Lisinopril is a drug to lower blood pressure in hypertensive patients. By controlling blood pressure, complications such as congestive heart failure or stroke can be reduced.

In addition to lowering blood pressure, lisinopril can also be used in the treatment of heart failure or post-heart attack. Lisinopril works by widening the blood vessels, so that the blood can flow more smoothly and ease the workload of the heart in pumping blood.

It should be remembered that lisinopril only helps to control hypertension and prevent the occurrence of complications due to hypertension, but not to cure hypertension.

Lisinopril trademarks: Inhitril, Lisinopril Dihydrate, Lipril, Noperten, Nopril

What Is Lisinopril

Group Prescription drugs
Category ACE inhibitors
Benefits Lowering high blood pressure in hypertension and treating heart failure
Consumed by Adults and children aged >6 years
Lisinopril for pregnant and lactating women Category D: There is positive evidence of risk to the human fetus, but the magnitude of the benefit may outweigh the risk, for example to overcome a life-threatening situation.

Lisinopril is not known to be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without first consulting your doctor.

Drug form Tablets

Warnings Before Consuming Lisinopril

Lisinopril can only be used according to a doctor's prescription. Some things to consider before consuming lisinopril are:

  • Do not take lisinopril if you are allergic to this drug or other ACE inhibitor drugs , such as enalapril, captopril, ramipril, or trandolapril.
  • Tell your doctor if you are taking certain medications, supplements, or herbal products. Be sure to tell your doctor if you have recently taken medication for heart disease, such as sacubitril or are taking potassium supplements.
  • Tell your doctor if you are suffering from diabetes and are undergoing treatment with aliskiren. Lisinopril should not be given to patients with these conditions.
  • Tell your doctor if you have had or are suffering from angioedema , diabetes, heart disease, liver disease, lupus , or high levels of potassium in the blood.
  • Tell your doctor if you are pregnant, breastfeeding, or planning to become pregnant.
  • Tell the doctor that you are undergoing treatment with lisinopril before undergoing certain medical procedures or operations.
  • See a doctor immediately if an allergic drug reaction , serious side effect, or overdose occurs after consuming lisinopril.

Dosage and Administration of Lisinopril

The dose of lisinopril given by the doctor depends on the patient's health condition and age. Here is the explanation:

Condition: Hypertension

  • Adults: Initial dose 10 mg once a day. The treatment dose is 20 mg once a day, which can be increased to a maximum of 80 mg per day. For patients with renovascular hypertension and severe hypertension, the dose can be started with 2.5–5 mg once a day.
  • Children aged 6–16 years: The initial dose for children weighing 20–50 kg is 2.5 mg, once a day. The maximum dose is 20 mg per day. The initial dose for children weighing ≥50 kg is 5 mg once a day. The maximum dose is 40 mg per day.

Condition: Diabetic nephropathy

  • Adults: 10 mg once daily. The dose can be increased to 20 mg once a day, until reaching a diastolic pressure <90 mmHg.

Condition: Heart failure

  • Adults: Initial dose 2.5 mg once a day. The dose can be increased to 20–40 mg, with an interval of 4 weeks based on the response of the patient's body.

Condition: Post heart attack

  • Adults: Initial dose 5 mg once a day, within 24 hours after the onset of symptoms. The treatment dose is 10 mg once a day for 6 weeks.

How to Consume Lisinopril Correctly

Follow the doctor 's recommendations and read the instructions on the label of the lisinopril package before starting to consume it. Do not change the dose without first consulting a doctor.

Lisinopril can be taken with or without food. Drink a glass of water to swallow lisinopril. Consume lisinopril according to the prescribed dose. Do not increase or decrease the dose without first consulting a doctor.

Consume lisinopril at the same time every day to obtain maximum results. If you forget to take lisinopril, immediately take the medicine when the interval with the next dose is not too close. Ignore and do not double the dose when it is close to the next dose schedule.

Do not stop taking lisinopril without consulting your doctor first, even if your condition feels better

To control blood pressure, you are also advised to adopt a low-salt and low-fat diet, exercise regularly , not smoke, and limit the consumption of alcoholic beverages.

Perform routine blood pressure checks while taking lisinopril to monitor the development of the body's condition.

Store lisinopril at room temperature and in a closed container to avoid exposure to direct sunlight, and keep out of the reach of children.

Interactions of Lisinopril with Other Drugs

There are several interaction effects that can occur if lisinopril is consumed with certain drugs, among others:

  • Increased risk of angioedema if used with sirolimus, alteplase , sacubitril, or racecadotril
  • Increased risk of hypotension, hyperkalemia, and renal failure if used with aliskiren
  • Increased risk of anaphylactic reaction if used with dextran
  • Increased blood-lowering effects of lisinopril if used with diuretics or other antihypertensive drugs
  • Increased risk of hypoglycemia if used with insulin or antidiabetic drugs
  • Increased levels and toxic effects of lithium in the blood
  • Increased risk of kidney damage and decreased antihypertensive effect of lisinopril if used with nonsteroidal anti-inflammatory drugs ( NSAIDs )
  • Increased risk of hyperkalemia if used with potassium supplements or potassium- sparing diuretics

Side Effects and Dangers of Lisinopril

Lisinopril can cause a drop in blood pressure resulting in hypotension. In addition, there are several side effects that can occur after consuming lisinopril, including:

  • Turn
  • Headache
  • Nausea and vomiting
  • Dry cough
  • Unusually tired
  • Stuffy nose or runny nose
  • Decreased sexual desire

Check with a doctor if the complaints mentioned above do not subside or get worse. Contact your doctor immediately if you experience an allergic reaction to the drug or experience more serious side effects, such as:

  • Pass out
  • Very heavy drowning
  • Irregular heartbeat or palpitations
  • Severe nausea or vomiting
  • Loss of appetite
  • Severe abdominal pain
  • Jaundice
  • Swelling in the legs or arms
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