Cefazolin

Cefazolin

Cefazolin is an antibiotic drug used to treat bacterial infections, such as urinary tract infections or pheumonia . This medicine can also be used to prevent bacterial infections in someone who is about to have or has had surgery.

Cefazolin belongs to the class of cephalosporin antibiotics. This drug works by inhibiting the formation of bacterial cell walls and stopping the replication or proliferation of bacteria. Please note, this drug cannot be used to treat infections due to viruses, such as the flu .

Cefazolin trademarks:  Cefazol, Cefazolin Sodium

What is Cefazolin

class Prescription drug
Category Cephalosporin antibiotics
Benefit Treating bacterial infections and preventing bacterial infections before and after surgery
Used by Adults and children over 1 year old
Cefazolin for pregnant and lactating women Category B:  Animal studies have not demonstrated a risk to the fetus, but there are no controlled studies in pregnant women.

Cefazolin can be absorbed into breast milk. Tell your doctor if you are breastfeeding.

Drug form Inject

Warning Before Using Cefazolin

Before using this medicine, you need to pay attention to the following things:

  • Tell your doctor about any allergies you have. Cefazolin should not be used by patients who are allergic to this drug or to other cephalosporin drugs, such as cefadroxil .
  • Tell your doctor if you have or have had kidney disease, liver disease, seizures , diarrhea, or colitis .
  • Tell your doctor if you plan to get vaccinated with live vaccines, such as typhoid vaccine, while having treatment with cefazolin, because these drugs may reduce the effectiveness of the vaccines.
  • Tell your doctor if you are taking certain medications, supplements, or herbal products.
  • Tell your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.
  • See your doctor right away if you have an allergic drug reaction, serious side effect, or overdose after using cefazolin.

Dosage and Instructions for Use of Cefazolin

Cefazolin will be injected through a muscle (intramuscular/IM) or a vein (intravenous/IV) by a doctor or medical officer under the supervision of a doctor. The following are common doses of cefazolin:

Condition: Bacterial infection

  • Adults: 0.25–1.5 grams, every 6–8 hours. The maximum dose is 12 grams per day.
  • Children over 1 year of age: 25–50 mg/kgBW per day, divided into 3–4 doses. The maximum dose is 100 mg/kg body weight per day.

Condition: Uncomplicated acute urinary tract infection

  • Adult: 1 gram, every 12 hours. The maximum dose is 12 grams per day.
  • Children over 1 year of age: 25–50 mg/kgBW per day, divided into 3–4 doses. The maximum dose is 100 mg/kg body weight per day.

Condition: Pneumonia

  • Adult: 500 mg, every 12 hours. The maximum dose is 12 g per day.
  • Children over 1 year of age: 25–50 mg/kgBW per day, divided into 3–4 doses. The maximum dose is 100 mg/kg body weight per day.

Condition: Prevention of infection during and before surgery

  • Adults: 1 g, administered 30–60 minutes before surgery. For long-term procedures followed by 0.5–1 gram, during surgery. Thereafter, 0.5–1 gram, every 6–8 hours, after surgery, for 1–5 days.

How to use Cefazolin correctly

Cefazolin will be given directly by a doctor or medical officer under the supervision of a doctor. The drug will be injected through a vein (intravenous/IV) or into a muscle (intramuscular/IM), as directed by the doctor.

Follow the injection schedule given by the doctor for effective treatment. While on treatment, you may need to have regular medical tests to check your body's response to the drug.

Cefazolin Interactions with Other Drugs

The following are some of the effects of drug interactions that can occur if cefazolin is used with certain drugs:

  • Enhanced anticoagulant effect of warfarin
  • Decreased effectiveness of sodium picosulfate , BCG vaccine, or typhoid vaccine
  • Increased risk of impaired kidney function if used with aminoglycoside class drugs
  • Decreased effectiveness of  phenytoin or fosphenytoin
  • Increased blood levels of cefazolin when used with probenecid

Cefazolin Side Effects and Dangers

The following are side effects that can arise after using cefazolin:

  • Headache
  • Nausea or vomiting
  • Diarrhea
  • Loss of appetite
  • Swelling, redness, or pain at the injection site

Check with your doctor if the side effects mentioned above do not subside or get worse. See your doctor right away if you have   an allergic reaction to a drug or a more serious side effect, such as:

  • Swelling in the feet or legs
  • Mood swings, confusion, or seizures
  • Fast , irregular, or pounding heartbeats
  • Severe diarrhea, accompanied by blood, or severe abdominal pain
  • Fever , joint pain, or feeling unwell
  • Liver disease that can be characterized by symptoms such as yellow skin, upper abdominal pain, dark urine, or loss of appetite

In addition, the use of cefazolin in the long term and repeated can increase the risk of fungal infections, including in the mouth. Check with your doctor if you have canker sores or white patches appear on your mouth and tongue.

Back to blog