Gliclazide is a drug to control blood sugar levels in patients with type 2 diabetes mellitus. The use of this drug must be combined with a healthy diet and regular exercise. Gliclazide is available in tablet form and can only be consumed based on a doctor's prescription.

Gliclazide works by stimulating the pancreas to produce more insulin , a hormone that helps control blood sugar levels. Insulin will help the body to enter blood sugar into the cells of the body so that the level of sugar in the blood can go down.

Well-controlled blood sugar levels can reduce the risk of diabetes complications, such as eye damage ( diabetic retinopathy ), nerve damage ( diabetic neuropathy ), kidney damage ( diabetic nephropathy ), stroke, or heart attack .

Gliclazide trademarks: Diamicron, Linodiab, Gliclazide, Glidex, Glucodex, Glucored, Glukolos, Xepabet

What is Gliclazide

Group Prescription drugs
Category Antidiabetes Sulfonylureas
Benefits Controlling blood sugar levels in patients with type 2 diabetes mellitus
Consumed by Adults
Gliclazide for pregnant and lactating women Category C: Studies on experimental animals show side effects on the fetus, but there are no controlled studies on pregnant women.

This drug may cause a lack of blood sugar in the fetus. Medicines can only be used if the magnitude of the expected benefit exceeds the magnitude of the risk to the fetus.

It is not yet known whether gliclazide can be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without first consulting your doctor.

Drug form Tablets, tablets come off slowly

Warnings Before Consuming Gliclazide

There are several things that should be considered before consuming gliclazide, among others:

  • Do not consume gliclazide if you are allergic to this drug or drugs that include sulfonamides and other sulfonylureas.
  • Tell your doctor if you are suffering from kidney disease, liver disease, porphyria , glucose-6-phosphate dehydrogenase ( G6PD ) deficiency disease, or type 1 diabetes.
  • Avoid exposure to direct sunlight and use sunscreen if going out during the day, because glycazie can make your skin more sensitive to sunlight.
  • Tell your doctor that you are taking gliclazide if you plan to undergo dental treatment or surgery.
  • Do not consume alcoholic beverages during treatment with gliclazide.
  • Tell your doctor if you are pregnant, breastfeeding, or planning to become pregnant.
  • Inform the doctor if you are taking certain drugs, supplements, or herbal products, to anticipate the occurrence of drug interactions.
  • See a doctor immediately if you experience a drug allergic reaction or overdose after consuming gliclazide.

Dosage and Administration of Gliclazide

The dose of gliclazide will be adjusted according to the patient's blood sugar level. This medicine is available in the form of conventional tablets and delayed-release tablets. The following is the general dosage of gliclazide based on the form of the drug:

  • Conventional tablets or regular tablets
    Initial dose 40–80 mg per day, once a day, at breakfast. The dose can be increased gradually up to 320 mg per day if needed. If the dose is more than 160 mg per day, the dose needs to be divided into 2 administrations, namely at breakfast and at dinner.
  • Modified- release tablets or slow
    -release tablets Initial dose 30 mg per day. The dose can be increased gradually up to a maximum of 120 mg per day if needed.

How to Consume Gliclazide Correctly

Follow the doctor 's advice and read the instructions for use on the package before using gliclazide.

Gliclazide can be consumed with food or immediately after eating. Try to consume this medicine at the same time every day so that the benefits are maximum.

If you are advised to consume gliclazide in the form of delayed-release tablets, swallow the medicine whole. Do not split or chew, let alone crush the tablet.

If you forget to take gliclazide, immediately take the medicine as soon as you remember if the break with the next schedule is not too close. If it is close, ignore the missed dose and do not double the next dose.

While taking gliclazide, tell your doctor if you experience severe injury, fever, or symptoms of infection, such as cough, runny nose, diarrhea, and sore throat. These conditions can affect blood sugar levels. If necessary, the doctor will adjust the dose of gliclazide to your condition.

Consuming gliclazide can sometimes cause hypoglycemia or low blood sugar. To prevent this, eat regularly with balanced nutrition. If necessary, consult with a nutritionist about safe eating patterns and foods for people with diabetes.

Store gliclazide in a cool, dry place, away from direct sunlight. Keep this medicine out of the reach of children.

Interactions of Gliclazide with Other Drugs

Gliclazide can cause several drug interaction effects if used with other drugs, among others:

  • Increased risk of hypoglycemia if used with beta-blockers , fluconazole, ACE inhibitors , MAOIs, sulfonamides , clarithromycin, H2 antagonists , and NSAIDs
  • Increased drug effect in lowering blood sugar if used with other antidiabetic drugs
  • Decreased effectiveness of gliclazide if used with danazol, terbutaline, chlorpromazine, corticosteroids , salbutamol, barbiturates , and estrogen
  • Increased risk of blood sugar instability if used with fluoroquinolones
  • Increased risk of bleeding if used with warfarin

Side Effects and Dangers of Gliclazide

Some side effects that may appear after consuming gliclazide are:

  • Nausea
  • Vomiting
  • Heartburn
  • Constipation
  • Diarrhea
  • Weight gain

Check with your doctor if the side effects that have been mentioned above do not improve or even get worse.

Gliclazide can also cause hypoglycemia . Immediately consume foods containing sugar, such as candy, honey, or sweet tea, if you experience any of the following symptoms:

  • Hungry
  • Turn
  • Drowsy
  • Headache
  • Drown
  • Excessive sweating
  • Hard to concentrate
  • Trembling

See a doctor immediately if you experience a drug allergic reaction or more serious side effects, such as:

  • Fast or irregular heartbeat
  • Liver disorders, such as jaundice
  • Feces are black and shaped like liquid asphalt
  • Vomiting with residue like coffee grounds
  • Blood disorders, which can be marked by bruising and bleeding that does not improve, sore throat, or fever
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