Cefpirome is an antibiotic that is useful for overcoming diseases caused by bacterial infections in various parts of the body, such as  the lower respiratory tract, urinary tract, skin and soft tissue, and blood .

Cefpirome is a 4th generation cephalosporin antibiotic that can kill bacteria by inhibiting bacterial cell wall synthesis. Cefpirome is available in 1 gram injection powder vials.

 Cefpirome trademarks :  Bactirom, Bioprom, Caprocef, Cefir, Cefpirome Sulfate, Cefmer, Cefnos, Cefpirome, Cefrin, Erpharom, Givincef, Interome, Lanpirome, Lapirom, Morcef, Nufirom, Pirofion, Pirom, Quaceprom, Rime, Romicef

What is Cefpirome?

Group Prescription drugs
Category Cephalosporin antibiotics
Benefits Treat upper and lower urinary tract  infections, skin and soft tissue infections, lower respiratory tract infections  , infections in patients with neutropenia, bacteremia, or septicemia
Used by Adults
Cefpirome for pregnant and lactating women Category B:  Studies on experimental animals do not show any risk to the fetus, but there are no controlled studies in pregnant women.

Cefpirome can be absorbed into breast milk. If you are breastfeeding, consult your doctor before using this medicine.

Drug form Injection powder.

Warnings Before Using Cefpirome

Cefpirome is a prescription drug. Consider the following before undergoing treatment with cefpirome:

  • Do not use cefpirome if you have an allergy to this medicine.
  • Do not use this medicine if you suffer from porphyria .
  • Tell your doctor if you are allergic to other cephalosporin antibiotics or penicillin antibiotics .
  • Tell your doctor if you have a history of kidney disorders  and blood disorders .
  • Tell your doctor if you plan to or are using other medicines, including supplements and herbal products.
  • Tell your doctor if you are pregnant, breastfeeding, or planning to become pregnant.
  • See a doctor immediately if you experience a drug allergic reaction or overdose.

Dosage and  Administration of Cefpirome

Here is the general dose of cefpirome for adults based on the condition:

Condition: Complicated upper and lower urinary tract infection (UTI).

  • 1 gr is given by intravenous injection (intravenous/IV) every 12 hours. The dose can be increased to 2 gr depending on the severity.

Conditions: Skin  and soft tissue infection

  • 1 gr is given by IV injection every 12 hours. The dose can be increased to 2 gr depending on the severity.

Condition:  Lower respiratory tract infection

  • 1–2 gr given by IV injection every 12 hours

Conditions: Infection in patients with neutropenia, bacteremia , or septicemia

  • 2 gr given by IV injection every 12 hours.

How  to Use Cefpirome Correctly

Cefpirome injection can only be given by a doctor or medical personnel under the supervision of a doctor.
Be sure to undergo treatment with cefpirome according to the doctor's instructions, even if the condition has improved. Stopping the drug before the prescribed time can increase the risk of a more severe infection.
In addition, immediately consult a doctor if the condition experienced does not improve or worsens.

Interactions of Cefpirome  with Other Drugs

Interaction effects that can occur if used together with certain drugs are:

  • Increased risk of side effects from cefpirome if used with probenecid
  • Increased risk of kidney damage if used with aminoglycoside antibiotics  or   loop diuretics

Side Effects and Dangers of  Cefpirome 

Side effects that can appear due to the use of cefpirome include:

  • Swelling or irritation in the injected skin area
  • Disturbance of smell or taste temporarily after getting an injection
  • Headache
  • Nausea and vomiting
  • Fever
  • Diarrhea
  • Candidiasis

Contact a doctor if the side effects do not improve immediately or worsen. See a doctor immediately if you experience a drug allergic reaction  or more serious side effects, such as:

  • Colitis , which can be marked by abdominal pain, diarrhea, or watery or bloody stools
  • Thrombocytopenia , which can be marked by pale skin, easy bruising, or bleeding
  • Liver function disorders or h.emolytic anemia , which can be marked by dark colored urine or jaundice (yellowing of the skin and eyes)
  • Acute kidney failure , which can be characterized by a decrease in the amount of urine and frequency of urination, swelling in the legs, or pain in the abdomen and back
  • Agranulocytosis , which can be marked by symptoms of infection, such as fever, cough, runny nose, chills, sore throat, or bone pain
  • Encephalopathy , which can be marked by difficulty speaking or swallowing, body twitching, muscle weakness, or decreased consciousness
  • Convulsions
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