Fosfomycin is an antibiotic that is commonly used to treat and prevent urinary tract infections. Injectable fosfomycin can also be used as a drug of last resort to treat infections in joints or bones, meningitis, and pneumonia.

Fosfomycin works by inhibiting the formation of the bacterial cell wall so that the bacteria cannot multiply and die. After entering the blood, fosfomycin will spread throughout the body, especially to the kidneys and bladder. Therefore, this drug is preferred for urinary tract infections.

Fosfomycin is available in granule and injectable form. Please note, this drug cannot be used to treat infections due to viruses.

Fosfomycin trademarks: Focyn, Fosfi, Fosmicin, Fosmidex, Fosfomycin Sodium, Monuril, Novellmycin, Quafos

What is Fosfomycin

class Prescription drugs
Category Antibiotics
Benefit Overcoming urinary tract infections
Used by Mature
Fosfomycin for pregnant and lactating women


Category B: Animal studies have not demonstrated a risk of fosfomycin to the fetus, but there are no controlled studies in pregnant women.

Fosfomycin can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug form Granule and syringe

Warning Before Using Fosfomycin

There are several things you need to pay attention to before using fosfomycin, namely:

  • Do not use fosfomycin if you have an allergy to this drug.
  • Tell your doctor if you have had or are currently suffering from diarrhea , kidney disease, or are having a dialysis procedure .
  • Do not immediately drive a vehicle or do activities that require alertness after taking fosfomycin if this drug makes you dizzy.
  • Do not use this drug in children under 12 years of age.
  • Tell your doctor if you are going to use fosfomycin with certain medications, supplements, or herbal products, in case of drug interactions.
  • Tell your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.
  • Immediately go to the doctor if you have a drug allergic reaction or serious side effects after using fosfomycin.

Dosage and Rules for Use Fosfomycin

The following is the general dosage of fosfomycin based on the patient's condition:

  • Conditions: Urinary tract infections
    3 g as a single dose.
  • Conditions: Prevention of urinary tract infections before urinary tract examination procedures
    3 g consumed 3 hours before the procedure. Followed by a second dose of 3 grams, consumed 24 hours after the procedure.

In addition to oral drug form, fosfomycin is also available in injection form. The dose of fosfomycin in injection form will be given by the doctor based on the severity of the infection and the patient's response to the drug.

How to Take Fosfomycin Properly

Always follow the doctor 's recommendations and read the information on the packaging before starting to take this drug.

Fosfomycin granules need to be taken on an empty stomach, ie 2–3 hours before or after meals. It is recommended to take fosfomycin before going to bed, after urinating.

Dissolve one sachet of fosfomycin granule in half a glass of water. Do not use hot water to dissolve the medication. After it dissolves, immediately consume the drug until it runs out.

Fosfomycin only needs to be consumed once. Usually, complaints will improve 2-3 days later. If your complaint has not improved or has worsened, do not increase the dose of fosfomycin and consult your doctor immediately.

Please note, increasing the dose of fosfomycin will not increase the effectiveness of the drug, but instead increase the risk of side effects.

Store fosfomycin in a closed place away from heat. Do not place this medication in a damp place or in direct sunlight. Keep this medicine out of reach of children.

Fosfomycin Interactions with Other Drugs

The effectiveness of fosfomycin may decrease if this drug is used with certain drugs, such as:

  • Metoclopramide
  • Cisapride
  • Domperidone
  • Bethanechol
  • Purgative

Consult your doctor if you are going to take these drugs together with fosfomycin.

Fosfomycin Side Effects and Dangers

There are several side effects that may occur after consuming fosfomycin, including:

  • Diarrhea
  • Headache
  • Stomach ache
  • Nauseous
  • Dizzy
  • Body feels weak
  • skin rash
  • Have a cold
  • Sore throat
  • back pain
  • vaginal itching or discharge
  • Pain during menstruation

Consult a doctor if these side effects do not improve. See your doctor right away if you have an allergic drug reaction or a more serious side effect, such as severe or bloody diarrhea accompanied by fever , shortness of breath, dark urine, swelling in your feet and ankles, or jaundice .

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