Dipyridamole is a medication to prevent blood clots from forming after heart valve replacement surgery. Blood clots that block blood vessels can cause strokes, pulmonary embolism, or heart attacks.

Dipyridamole belongs to the antiplatelet group. This drug works by preventing blood platelets or platelets from sticking together and forming blood clots. In addition, this drug also has an effect in dilating blood vessels (vasodilation).

This drug can also be used as an addition or adjuvant to thallium 201 to assist the process of radiological examination of the heart.

Dipyridamole trademarks: Aggrenox, Persantin, Vasocor

What is Dipyridamole

class Prescription drugs
Category Antiplatelet
Benefit Prevents the formation of blood clots and helps radiological examination of the heart
Used by Mature

Dipyridamole for pregnant and lactating women

Category B: Animal studies have not demonstrated a risk to the fetus, but there are no controlled studies in pregnant women.

Dipyridamole can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug form Film-coated tablets, slow-release caplets, and injections

Warning Before Using Dipyridamole

Dipyridamole should only be used as prescribed by a doctor. There are several things that must be considered before using this drug, including:

  • Tell your doctor about any allergies you have. Dipyridamole should not be given to patients who are allergic to this drug.
  • Tell your doctor if you have or currently have low blood pressure (hypotension), migraines , myasthenia gravis, angina , coronary heart disease, liver disease , or a blood clotting disorder, such as thrombocytopenia, hemophilia , or von Willebrand's disease
  • Tell your doctor if you recently had a heart attack .
  • Tell your doctor that you are taking dipyridamole if you are planning to have surgery, including dental surgery.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • Tell your doctor if you are taking any other medicines, including herbal medicines and supplements.
  • Do not drive a vehicle or do activities that require alertness while being treated with dipyridamole, because this drug can cause dizziness .
  • See your doctor right away if you have an allergic drug reaction, serious side effect, or overdose after using dipyridamole.

Dosage and Rules for Using Dipyridamole

The dose of dipyridamole is determined based on the age of the patient and the form of the drug. The following is the dosage of dipyridamole for adults based on the form of the drug:

Drug form: Tablet

Condition: Prevention of blood clots ( thromboembolism ) after heart valve replacement surgery

  • The dose is 300–600 mg per day divided into 3–4 consumption schedules, given with anticoagulant drugs

Medication form: Slow release caplet

Condition: Prevention of ischemic stroke or prevention of minor stroke or transient ischemic attack ( TIA )

  • The dose is 200 mg, 2 times a day.

In addition, dipyridamole can also be used to assist in cardiac radiology, which is imaging to see blood flow in the heart. This drug will be used as an adjuvant or adjuvant of thallium-201 at a dose of 0.142 mg/kgBW per minute, given by infusion for more than 4 minutes.

How to Use Dipyridamole Properly

Injectable dipyridamole will be given by a doctor or medical officer under the supervision of a doctor. Always follow your doctor's advice before, during and after treatment with dipyridamole.

Follow the doctor 's recommendations and read the instructions on the drug packaging before taking dipyridamole in tablet or caplet form. Do not increase or decrease your dose without consulting your doctor.

Dipyridamole should be taken on an empty stomach, which is 1 hour before meals. However, you can also take the drug with food if it causes stomach discomfort.

Swallow the medicine whole with the help of a glass of water. Do not chew or crush the medicine. Take the drug regularly so that the effectiveness of the drug is maximized. Do not stop taking the drug if the condition has improved, unless ordered by a doctor.

If it is necessary to take an antacid while on treatment with dipyridamole, take the antacid 1 hour before or 2 hours after taking dipyridamole.

If you forget to take dipyridamole, take it immediately if the break with the next consumption schedule is not too close. When it is close, ignore and do not double the dose.

Store dipyridamole in a closed container in a dry and cool place. Avoid exposure to direct sunlight and keep drugs out of reach of children.

Dipyridamole Interactions with Other Drugs

There are several drug interaction effects that can occur when dipyridamole is used with other drugs, namely:

  • Decreased effect of fludarabine therapy
  • Reduced absorption of dipyridamole when used with antacids
  • Increased levels of adenosine in the blood
  • Increased effect of anticoagulant drugs or other antiplatelet drugs
  • Increased blood pressure lowering (hypotensive) effect of antihypertensive drugs
  • Increased risk of developing myasthenia gravis when used with cholinesterase inhibitors
  • Increased risk of not dilating blood vessels during cardiac radiological examination if used with theophylline, caffeine, or xanthine-derived drugs, such as aminophylline

Dipyridamole Side Effects and Dangers

Side effects that can arise after using dipyridamole are:

  • Dizziness or headache
  • Vomit
  • Stomach ache
  • Diarrhea
  • Hot sensation
  • A feeling of warmth and heat in the neck, face, or chest ( flushing )

Check with your doctor if these side effects don't get better or get worse. See your doctor right away if you have an allergic reaction to a drug or serious side effects, such as:

  • Severe stomach pain, jaundice , or dark urine
  • chest pain , fast or irregular heartbeat,
  • Severe headache, blurred vision, confusion, slurred speech, or weakness on one side of the body
  • Easy bruising
  • Faint
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