Lansoprazole is a drug to treat conditions related to increased stomach acid. This drug is commonly used in people with stomach ulcers, GERD (gastro esophageal reflux disease), erosive esophagitis, and Zollinger-Ellison syndrome.

Lansoprazole can reduce stomach acid production and relieve symptoms due to increased stomach acid, such as a burning sensation in the chest, sour mouth, and nausea and vomiting. That way, damage or complications that can be caused by high stomach acid can be prevented.

Lansoprazole can also be used to treat complications that have already occurred, such as erosive esophagitis and stomach ulcers. With reduced stomach acid, further damage can be prevented and tissues can heal more quickly.

Lansoprazole trademarks : Compraz, Digest, Dobrizol, Gastrolan, Inhipraz, Laz, Nufaprazole, Lagas, Lancid, Lanpracid, Lansoprazole, Lanzogra, Laproton, Loprezol, Lanvell, Prosogan FD, Pysolan, Sopralan 30, and Zolesco.

What is Lansoprazole?

class Proton pump inhibitor
Category Over-the-counter and prescription drugs
Benefit Reducing excess stomach acid production
Used by Adults and children ≥1 year of age
Lansoprazole for pregnant and lactating women Category B : Animal studies have not demonstrated a risk to the fetus, but there are no controlled studies in pregnant women. It is not known whether lansoprazole is absorbed into breast milk. If you are breastfeeding, do not take this drug without consulting your doctor.
Drug form Capsules, tablets, injections.

Warning Before Using Lansoprazole

There are several things that need to be considered before taking lansoprazole, including:

  • Do not use lansoprazole if you are allergic to it or to other proton pump inhibitor class drugs, such as omeprazole and pantoprazole.
  • Consult your doctor about using lansoprazole if you have or currently have liver problems , lupus , osteoporosis, osteopenia, hypomagnesemia , or phenylketonuria .
  • Consult your doctor about using lansoprazole if you are experiencing bloody bowel movements, black bowel movements, vomiting like coffee grounds, heartburn for more than 3 months, frequent chest pain accompanied by heartburn , or weight loss for no apparent reason.
  • Tell your doctor that you are using lansoprazole if you are planning to have an endoscopy or any other medical procedure.
  • Tell your doctor if you are taking any other medications, including supplements and herbal products.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • Immediately consult a doctor if you experience an allergic drug reaction or overdose after taking lansoprazole.

Dosage and Rules for Use Lansoprazole

The dose of lansoprazole can vary for each patient, depending on the form of the drug, the patient's age, and the condition you want to treat. The following are lansoprazole dosages grouped by drug form:

Lansoprazole tablets and capsules 

Condition: Acid reflux disease (GERD)

  • Adult: 15 mg once daily for 8 wk.
  • Children ≥12 years: 15 mg once daily for up to 8 weeks.

Condition: GERD accompanied by reflux esophagitis or erosive esophagitis

  • Adults and children >12 years : 30 mg once daily for 8–16 weeks. Maintenance dose: 15 mg per day.
  • Children aged 1–12 years with body weight (BB) > 30 kg : 30 mg, 1 time per day for 8–12 weeks.
  • Children aged 1–12 years with body weight (BB) ≤30 kg : 15 mg, 1 time per day for 8–12 weeks.

Condition: Stomach ulcer or duodenal ulcer

  • Adult: 30 mg once daily for 2–4 weeks for duodenal ulcers or for 4–8 weeks for gastric ulcers.

Condition: Stomach ulcer caused by infection with Helicobacter pylori

  • Adult: 30 mg, 2–3 times daily, for 7–14 days. Treatment is combined with clarithromycin and amoxicillin or metronidazole antibiotics.

Condition: Stomach ulcer due to use of non-steroidal anti-inflammatory drugs ( NSAIDs )

  • Adult: 15–30 mg once daily for 4–8 wk.

Condition : Zollinger-Ellison syndrome

  • Adult: Initially 60 mg once daily. If necessary, may increase to 90 mg twice daily depending on patient's response to treatment.
  • Elderly: Maximum 30 mg per day.

Injectable lansoprazole

Condition: Reflux esophagitis or erosive esophagitis

  • Adult: 30 mg once daily by infusion over 30 minutes, up to 7 days before starting lansoprazole tablets or capsules.

How to use Lansoprazole correctly

Follow the doctor's recommendations and read the instructions for use listed on the drug packaging. Do not reduce or increase your dose or use lansoprazole for more than the time recommended by your doctor.

The injection type of lansoprazole will be given directly by a doctor or medical officer under the supervision of a doctor by injecting it into a vein (intravenously) or through an infusion.

Take lansoprazole tablets or capsules before meals. Swallow the medicine whole with a glass of water. Do not chew, split or crush the tablet.

It is recommended to take lansoprazole capsules or tablets at the same time every day for maximum treatment effect. This medicine usually needs to be taken in the morning.

Store lansoprazole tablets or capsules in a closed container in a cool room. Do not store it in a damp place or in direct sunlight. Keep this drug out of reach of children.

Lansoprazole Interactions with Other Drugs

The following are interaction effects that can occur when lansoprazole is used with certain drugs:

  • Reducing the effectiveness of the drugs rilpivirine, atazanavir, or nelfinavir in fighting HIV, so that they can endanger people with HIV
  • Increased risk of bleeding if taken with warfarin
  • Increased risk of developing hypomagnesemia when used with diuretic drugs
  • Increased risk of side effects with lansoprazole when used with fluvoxamine
  • Increased risk of side effects from methotrexate, digoxin , or tacrolimus
  • Decreased effectiveness of lansoprazole when used with rifampicin, antacids , sucralfate, or St. John's Wort
  • Decreased effectiveness of clopidogrel, theophylline, ketoconazole, and itraconazole drugs

Lansoprazole Side Effects and Dangers

Side effects that may occur after using lansoprazole are nausea, flatulence, abdominal pain, constipation or even diarrhea , headaches, or dizziness. These side effects are generally mild and may go away after treatment is finished.

Meanwhile, long-term use of lansoprazole has the risk of causing serious side effects, such as:

  • Symptoms of hypomagnesemia , such as severe muscle cramps, heart rhythm disturbances, tremors, or seizures
  • Lupus symptoms , such as skin rashes that often occur on the cheeks and nose, or joint pain and stiffness
  • Symptoms of deficiency (deficiency) of vitamin B12 , such as fatigue and feeling weak, pale skin, palpitations, shortness of breath, tingling, blurred vision
  • Symptoms of liver disease, such as yellow skin and eye color, dark colored urine, or pale stools
  • Symptoms of kidney disease, such as pain in the lower back, pain when urinating, cloudy or blood-tinged urine
  • Symptoms of osteoporosis , such as back pain, hunchbacked posture, reduced height, or fractures in mild to moderate injuries

Immediately consult a doctor if you experience an allergic reaction, such as an itchy rash, swelling of the lips and eyes, or difficulty breathing, after using lansoprazole.

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