Fomepizole is a drug to treat ethylene glycol or methanol poisoning. However, in conditions of severe poisoning, the use of this drug must be accompanied by hemodialysis (dialysis therapy).

Fomepizole works by inhibiting enzymes that activate toxic compounds from ethylene glycol and methanol. The initial phase of poisoning can be marked by nausea or vomiting. People who are poisoned by these chemical compounds also look drunk, like staggering, drowsy, restless, or dazed.

If not treated immediately, ethylene glycol poisoning can cause acute kidney failure . This condition can be characterized by infrequent urination, scanty and dark urine, seizures, coma, to death. Meanwhile, severe methanol poisoning can cause blindness.

Fomepizole trademarks: -

What is Fomepizole

class Prescription drugs
Category Antidote (antidote)
Benefit Treating ethylene glycol or methanol poisoning
Used by Mature
Fomepizole for pregnant and lactating women  Category C: Studies in experimental animals show an adverse effect on the fetus, but there are no controlled studies in pregnant women. The drug should only be used if the expected benefit outweighs the risk to the fetus.

It is not known whether fomepizole is absorbed into breast milk or not. Tell your doctor if you are breastfeeding.

Drug form Inject

Warning Before Using Fomepizole

There are several things you need to pay attention to before using fomepizole, namely:

  • Tell your doctor if you have ever experienced allergy symptoms while taking fomepizole.
  • Tell your doctor if you have or currently have kidney disease, liver disease, or difficulty urinating.
  • Tell your doctor if you have recently consumed alcoholic beverages.
  • Inform your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • Tell your doctor if you are taking certain medications, supplements or herbal products, to anticipate drug interactions.
  • Immediately see a doctor if you experience a drug allergic reaction or serious side effects after using fomepizole.

Dosage and Rules for Use Fomepizole

Fomepizole is given by injection into a vein (intravenously/IV). The following are common doses for use of fomepizole in adults to treat ethylene glycol or methanol poisoning:

  • An initial dose of 15 mg/kg is given by slow infusion over 30 minutes, followed by 10 mg/kg every 12 hours for 4 doses. Thereafter, increase the dose to 15 mg/kg every 12 hours until the ethylene glycol or methanol concentration is <20 mg/100 ml.

If ethylene glycol or methanol poisoning is severe and the patient requires hemodialysis, the dose of fomepizole will be increased during dialysis therapy. In addition, to increase the effectiveness of therapy, fomepizole can also be given with vitamin B1 and vitamin B6 infusions.

How to use fomepizole correctly

Injectable fomepizole will be given by a doctor or medical officer under the supervision of a doctor. This drug is used by injection into a vein. In order for the treatment to get maximum results, the use of fomepizole will be closely monitored by a doctor.

Fomepizole Interactions with Other Drugs

Fomepizole can cause interactions with ethanol, which can be found in alcoholic beverages. If fomepizole is used when there is still ethanol in the blood, the risk of side effects from fomepizole and ethanol poisoning is increased.

Side Effects and Dangers of Fomepizole

Some of the side effects that may appear after using fomepizole are:

  • Headache
  • Dizzy
  • Drowsiness
  • Nauseous
  • Vomit
  • No appetite
  • Ringing ears
  • Metallic taste in mouth
  • Feelings like a hangover or hangover , i.e. tiredness, headaches, dizziness and the room is spinning, fast heartbeat, or mood swings

Check with your doctor if the side effects above don't go away or get worse. See a doctor immediately if you have an allergic drug reaction or more serious side effects, such as:

  • Fever
  • Fast or slow heartbeat
  • Low blood pressure
  • seizures
  • Uncontrolled eye movements ( nystagmus )
  • Difficulty urinating
  • Unusual bruising or bleeding
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