pain, severe nausea and vomiting, or jaundice
  • Infectious disease , which can be characterized by symptoms such as fever, chills, or sore throat
  • Angioedema, which can be characterized by symptoms such as swelling of the face, tongue, or lips
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