Carbimazole is  a drug used to overcome the symptoms of hyperthyroidism or excess thyroid hormone. This medicine can only be bought with a doctor's prescription and used as recommended by the doctor.

Carbimazole works by reducing the production of thyroid hormone by an overactive thyroid gland. That way, the symptoms of hyperthyroidism , such as rapid heart rate, excessive sweating, drastic weight loss, and unstable mood, can improve.

In addition to overcoming hyperthyroidism, carbimazole is also used in the preparation stage before radioactive iodine therapy and thyroidectomy (surgery to remove the thyroid gland), both total and partial.

Carbimazole brand name: Neo-Mercazole

What Is Carbimazole?

Group Prescription drugs
Category Antithyroid
Benefits Treating hyperthyroidism, preparation before thyroidectomy, preparation before radioactive iodine therapy
Consumed by Adults and children
Carbimazole for pregnant and lactating women Category D: There is evidence that the content of the drug poses a risk to the fetus, but the benefit obtained may be greater than the risk, for example to overcome a life-threatening situation.

Carbimazole can be absorbed into breast milk. If you are breastfeeding, do not consume this medicine without consulting a doctor.

Drug form Tablets

Warnings Before Consuming Carbimazole

There are some things you need to know before undergoing treatment with carbimazole:

  • Do not consume carbimazole if you are allergic to this drug. Tell your doctor about any allergies you have.
  • Do not consume carbimazole if you have previously experienced side effects such as acute pancreatitis as a result of consuming carbimazole or thiamazole.
  • Tell your doctor if you are pregnant, breastfeeding, or planning to become pregnant.
  • Tell your doctor if you have had or are currently suffering from liver disease, blood disorders, bone marrow disorders,  goiter , or lactose intolerance .
  • Consult a doctor if you are using other drugs, including supplements and herbal products.
  • Tell your doctor that you are taking carbimazole if you are scheduled to undergo certain laboratory tests, such as liver function tests or bleeding time.
  • Tell your doctor immediately if you experience fever or stomach pain while taking carbimazole. This condition can be a symptom of acute pancreatitis and the use of carbimazole may have to be discontinued.
  • See a doctor immediately if you experience a drug allergic reaction, serious side effects, or overdose after consuming carbimazole.

Dosage and Administration of Carbimazole

Here is the dose of carbimazole based on the patient's age:

  • Adults: Initial dose 15–60 mg per day, divided into 2–3 times the consumption schedule. The dose will be reduced gradually after the function of the thyroid gland returns to normal. The maintenance dose is 5–15 mg daily.
  • Children aged  3–17 years: Initial dose of 15 mg daily, adjusted to the patient's body response to the drug.

How to Consume Carbimazole Correctly

Follow the doctor's advice and read the information on the medicine packaging. Do not increase or decrease the dose without consulting a doctor. Usually improvement of symptoms will be seen after 3 weeks of consuming carbimazole.

Consume carbimazole regularly at the same time every day. Carbimazole can be consumed before or after a meal with a glass of water. Swallow the medicine whole, do not chew or crush it.

If you forget to take carbimazole, take it as soon as you remember. If it is time to take the next dose, combine the missed dose with the previous dose (2 doses at once). If you are in doubt or confused, consult a doctor first.

During treatment with carbimazole, you are advised to perform thyroid hormone tests routinely to find out the body's response to the drug. Follow the control schedule given by the doctor.

Be aware that supplements containing biotin can reduce the accuracy of thyroid hormone testing. To ensure your test results are accurate during monitoring, do not take biotin supplements while you are taking carbimazole.

Store carbimazole in a dry, covered place, away from direct sunlight. Keep the medicine out of the reach of children.

Interactions of Carbimazole with Other Drugs

The following are the interaction effects that can occur if carbimazole is consumed with certain drugs:

  • Increased risk of bleeding if taken together with anticoagulant drugs , such as warfarin or heparin
  • Increased risk of theophylline and erythromycin side effects
  • Decreased effectiveness of prednisolone

In carbimazole users who have reached normal thyroid hormone levels, interaction effects that can occur include:

  • Increased levels of digoxin and the risk of side effects from digoxin
  • Decreased effectiveness of beta blockers , such as propranolol or atenolol

If the hyperthyroid patient also consumes the above drugs, the dose of the drug needs to be changed and adjusted to the patient's needs after a few moments of consuming carbimazole.

In addition, consuming herbal medicine containing black cohosh can affect the effectiveness of carbimazole.

Side Effects and Dangers of Carbimazole

Side effects usually appear in the first 2 months after starting treatment. The following are side effects that may arise after consuming carbimazole:

  • Nausea
  • Vomiting
  • Diarrhea
  • Headache or dizziness
  • Joint pain
  • Change of taste
  • Itching and skin rash
  • Hair loss

The side effects above will usually subside on their own after your body gets used to carbimazole. However, do a doctor's examination if the symptoms feel bothersome or do not subside.

See a doctor immediately if you experience a drug allergic reaction or more serious side effects, such as:

  • A decrease in white blood cells and infection, which can be marked by fever, sore throat, thrush, toothache, flu symptoms, or swollen lymph nodes
  • Acute pancreatitis, which can be characterized by severe abdominal pain that occurs suddenly
  • Liver disease, which can be marked by a change in the color of the skin and eyes to yellow ( jaundice ) and dark colored urine
  • Easy bruising or bleeding
  • Hypoglycemia , which is characterized by fatigue, shaking, cold sweats, or fainting
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