Colchicine is a drug to treat pain caused by gout attacks that occur suddenly. This drug can also be used to prevent recurrence of attacks of gout (uric acid disease) which is characterized by severe pain in joints, such as the thumb or knee joints, due to increased levels of uric acid.

Colchicine works by stopping the formation of a special protein, so it can prevent the activation and movement of neutrophil -type white blood cells to areas of inflammation. That way, complaints of swelling and joint pain due to gout attacks will subside.

Colchicine is only used to relieve pain due to gout, not to relieve pain due to other conditions or causes.

Colchicine trademarks: Ar-gout, Colchicine, Colcitine, Frigout, L-Cisin, Nucine, Pyricin, Recolfar

What is Colchicine

class Prescription drug
Category Uricosuric or anti-gout drugs
Benefit Prevent and relieve acute gout attacks
Consumed by Mature
Colchicine for pregnant and lactating women Category C: Animal studies have shown adverse effects on the fetus, but there have been no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Colchicine can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor.

Drug form Tablet

 Warnings Before Taking Colchicine:

Colchicine should only be taken according to a doctor's prescription. There are several things that must be considered before using this drug, including:

  • Do not take colchicine if you are allergic to this drug. Always tell your doctor about any allergies you have.
  • Tell your doctor if you have kidney failure or are on dialysis . Colchicine should not be used in patients with these conditions.
  • Tell your doctor if you have had or currently have kidney disease, heart and blood vessel disease, corneal ulcers , or liver disease .
  • Tell your doctor if you are taking any medications, supplements or herbal products.
  • Do not consume alcoholic beverages while undergoing treatment with colchicine because it can reduce the effectiveness of the drug.
  • If you plan to have dental work or surgery, tell your doctor that you are taking colchicine.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • Immediately consult a doctor if you have an allergic drug reaction, serious side effects, or an overdose after taking colchicine

Dosage and Rules for Use of Colchicine

The following are common doses of colchicine for adults based on their intended use:

Purpose: Relieves attacks of gout

Initial dose of 1 mg, followed by 0.5 mg 1 hour thereafter. Treatment can be carried out within 12 hours of the first complaint appearing. The maximum dose is 0.5 mg every 8 hours until symptoms disappear or after reaching the maximum dose of 6 mg. When you have reached the maximum dose, colchine can only be consumed 3 days later.

Goal: Prevent gout attacks

The dosage is 0.5 mg, 2 times a day.

How to Take Colchicine Properly

Follow the doctor 's recommendations and read the information listed on the drug packaging label before taking colchicine. Do not increase or decrease your dose without consulting your doctor first, because this can increase the risk of serious side effects.

Colchicine can be taken before or after meals. Take medicine with water.

Immediately consume colchicine when the first symptoms of a gout attack appear, so that the treatment results are more optimal. Do not delay taking colchicine, because the medication may be less effective.

If after 1 hour the joint pain is still felt, you may need to take colchicine again at a lower dose, as directed by your doctor.

Long-term use of colchicine needs to be accompanied by regular health checks, so that your doctor can monitor your health progress.

To maximize treatment, the use of colchicine should be accompanied by a reduction in consumption of high-purine foods, such as chicken liver or sardines.

Store colchicine in a closed container in a cool place away from direct sunlight. Keep out of reach of children.

Colchicine Interactions with Other Drugs

The use of colchicine together with other drugs can cause the following drug-to-drug interactions:

  • Impaired absorption of vitamin B12
  • Increased risk of muscle disorders ( myopathy ) and rhabdomyolysis if used with statins, fibrates, ciclosporin, or digoxin drugs
  • Increased levels of colchicine when used with cimetidine or tolbutamide
  • Increased risk of bone marrow damage causing a low white blood cell count ( leukopenia ) or a low platelet count ( thrombocytopenia ) when used with phenylbutazone
  • Increased risk of gastrointestinal bleeding when used with NSAIDs
  • Increased risk of drug poisoning if used with macrolide antibiotics, calcium antagonist drugs , ritonavir, itraconazole , ketoconazole, or disulfiram

In addition, if taken with grapefruit , colchicine levels in the blood can increase, even at levels that can cause drug poisoning.

Colchicine Side Effects

Some side effects that may occur after using colchicine are:

  • Nausea or vomiting
  • Diarrhea
  • Cramps or stomach ache

Check with your doctor if the side effects above don't go away or get worse. Immediately stop taking colchicine and see a doctor if an allergic reaction to the drug or more serious side effects occurs, such as:

  • Muscle ache
  • Tingling or numbness in the fingers or toes
  • Easy bruising
  • Easy fever, easy sore throat, and not feeling well
  • Heart beat
  • Pale lips, tongue and palms
  • Tired or limp
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