Cisplatin is a chemotherapy drug used to treat certain types of cancer, such as ovarian cancer , testicular cancer, or bladder cancer . This drug can be used alone or in combination with other anticancer drugs.

Cisplatin is a chemotherapy drug that contains platinum. This drug works by inhibiting the formation of cell DNA so that it can slow down and stop the growth of cancer cells .

Cisplatin trademarks: Cilatin 50, Cisteen, Cisplasan, Cisplatin, Platol

What is Cisplatin

class Prescription drug
Category Chemotherapy drugs
Benefit Treat ovarian cancer, testicular cancer, and bladder cancer
Used by Adults and children
Cisplatin for Pregnant and Breastfeeding Mothers Category D: There is positive evidence of risk to the human fetus, but the benefits may outweigh the risks, for example in dealing with a life-threatening situation.

Cisplatin can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor.

Medicine Form Inject via IV

Warning Before Using Cisplatin

The following are some things you need to pay attention to before using cisplatin:

  • Tell your doctor about any history of allergies you have. Cisplatin should not be used by patients who are allergic to this drug.
  • Tell your doctor if you have or have ever had kidney disease , hearing loss, gout , pins and needles, anemia , low white blood cell count (leukopenia), thrombocytopenia , or electrolyte imbalance, such as salt deficiency, hypokalemia , or hypomagnesemia .
  • Tell your doctor if you are having radiotherapy or are taking any other medicines, including supplements or herbal products.
  • Tell your doctor that you are taking cisplatin before undergoing certain medical procedures or surgery.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy. Use effective contraception during treatment with cisplatin for up to 11–14 months afterward.
  • As much as possible, avoid close contact with people with infectious diseases that are easily transmitted, such as the flu, because it can increase your risk of contracting it.
  • Tell your doctor if you plan to get vaccinated while on treatment with cisplatin.
  • See your doctor right away if you have an allergic drug reaction, serious side effect, or overdose, after using cisplatin.

Dosage and Rules for Use Cisplatin

The dose of cisplatin given will be adjusted to the conditions being treated and the patient's age. The following details the general dose of cisplatin given by intravenous (intravenous/IV) infusion for adult patients:

Condition: Ovarian cancer that has spread (metastasized)

  • The dose is 75–100 mg/m2 body surface area (LPT) per cycle, every 4 weeks. This drug will be combined with cyclophosphamide .

Condition: Testicular cancer that has spread

  • The dose is 20 mg/m2 LPT for 5 days per cycle. The dose will be repeated every 3 weeks. The drug will be combined with bleomycin and etoposide.

Condition: Advanced bladder cancer

  • The dose is 50–70 mg/m2 LPT per cycle, every 3–4 weeks, the dose will be adjusted according to the radiotherapy or chemotherapy that has been undertaken.

How to Use Cisplatin Properly

Cisplatin will be given by a doctor or medical officer under the supervision of a doctor. This drug will be given into a vein, for 6-8 hours. Always follow the doctor's recommendations while undergoing treatment with this drug.

Consume lots of water while using cisplatin to prevent kidney damage due to cisplatin use. Tell your doctor right away if cisplatin leaks and gets on your skin. Cisplatin can injure the skin affected by the drug.

During treatment with cisplatin, your doctor will ask you to have regular blood tests to check your kidney function, liver function, and blood cell counts.

Your doctor may also order other tests, such as hearing tests, to monitor your condition and your response to medications. Do not stop medication without consulting your doctor first.

Cisplatin Interactions with Other Drugs

Drug interaction effects that can occur if cisplatin is used with certain drugs include:

  • Decreased therapeutic effect of cisplatin when used with pyridoxine
  • Decreased effectiveness of the trivalent influenza vaccine or quadrivalent influenza vaccine
  • Increased risk of infection when used with tofacitinib
  • Increased blood levels of cisplatin when used with tafenoquine or trilaciclib
  • Increased risk of cisplatin poisoning when used with palifermin
  • Increased risk of developing kidney or ear damage if used with amphotericin B , cidofovir, or bacitracin

Cisplatin Side Effects and Dangers

There are several side effects that can arise after using cisplatin, namely:

  • Nausea or vomiting
  • Lost appetite
  • Diarrhea
  • Loss of the ability of the sense of taste to taste the food or drink consumed
  • Hair loss

Tell your doctor if the above side effects do not improve or get worse. See a doctor immediately if you have an allergic drug reaction or serious side effects, such as:

  • Easy bruising , nosebleeds that are more frequent and difficult to stop, or bleeding gums
  • Pain, redness, or swelling at the injection site
  • Pain behind the eye, blurry vision, or blindness
  • Headaches, seizures , or mental and mood disturbances,
  • Chest pain or swelling, pain, and redness in the legs
  • Hearing loss , which can be characterized by symptoms such as tinnitus , sudden deafness, or difficulty hearing high-pitched sounds
  • Impaired kidney function which can be characterized by symptoms such as swelling in the legs, very little amount of urine, or infrequent urination
  • An infectious disease caused by a low white blood cell count which can be characterized by symptoms such as sore throat , fever, cough, or canker sores
  • Impaired nervous system function which can be characterized by symptoms such as reduced reflexes, the appearance of burning, tingling , or numbness in the feet and hands
  • Decreased effect of cisplatin when used with sodium thiosulfate
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