Ceftriaxone is a drug to treat  diseases caused by bacterial infections , such as gonorrhea, meningitis , otitis media, syphilis, and Lyme disease. This drug is available in injectable form.

Cefriaxone is a cephalosporin class of antibiotics. This drug works by killing and inhibiting the growth of infection-causing bacteria in the body. In addition, ceftriaxone can also be used to prevent infection during surgery.

Please note, ceftriaxone cannot be used to treat infections caused by viruses, such as the flu .

Cefriaxone trademarks : Betrix, Broadced, Ceftriaxone Sodium, Cefaxon, Ceftrimet, Cetriax, Erphacef, Foricef, Futaxon, Gracef, Intrix, Racef, Renxon, Triasco, Trijec, Tricefin, Trixon, Tyason, and Zeftrix.

What is  Ceftriaxone

class Prescription drugs
Category Cephalosporin antibiotics 
Benefit Treat and prevent bacterial infections
Used by Adults and children
Ceftriaxone for pregnant and lactating women Category B: Animal studies have not demonstrated a risk to the fetus, but there are no controlled studies in pregnant women.

Cefriaxone can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug form Inject

Precautions Before Using Cefriaxone

Ceftriaxone should only be used according to a doctor's prescription. This medicine should not be used in premature babies, babies less than 1 month old, or  babies with jaundice . Other things that need to be considered before using this drug, namely:

  • Tell your doctor if you are allergic to ceftriaxone or any other cephalosporin class of antibiotics.
  • Tell your doctor if you have liver disease, kidney disease, diabetes, bleeding disorders, gallbladder disease, anemia, diarrhea,  pancreatitis , malnutrition, or digestive disorders, such as ulcerative colitis .
  • Tell your doctor if you are getting vaccinated with a live bacterial vaccine, such as the typhoid vaccine, BCG vaccine, or cholera vaccine. Ceftriaxone may decrease the effectiveness of this vaccine.
  • Tell your doctor that you are taking ceftriaxone before having any surgery or medical procedure, including dental surgery.
  • Tell your doctor if you are taking any other medications, including supplements and herbal products, to anticipate drug interactions.
  • Tell your doctor if you are pregnant, planning a pregnancy, or are breastfeeding.
  • Immediately consult a doctor if you experience a drug allergic reaction , serious side effects, or an overdose after using ceftriaxone.

Dosage and Instructions for Use of Ceftriaxone

Cefriaxone is given as an injection. Ceftriaxone can be given by IM injection (intramuscular/through muscle), IV injection (intravenous/through a vein), or IV infusion by a doctor or medical staff under the supervision of a doctor.

The dose of ceftriaxone is different for each patient. The doctor will determine the dose and duration of treatment according to the patient's condition. In children, the dose of ceftriaxone will be determined by the doctor based on the patient's body weight (BB).

The following is the distribution of ceftriaxone doses based on the condition being treated:

Condition: Bacterial infection that can be treated with ceftriaxone

  • Adults: 1,000–2,000 mg per day. In severe infections, the dose may be increased to 4,000 mg 1–2 times daily. Treatment is given by IM injection, IV injection over 5 minutes, or IV infusion over 30 minutes.
  • Children aged < 15 days : 20–50 mg/kg, once a day given by IV infusion for 60 minutes.
  • Children 15 days to 12 years: 50–80 mg/kg per day. The maximum dose is 4,000 mg per day.

Condition: Uncomplicated gonorrhea

  • Adult: 250–500 mg as a single dose by IM injection.

Condition: Acute otitis media

  • Adults and children >12 years of age weighing 50 kg: 000–2,000 mg single dose by IM injection.
  • Children aged ≤12 years weighing <50 kg: 50 mg/kg as a single dose by IM injection.

Condition: Syphilis

  • Adult: 500–1000 mg or 2000 mg for syphilis affecting the brain, once daily, for 10–14 days. Treatment can be given by IM injection, IV injection over 5 minutes, or infusion over 30 minutes.
  • Children < 15 days: 50 mg/kg per day by IV injection over 60 minutes.
  • Children 15 days to 12 years: 75–100 mg/kg per day by IV injection, for 10–14 days. The maximum dose is 4,000 mg/kg body weight per day.

Condition: Lyme disease

  • Adult: 000 mg, once daily for 14–21 days. Treatment can be given by IM injection, IV injection over 5 minutes, or infusion over 30 minutes.
  • Children 15 days to 12 years old weighing <50 kg: 50–80 mg/kg, once daily for 14–21 days. Treatment can be given by infusion for at least 30 minutes.

Condition:  Meningitis

  • Adult:  2,000 mg 12 hourly by IV injection for 7–14 days.
  • Children:  100 mg/kg per day, in 1 or 2 doses, by IV or IM injection, for 7–14 days.

Condition: Prevention of surgical wound infection

  • Adult: 1000–2000 mg, given by IV injection ½ –2 hours before surgery.
  • Children < 15 days old: 20–50 mg/kg by IV infusion over 60 minutes.
  • Children aged 15 days to 12 years weighing <50 kg : 50–80 mg/kg by IV infusion over 30 minutes.

How to use Ceftriaxone correctly

Ceftriaxone is only available in injectable form. Therefore, this drug should only be given by a doctor or medical officer under the supervision of a doctor. The doctor will determine the method and schedule for administering ceftriaxone according to the patient's condition.

While undergoing treatment with ceftriaxone, it is recommended to drink lots of water so that your kidney health is maintained. If you are taking ceftriaxone on an outpatient basis, follow the control schedule determined by the doctor.

Ceftriaxone Interactions with Other Drugs

Interaction effects that can occur if ceftriaxone is used with other drugs are:

  • Increased risk of crystallization in the lungs and kidneys which can be fatal if used with fluids containing calcium, such as calcium gluconate
  • Increased risk of bruising or bleeding if used with warfarin
  • Increased risk of kidney damage when used with aminoglycoside antibiotics

Ceftriaxone Side Effects and Dangers

Some of the side effects that can occur after using ceftriaxone are:

  • Swelling, redness, or pain at the injection site
  • Headache
  • Dizzy
  • Nausea or vomiting
  • Diarrhea
  • vaginal itching or discharge
  • skin rash
  • Drowsiness
  • Stomach ache
  • Excessive sweating

Consult a doctor if the complaints mentioned above do not subside or get worse. Call your doctor right away if you have an allergic reaction to a drug, or a more severe side effect, such as:

  • Irregular heartbeat ( arrhythmia )
  • Appearance of signs of infection, such as fever, chills, or sweats
  • bloody diarrhea
  • Shortness of breath or wheezing
  • Dark or pink urine
  • Pain when urinating
  • Back pain
  • Jaundice
  • Confusion
  • Uncontrolled body movements
  • Bruising or bleeding
  • Fatigue or weakness
  • seizures
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