Fibrinogen or factor I is a plasma protein that plays an important role in blood clotting. Fibrinogen may be given to treat excessive bleeding due to injury , DIC ( disseminated intravascular coagulation ), or congenital disorders, such as afibrinogenemia or hypofibrinogenemia .
Fibrinogen is naturally produced by the liver and is present in blood plasma . This protein plays a role in the blood clotting process along with thrombin, plasmin, and factor XIIIa. Fibrinogen can be found in blood transfusion products, such as FFP ( fresh frozen plasma ), cryoprecipitate , or in the form of fibrinogen concentrate .
Fibrinogen trademark : Beriplast P Combi-Set
What is Fibrinogen
| class | Prescription drug |
| Category | Blood components |
| Benefit | Overcome fibrinogen deficiency |
| Used by | Adults and children |
| Fibrinogen for pregnant and lactating women | Category N: Not yet categorized. It is not yet known whether fibrinogen is absorbed into breast milk or not. If you are breastfeeding, do not use fibrinogen without consulting your doctor first. |
| Form | Syringes and blood components |
Warning Before Using Fibrinogen
There are several things that you should pay attention to before using fibrinogen, including:
- Tell your doctor about any history of allergies you have. Fibrinogen should not be given to patients who are allergic to this protein.
- Tell your doctor if you are taking certain medications, supplements or herbal products.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
- Tell your doctor if you have had or are currently suffering from a stroke or a blockage in a blood vessel.
- See a doctor immediately if you have an allergic reaction or serious side effects after using fibrinogen.
Dosage and Rules for Use Fibrinogen
Fibrinogen will be given directly by a doctor or medical officer under the supervision of a doctor. The administration of this blood transfusion product will usually be carried out in a health facility or hospital.
Fibrinogen can be found in blood transfusion products such as cryoprecipitate. The dosage can be different depending on the patient's condition. In general, if using cryoprecipitate , the dose is 10 units and can be repeated if needed. Giving 1 unit of cryoprecipitate can increase the amount of fibrinogen by about 100 mg/dL.
Fibrinogen is also available in injectable form. Fibrinogen injection can be done through a vein (intravenous/IV). The dosage will be adjusted according to the patient's condition.
How to Use Fibrinogen Properly
Fibrinogen will be given directly by a doctor or medical officer under the supervision of a doctor. Follow the recommendations given by the doctor while undergoing treatment with fibrinogen.
While using fibrinogen, you may be asked to have regular blood tests.
Interactions of Fibrinogen with Other Drugs
The interaction effects that arise from the use of fibrinogen with other drugs are not yet known. To be on the safe side, tell your doctor if you are taking certain medications, supplements, or herbal products.
Fibrinogen Side Effects and Dangers
While undergoing treatment with fibrinogen, your condition will be monitored by a doctor or medical officer. There are several side effects that can occur after using fibrinogen, namely:
- Fever
- shivers
- Headache
- Nausea and vomiting
Report to your doctor or medical officer if the side effects mentioned above do not subside or get worse.
In addition, the use of fibrinogen can increase the risk of pulmonary embolism, deep vein thrombosis , arterial thrombosis , and myocardial infarction . Tell your doctor right away if you have any symptoms of these conditions or have an allergic reaction after having treatment with fibrinogen.