Cefoperazone-sulbactam is an antibiotic used to treat various diseases caused by bacterial infections, such as respiratory tract infections, infections of the organs in the stomach, meningitis, septicemia, urinary tract infections, or bone and joint infections.

Cefoperazone is a third generation cephalosporin antibiotic that inhibits the formation of bacterial cell walls, while sulbactam works by inhibiting the action of the beta lactamase enzyme, a bacterial growth enzyme that can reduce the effect of cefoperazone. With the combination of these two drugs, their effectiveness in treating bacterial infections will increase.

Trademarks of cefoperazone-sulbactam:  Baxcef, Cefoperazone/Sulbactam, Cefoperazone Sodium/Sulbactam Sodium, Cefratam, Ferotam, Fosular, Nubac, Simextam, Sulbacef, Zotam

What is Cefoperazone-Sulbactam

class Prescription drug
Category  Cephalosporin antibiotics
Benefit Treats bacterial infections
Used by Adults and children
Cefoperazone-sulbactam for pregnant and lactating women Category N:  Unknown. Cefoperazone-sulbactam is known to be absorbed into breast milk in small amounts. Breastfeeding women are advised to consult with their doctor before using this drug.
Drug form Inject

Precautions Before Using Cefoperazone-Sulbactam

Before using cefoperazone-sulbactam, you need to pay attention to the following points:

  • Tell your doctor about any allergies you have. Cefoperazone-subactam should not be used by someone who is allergic to this drug, penicillins , or cephalosporin antibiotics, such as ceftazidime .
  • Tell your doctor if you have had or currently have liver disease , biliary obstruction , kidney disease , or malabsorption syndrome .
  • Tell your doctor if you are taking certain medications, supplements or herbal products.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
  • See your doctor right away if you have an allergic reaction or overdose after using cefoperazone-sulbactam.

Dosage and Instructions for Use Cefoperazone-Sulbactam

The dose of cefoperazone-sulbactam can be different for each patient. This depends on the age and condition of each. However, in general the following is the dose of cefoperazone-sulbactam according to the patient's age:


  • Mild-moderate bacterial infections are 1–2 grams per day, with a 1:1 ratio of cefoperazone and sulbactam levels.
  • For more serious infections, the maximum dose is 4 grams per day, divided into 2 doses, with an interval of 12 hours per administration.


  • The dose given by the doctor is 0.02–0.04 gram/kgBW per day, with a 1:1 ratio of cefoperazone and sulbactam levels. The dose is divided into 2-4 times, with a distance of 6-12 hours per administration.
  • To treat serious bacterial infections, the maximum dose is 0.08 grams/kg body weight per day.

How to Use Cefoperazone-Sulbactam Properly

Cefoperazone-sulbactam will be given by injection into a vein (intravenous/IV) or into a muscle (intramuscular/IM) by a doctor or medical officer under the supervision of a doctor. Follow the injection schedule given by the doctor for effective treatment.

While using this drug, you may need to have regular kidney and liver function tests. Follow the examination schedule that has been set by the doctor so that the treatment is optimal.

Cefoperazone-Sulbactam Interactions with Other Drugs

Using cefoperazone -sulbactam with anticoagulant drugs , such as warfarin , will increase the risk of bleeding. In addition, when used with alcoholic beverages it can cause side effects in the form of a burning sensation in the chest, neck or face (flushing), sweating, headache and tachycardia .

To prevent drug interactions, always consult your doctor if you plan to use cefoperazone-sulbactam with any medications, supplements, or herbal products.

Cefoperazone-Sulbactam Side Effects and Dangers

Some of the side effects that can occur after using cefoperazone-sulbactam are:

  • Pain at the injection site
  • Diarrhea
  • Headache
  • Fever or chills
  • Nausea or vomiting
  • Thrombocytopenia , which is a low number of platelets (platelets)
  • Eosinophilia, which is a high number of one type of white blood cell ( eosinophil )

Check with your doctor if the side effects mentioned above don't go away or get worse. You should also see a doctor immediately if you experience a drug allergic reaction after using cefoperazone-sulbactam.

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