Isoxsuprine is a drug for treating diseases with impaired blood flow, such as Raynaud's disease, arteriosclerosis, Buerger's disease , or cerebral vascular insufficiency. This drug is available in tablet and injection form.
Isoxsuprine works by dilating blood vessels so that blood can flow more smoothly to body tissues, including the hands, feet and brain. This way of working can help reduce the symptoms of numbness , tingling, and memory loss that occur due to a lack of oxygen intake in the tissues.
In addition to dilating blood vessels, isoxsuprine also has a relaxing effect on the uterine muscles (tokolytic). Therefore, this drug can also be used to reduce contractions in pregnancies with a risk of preterm labor.
Merek dagang isoxsuprine: Duvadilan, Hystolan, Isoxsuprine Hydrochloride, Proterine, Simduva, Tonotan, Uterlax
What is Isoxsuprine
Treat blood flow disorders, such as Raynaud's disease , arteriosclerosis, Buerger's disease , or cerebral vascular insufficiency.
Reducing contractions in pregnancies with a risk of preterm labour
|Isoxsuprine for pregnant and lactating women||
Category C: Studies in animals have shown an adverse effect on the fetus, but there have been no controlled studies in pregnant women.
Drugs should only be used if the expected benefit outweighs the risk to the fetus.
It is not known whether isoxsuprine is absorbed into breast milk or not . If you are breastfeeding, do not use this medication without your doctor 's approval .
|Form||Tablets and injections|
Precautions Before Using Isoxsuprine
Isoxsuprine should not be used carelessly. There are several things that you should pay attention to before starting treatment with isoxsuprine, including:
- Do not use isoxsuprine if you are allergic to this drug.
- Do not use isoxsuprine if you have abnormal bleeding.
- Inform your doctor if you have recently given birth. Isoxsuprine should not be used after delivery.
- Tell your doctor if you have or currently have a bleeding disorder, glaucoma , or heart disease.
- Tell your doctor if you have recently had a heart attack, chest pain , or stroke .
- Do not immediately drive or do other activities that require alertness after taking isoxsuprine if this drug causes dizziness.
- Avoid smoking and consuming alcoholic beverages while undergoing treatment with isoxsuprine.
- Consult with your doctor about the side effects that need to be anticipated if isoxsuprine is consumed by seniors over 65 years.
- Tell your doctor about using isoxsuprine if you are planning to have surgery or any other medical procedure, including dental surgery.
- Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
- Tell your doctor if you are taking other medications, including supplements and herbal products, to prevent drug interactions.
- Immediately see a doctor if you experience a drug allergic reaction or serious side effects after taking isoxsuprine.
Isoxsuprine Dosage and Rules for Use
Isoxsuprine can be given in tablet or injection form. The dose of isoxsuprine will be given by the doctor according to the condition and response of the patient's body to the drug.
The following is isoxsuprine dosage for adult patients based on the purpose of treatment:
Purpose: Overcome blood circulation disorders
- Tablets: 10–20 mg, 3–4 times daily.
- Injection: Dose of 10 mg, 3 times a day, given through a vein (IV/intravenous) or arterial vein (intraarterial/IA).
Purpose: Reduce uterine contractions in pregnancies with a risk of preterm labor
- Injectable: Initially 0.2–0.3 mg per minute by infusion into a vein (IV/intravenously). The maximum dose is 0.5 mg per minute. The infusion is continued until the contractions stop. The doctor will give another 10 mg of isoxsuprine by injection into the muscle (intramuscular / IM) the next 3 hours.
How to Use Isoxsuprine Properly
Isoxsuprine injection will be given directly by a doctor or medical officer under the supervision of a doctor. Isoxsuprine injection can be given by infusion or injection into a vein, artery, or muscle.
If you are prescribed isoxsuprine tablets, follow your doctor's advice and read the information on the drug packaging before starting to take them. Do not increase or decrease your dose without your doctor's approval.
Isoxsuprine tablets can be taken before or after meals. To avoid nausea, you can take it with food, milk or antacids. Swallow the tablet with the help of a glass of water.
Take this medication at the same time every day. Do not stop taking isoxsuprine even if you feel better, unless advised by your doctor.
If you forget to take isoxsuprine, take this drug as soon as you remember. However, if the next scheduled medication is near, ignore the missed dose and do not double the next dose.
Follow the control schedule given by the doctor. While on treatment with isoxsuprine, you may be asked to have a blood test. This is done to monitor the progress of therapy and side effects that may arise from the use of this drug.
Store isoxsuprine at room temperature. Do not store this medicine in a damp place or be exposed to direct sunlight. Keep isoxuprine out of reach of children.
Isoxsuprine Interactions with Other Drugs
Isoxsuprine can cause drug interactions when used with other drugs. Here are some interactions between drugs that can occur:
- Increased risk of side effects, such as headache, dizziness, irregular heartbeat, and fainting, when used with tizanidine
- Increased risk of developing low blood pressure (hypotension) when used with MAOI antidepressants , antipsychotic drugs , or sildenafil
- Increased risk of developing heart palpitations ( palpitations ), drop in blood pressure, and swelling, when used with topical minoxidil
- Increased risk of dehydration and hypotension when used with the antidiabetic drugs canagliflozin or empagliflozin
Isoxsuprine Side Effects and Dangers
Some of the side effects that can occur after using isoxsuprine are:
- Warm feeling in the face, neck, or chest ( flushing )
- Nausea or vomiting
- Stomach ache
- Body feels weak
Consult a doctor if the side effects above do not subside or even get worse. Immediately see a doctor if you experience a drug allergic reaction or serious side effects, such as:
- Fast heartbeat or pounding
- Chest pain
- Difficulty breathing
- Dizzy to the point of feeling faint