Linagliptin is a drug to lower blood sugar levels in type 2 diabetics. To increase its effectiveness, the use of this drug should be accompanied by changes in healthy eating patterns and regular exercise.
Linagliptin works by increasing the release of insulin, especially after meals. In addition, this drug can also reduce the production of blood sugar from the liver. The way it works can lower blood sugar levels in type 2 diabetics.
Linagliptin can be used as a single drug or in combination with other antidiabetic drugs, such as metformin or empagliflozin. Although this drug can lower blood sugar, linagliptin cannot be used to overcome high blood sugar levels in type 1 diabetes or diabetic ketoacidosis.
Brand names of linagliptin: Glyxambi, Tidyp, Trajenta, Trajenta Duo
What is Linagliptin
| Group | Prescription drugs |
| Category | Antidiabetic |
| Benefits | Controlling blood sugar levels in type 2 diabetics |
| Consumed by | Adults |
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Linagliptin for pregnant and lactating women |
Category C : Studies on experimental animals show side effects on the fetus, but there are no controlled studies on pregnant women.
Medicines can only be used if the magnitude of the expected benefit exceeds the magnitude of the risk to the fetus. It is not yet known whether linagliptin can be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without first consulting your doctor. |
| Drug form | Film-coated tablets |
Warnings Before Consuming Linagliptin
Linagliptin should not be used indiscriminately. The following are things to consider before consuming linagliptin:
- Do not take linagliptin if you are allergic to this medicine. Tell your doctor about any allergies you have.
- Tell your doctor if you have had or are currently suffering from pancreatitis , gallstones, heart failure, heart disease, kidney disease, or high triglycerides .
- Do not immediately drive or operate heavy machinery after consuming linagliptin, because this drug can cause drowsiness, dizziness, or blurred vision.
- Do not consume alcoholic beverages during treatment with linagliptin, as it can increase the risk of low sugar levels ( hypoglycemia ). Tell your doctor if you have difficulty reducing your consumption of alcoholic beverages or are addicted to alcohol .
- Do not give linagliptin to children under 18 years of age.
- Tell your doctor that you are taking linagliptin if you are scheduled to undergo surgery or medical procedures, including dental surgery.
- Tell your doctor if you are taking other antidiabetic drugs. Also inform when using other types of drugs, including supplements and herbal products, to anticipate drug interactions.
- Tell your doctor if you have a fever, infection, serious injury, or have recently undergone surgery. These things can affect blood sugar levels so the dose of linagliptin may need to be adjusted.
- Tell your doctor if you are pregnant, breastfeeding, or planning to become pregnant.
- See a doctor immediately if you experience a drug allergic reaction , serious side effects, or overdose after consuming linagliptin.
Dosage and Administration of Linagliptin
The general dose of linagliptin to control blood sugar levels in type 2 diabetics is 5 mg, once a day. The doctor can adjust the dose based on the health condition, the body's response to the medicine, and the medicine being consumed by the patient.
How to Consume Linagliptin Correctly
Follow the doctor 's advice and always read the instructions on the medicine package when taking linagliptin. Do not reduce, increase, or stop the medication without the doctor's instructions.
Linagliptin can be consumed before or after meals. Swallow the tablet whole with water. Try to consume linagliptin at the same time every day for maximum benefits.
If you forget to take linagliptin, immediately take the medicine as soon as you remember if the break with the next schedule is not too close. If it is close, ignore the missed dose and do not double the next dose.
Perform controls according to the schedule given by the doctor so that your condition and response to therapy can be properly monitored.
Store linagliptin at room temperature, in a dry place, and away from direct sunlight. Keep out of the reach of children.
Interactions of Linagliptin with Other Drugs
Interactions that can occur if linagliptin is used with certain drugs are:
- Increased risk of hypoglycemia if used with insulin or sulfonylurea antidiabetic drugs
- Decreased effectiveness of linagliptin if used with rifampicin , phenytoin, phenobarbital, or carbamazepine
- Increased risk of hypoglycemia if used together with ketoconazole or itraconazole
- Increased risk of hypoglycemia or hyperglycemia if used with gatifloxacin or ritonavir
Side Effects and Dangers of Linagliptin
Linagliptin can cause hypoglycemia. Immediately consume foods containing sugar, such as candy, fruit juice, honey, or sweet tea, if you experience any of the following symptoms:
- Hungry
- Pale
- Turn
- Heart rate felt fast
- Tired
- Hard to concentrate
- Tingling
- Easily offended
- Bewildered
- Anxious
- Trembling
If the symptoms have not improved after three times of giving sugar, immediately go to the IGD for further treatment.
Other side effects that may arise after consuming linagliptin are:
- Cold, stuffy nose, sneezing, or sore throat
- Cough
- Diarrhea
Check with your doctor if the side effects do not improve or worsen. See a doctor immediately if you experience a drug allergic reaction or the following serious side effects after taking linagliptin:
- Joint pain until unable to move
- Heart failure , which is characterized by shortness of breath or sudden weight gain
- Acute pancreatitis , which is characterized by nausea and vomiting, fever, or abdominal pain that spreads to the back
- Jaundice