Methohexital

Methohexital is a drug used as an anesthetic to induce (start) or maintain anesthesia, during surgical procedures. This medicine will be given by a doctor or medical officer under the supervision of a doctor at the hospital.  

Methohexital belongs to the group of barbiturates. This drug will increase the work of gamma-aminobutyric acid (GABA), a neurotransmitter that plays a role in slowing down the activity of the brain and central nervous system.

Methohexital trademarks: -

What is Methohexital

Warning Before Using Methohexital

Methohexital will be given by a doctor or medical officer under the supervision of a doctor at the hospital. There are several things that must be considered before using methohexital, namely:

• Tell your doctor about any history of allergies you have. Methohexital should not be given to patients who are allergic to it or to other barbitural drugs, such as phenobarbital .
• Tell your doctor if you have porphyria . Methohexital should not be used by patients with these conditions.
• Tell your doctor if you have heart disease , hypotension, hypertension , severe anaemia, obesity , liver disease, kidney disease , disease of the glands or endocrine system, lung or respiratory disease, including COPD or asthma .
• Tell your doctor if you are taking certain supplements, herbal products, or medications.
• Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
• Methohexital will be given in the hospital. Follow the doctor's recommendations before, during and after the injection of methohexital.
• Tell your doctor right away if you have an allergic drug reaction , more serious side effects, or an overdose, after having methohexital injection.

Dosage and Rules for Use of Methohexital

Methohexital will be injected directly by a doctor or medical officer under the supervision of a doctor at the hospital. During the injection the doctor will monitor the patient's condition. In general, the following are common doses of methohexital:

Goal: Initiate (induction) of anesthesia

• The dose for children aged > 1 year in a 1% solution is 25 mg/kg. The drug will be injected into the muscle (intramuscular). This medication is also sometimes given rectally or rectally.
• The dose for adults is 50–120 mg at a rate of 1 ml per 5 seconds. The drug will be injected into a vein (intravenously/IV).

Purpose: Anesthesia during surgery

• The dose for adults is 1–1.5 mg/kg. The medicine will be injected into a vein. Maintenance dose 20–40 mg IV injectable every 4–7 minutes or continuous infusion of 0.2% solution at 3 ml/min.

How to Use Methohexital Properly

Injectable methohexital will be given by a doctor or medical officer under the supervision of a doctor in a hospital with strict supervision. This medication may be given by injection into a muscle or vein, or by infusion into a vein.

Tell your doctor right away if you feel a burning sensation, pain, or swelling around the injected or infused area.

After the methohexital is given, the doctor or medical staff will monitor your breathing, blood pressure, oxygen levels, and vital organs. Your condition will also be monitored closely.

Drowsiness after being anesthetized with methohexital will still be felt for up to 8-12 hours. Follow the advice and recommendations given by the doctor before, during and after the injection of methohexital.

Methohexital Interactions with Other Drugs

There are several drug interactions that can occur if methohexital is used with certain drugs, including:

• Decreased effect of methohexital when used with phenytoin
• Increased risk of developing hypotension when used with ACE inhibitors , beta blockers , antipsychotics , or monoamine oxidase inhibitors ( MAOIs )
• Increased risk of side effects if used with drugs that have a depressing effect on the central nervous system
• Decreased effectiveness of anticoagulant drugs, such as warfarin

In addition, if used with alcoholic beverages or products containing propylene glycol can increase the risk of side effects.

Side Effects and Dangers of Methohexital

The doctor will monitor your condition before, during and after the methohexital injection. There are several side effects that can occur after using methohexital, including:

• Drowsiness
• It's hard to breathe
• Muscle twitches
• Cough or hiccups
• Nausea, vomiting , or stomach pain
• Swelling or irritation at the injection site
• Chills

In addition, there are some more serious side effects that can occur after injecting this drug, such as difficulty breathing, stopping breathing, convulsions , fainting, depression , anxiety, or anxiety.

The doctor will treat you if you experience the side effects mentioned above or experience an allergic drug reaction, after injection of methohexital.