Isocarboxazid is used to relieve symptoms of depression, including anxiety, panic disorder, or excessive fear. Isocarboxazid should not be used carelessly and must be prescribed by a doctor.

Isocarboxazid works by inhibiting the monoamine oxidase enzyme. This enzyme destroys several types of neurotransmitters in the brain, which are natural chemicals that regulate mood, such as norepinephrine, serotonin, and dopamine.

When isocarboxazid inhibits the monoamine oxidase enzyme , the levels of the above neurotransmitters will increase, so that the symptoms of depression can subside. However, this drug is usually only used when other antidepressants have not shown satisfactory results.

Isocarboxazid trademarks : -

What is Isocarboxazid

class Prescription drug
Category Monoamine oxidase inhibitors ( MAOIs )
Benefit Relieves symptoms of depression
Consumed by Mature
Isocarboxazid for pregnant and lactating women


Category C: Animal studies have shown an adverse effect on the fetus, but there have been no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

It is not yet known whether isocarboxazid can be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug form Tablet

Precautions Before Taking Isocarboxazid

Isocarboxazid should only be used as prescribed by a doctor. Here are some things you need to pay attention to before taking isocarboxazid:

  • Tell your doctor about any history of allergies you have. Isocarboxazid should not be given to patients who are allergic to this drug.
  • Tell your doctor if you have had or currently have pheochromocytoma , stroke, coronary heart disease , heart failure, diabetes, epilepsy, hypertension, thyroid disease, or another mental disorder, such as schizophrenia or bipolar disorder .
  • Tell your doctor if in the last 14 days you have recently used an MAOI class of drugs, such as phenelzine. Isocarboxazid should not be used, if you are taking or have recently used this drug.
  • Tell your doctor if you have used any medications, supplements or herbal products in the past 5 weeks.
  • Avoid driving a vehicle or doing activities that require alertness while on treatment with isocarboxazid, because this drug can cause dizziness and drowsiness .
  • Do not consume alcoholic beverages or foods that contain high levels of tyramine, such as cheese and avocados, while you are taking isocarboxazid because this will increase the risk of side effects.
  • Tell your doctor that you are taking isocarboxazid before having any laboratory tests or certain medical procedures.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • See a doctor immediately if you have an allergic drug reaction, serious side effects, or an overdose after taking isocarboxazid.

Dosage and Rules for Use of Isocarboxazid

The dose of isocarboxazid varies for each patient. The doctor will determine the dose according to the patient's age, health condition, and body response. Here is the explanation:

Purpose: Relieves symptoms of depression

  • Adult: Initial dose is 30 mg per day. Dosage may be increased up to 60 mg after 4 weeks.
  • Elderly: 5–10 mg per day.

How to Take Isocarboxazid Correctly

Take isocarboxazid according to doctor's instructions and instructions on the drug packaging. Do not change the dosage without consulting your doctor first.

If you forget to take isocarboxazid, take it as soon as you remember. If it is nearing time for your next dose, skip the missed dose. Do not double the dose of isocarboxazid to make up for a missed dose.

Check blood pressure regularly while taking isocarboxazid to monitor developments in body condition.

Store isocarboxazid in a place protected from direct sunlight. Keep this drug out of reach of children.

Isocarboxazid Interactions with Other Drugs

There are several drug interaction effects that can occur if isocarboxazid is taken with certain drugs, including:

  • Increased risk of developing serotonin syndrome if taken with MAOI, tricyclic , or SSRI antidepressant drugs
  • Increased risk of fatal side effects, such as fainting or coma if taken with hydrocodone or pethidine
  • Increased risk of developing hypertension if taken with halothane or benzphetamine
  • Increased action of metaraminol, fenfluramine, dopamine, or levodopa

Isocarboxazid Side Effects and Dangers

Some of the side effects that can arise after consuming isocarboxazid are:

  • Orthostatic hypotension
  • Constipation
  • Dry mouth
  • Spinning diarrhea
  • Dizzy
  • Drowsiness
  • Sleep disturbance ( insomnia )
  • Tremors

Check with your doctor if the complaints mentioned above don't go away or get worse.

Also report to the doctor if the symptoms of depression worsen, for example, the desire to commit suicide or self-harm arises. This can occur in patients younger than 25 years who are taking antidepressants for the first time.

In addition, stop taking isocarboxazid immediately and seek medical attention if you experience an allergic drug reaction or serious side effects, such as:

  • Sudden headache
  • Stiffness or pain in the neck
  • The eyes are suddenly sensitive to light
  • Heart rate is fast, slow, or feels irregular
  • Excessive fatigue
  • Tingling , numbness, or weakness in the hands or feet
  • Loss of body balance
  • Severe stomach pain, dark urine, or jaundice
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