Methylergometrine

Methylergometrine is a drug to prevent and treat postpartum hemorrhage . This drug can also be used to treat bleeding after a miscarriage.

Methylergometrine is also known as methylergonovine or methergine. This drug works by stimulating the uterine muscles to contract more forcefully so that the blood vessels can close. As the contractions increase, the bleeding will also stop more quickly.

M ethylergometrine trademarks : Bledstop, Metherinal, Methylergometrine, Methylergometrine Maleate, Methiagin, Methylate, Metvell, Morgin, Myotonic, Myomergin, Pospargin, Utergin, and Viatrin.

What is M -ethylergometrine

class	Ergot alkaloids
Category	Prescription drug
Benefit	Coping with postpartum bleeding or bleeding after a miscarriage
Used by	Mature
Methylergometrine for pregnant and lactating women	Category C: Animal studies have shown an adverse effect on the fetus, but there have been no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus. Methylergometrine is absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.
Drug form	Tablets and injections

Warning Before Using Methylergometrine

Methylergometrine should not be used carelessly and must be used according to a doctor 's prescription . Some things to consider before using this drug include:

Do not use methylergometrine if you are allergic to it or to other ergot alkaloid medicines, such as ergonovine.
Tell your doctor if you have had hypertension, preeclampsia or eclampsia in this or a previous pregnancy . Methylergometrine should not be used in patients with these conditions.
Tell your doctor if you have or have had kidney disease, liver disease, coronary heart disease, diabetes, chest pain ( angina pectoris ), high cholesterol, diabetes, heart valve disease , or peripheral artery disease , such as Raynaud's syndrome .
Do not consume alcoholic beverages while on treatment with methylergometrine.
Do not do activities that require alertness, such as driving a vehicle or operating heavy machinery, after using methylergometrine, because this drug can cause dizziness.
Tell your doctor that you are using methylergometrine if you are planning to have surgery under general anesthesia , including dental surgery.
Tell your doctor if you are taking other medications, including supplements and herbal products, to avoid drug interactions.
Immediately consult a doctor if a drug allergic reaction appears after using m

Dosage and Rules for Use Methylergometrine

The dosage of methylergometrine will be adjusted according to the form of the drug and the patient's condition. The following are methylergometrine dosages for adults grouped by condition:

Postpartum bleeding

Initial dose of 0.2 mg, given by infusion or injection into the muscle in the last phase of labor or after delivery. Doses can be repeated every 2–4 hours for a maximum of 5 times.

Entering the puerperium or after delivery of the placenta, treatment is continued with 0.2 mg methylergometrin tablets, consumed 3–4 times a day, for 2–7 days.

Bleeding after miscarriage

The dose of methylergometrine to treat bleeding after miscarriage is the same as the dose given postpartum. However, in cases of miscarriage, drug administration is done after all the fetal tissue has come out.

How to Use Methylergometrine Properly

Injectable methylergometrine should only be given by a doctor or medical officer under the supervision of a doctor. The doctor will inject methylergometrine into a vein or into a muscle, depending on the patient's condition.

If you are prescribed methylergometrine tablets, follow your doctor's advice and read the information on the drug packaging before taking them. Do not increase or decrease your dose without consulting your doctor first.

Take methylergometrine tablets at the same time every day for maximum treatment effect. If you forget to take it, consume it immediately if it is not yet close to the schedule for taking the next drug. If it is close, ignore the missed dose and do not double the dose at a later time.

Methylergometrine tablets can be taken with or without food. However, do not consume grapefruit , or food and drinks that contain the fruit while taking methylergometrine, because it can increase the risk of side effects.

Store methylergometrine tablets in a cool place protected from direct sunlight, and keep out of reach of children.

Methylergometrine Interactions with Other Drugs

Interaction effects that can occur if methylergometrine is used with certain drugs include:

Increased risk of ergot poisoning when used with CYP3A4 inhibitors, such as erythromycin , clarithromycin, ritonavir, ketoconazole , itraconazole, or amiodarone
Increases the risk of narrowing of the arteries when used with beta-blocker antihypertensive drugs, such as atenolol , bisoprolol, or propranolol
Reduces the effectiveness of methylergometrine when used concomitantly with anesthetic drugs
Decreased effectiveness of nitroglycerin and other antianginal drugs, such as ranolazine and isosorbide dinitrate

Methylergometrine Side Effects and Dangers

Some of the side effects that may arise after using methylergometrine are:

Nausea or vomiting
Bad taste in mouth
Stomach ache
Diarrhea
Headache
Dizzy

Consult a doctor if the side effects above do not subside or get worse. Immediately see a doctor if an allergic drug reaction or more serious side effects occur, such as: