Clomifene is a drug to treat infertility or infertility in women who have ovulation disorders. One of the causes of infertility in women is a disruption in the process of ovulation or the release of mature eggs from the ovaries into the fallopian tubes , making it difficult for pregnancy to occur.

Clomifene or clomiphene is a selective estrogen receptor modulator (SERM) drug . This drug will trigger an increase in the production and amount of hormones that are responsible for stimulating the ovaries to produce eggs. This drug will also stimulate the maturation and release of egg cells (ovulation) which can also be used as a drug to speed up menstruation .

Clomifene trademarks: Bifertil, Blesifen, Clomifene Citrate, Clomifil, Clovertil, Dipthen, Fervula, Fertin, Fertion, Genoclom, GP-Fertil, Provula, Profertil, Pinfetil.

What is Clomiphene

class Prescription drugs
Category Synthetic hormone selective estrogen receptor modulator
Benefit Overcoming infertility or infertility due to disruption of ovulation
Consumed by Mature
Clomifene for pregnant and lactating women Category X: Studies in animals and humans have demonstrated an abnormality to the fetus or a risk to the fetus. This drug should not be used by women who are or may become pregnant.

It is not known whether clomiphene is absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug form Tablet

Precautions Before Taking Clomifene

Clomifene should only be taken as prescribed by a doctor. There are several things that must be considered before using this drug, including:

  • Tell your doctor about any allergies you have. Clomifene should not be taken by patients who are allergic to this drug.
  • Tell your doctor if you have or are experiencing unexplained vaginal bleeding, PCOS , liver disease, fibroids, endometriosis , adrenal gland disease, brain tumor , or high triglycerides .
  • Tell your doctor if you miss your period after taking clomifene, because clomifene must be stopped if you become pregnant.
  • Tell your doctor if you are taking certain medications, supplements, or herbal products.
  • Do not drive a vehicle and do activities that require alertness after taking clomiphene, as this medicine can cause dizziness .
  • Immediately consult a doctor if you experience a drug allergic reaction, serious side effects, or an overdose after taking clomifene.

Dosage and Rules for Use of Clomifene

Clomifene is given to treat infertility due to ovulation disorders. This drug will be given to women of childbearing age who are planning a pregnancy.

In general, the dose of clomifene for this condition is 50 mg, once a day. The drug can be started on the 5th day of the menstrual cycle, when there is no bleeding.

If ovulation does not occur, administration of the drug can be repeated at a dose of 100 mg, once a day, for 5 days, starting 30 days after the first dose. Repetition of doses can be done up to a maximum of 3 times.

How to Take Clomifene Correctly

Follow the doctor 's advice and read the information listed on the drug packaging label before consuming clomiphene. Do not increase or decrease the dose without consulting your doctor first.

Clomifene tablets can be taken with or without food. Swallow the tablet whole with a glass of water. Do not split, grind, crush or chew the medicine.

Take clomifene at the same time every day for maximum treatment. If you forget to take it, take this drug immediately if the break with the next usage schedule is not too close. If it is close, ignore it and do not double the dose.

Clomifene needs to be consumed on the 5th day of menstruation or according to doctor's instructions. Around 5–10 days after taking clomifene it is expected that ovulation will occur. In order to increase your chances of getting pregnant, your doctor will advise you and your partner to have sex during ovulation.

Store clomiphene in tightly closed containers in a cool room. Do not store in a humid place and protect this medicine from direct sunlight. Keep this medicine out of reach of children.

Clomifene Interactions with Other Drugs

Always tell your doctor if you are taking certain medications, supplements, or herbal products. The effects of drug interactions that can occur if clomiphene is used with other drugs are as follows:

  • Increased risk of inflammation of the pancreas (pancreatitis) when used with bexarotene
  • Increased risk of side effects, such as blood clot formation, stroke, when used with ospemifene

Clomifene Side Effects and Dangers

There are several side effects that can arise after taking clomifene, namely:

  • Warm feeling in the face, neck, or chest ( flushing )
  • Pain or discomfort in the breast
  • Vomiting or stomach pain
  • Vaginal spotting or bleeding outside the menstrual cycle.

Check with your doctor if the side effects mentioned above don't go away or get worse. Immediately see a doctor if a drug allergic reaction appears or serious side effects appear, such as:

  • Vision disturbances which can be in the form of blurred vision, eye pain, or the appearance of black dots or spots when seeing
  • Swollen belly, severe stomach pain, nausea and vomiting that doesn't go away, or diarrhea
  • Chest pain , swelling or pain in the legs, shortness of breath, fast or irregular heartbeat
  • Mental and mood disorders ( mood )
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