Mixalgin is useful for relieving severe pain due to disorders of the nerves (neuralgia), including those caused by neuritis (inflammation of nerve cells) . This drug can also help reduce fever and relieve pain due to migraines, surgical procedures, digestive tract disorders, or cancer .

Each Mixalgin caplet contains the active ingredient metamizole sodium 500 mg, as well as additional ingredients consisting of 50 mg vitamin B1 (thiamine nitrate), 10 mg vitamin B6 (pyridoxine HCl), 10 mg vitamin B12 (cyanocobalamin), and 50 mg caffeine . This medicine can only be purchased with a doctor's prescription.

The metamizole content in Mixalgin has an anti-pain effect as well as an anti-fever ( analgesic-antipyretic ). This drug works by inhibiting prostaglandins which cause pain and inflammation. Metamizole is also able to stimulate the production of endorphins in the body which act as a natural pain reliever.

Vitamins B1, B6, and B12 contained in Mixalgin are useful for maintaining healthy nerves and repairing damaged nerve cells that trigger pain. Meanwhile, the caffeine in this drug is useful for increasing the effectiveness of metamizole in reducing pain.     

What is Mixalgin

class Analgesic-antipyretic
Active ingredients Metamizole sodium, thiamine nitrate ( vitamin B1 ), pyridoxine HCl ( vitamin B6 ), cyanocobalamin ( vitamin B12 ), and caffeine.
Category Prescription drug
Benefit Relieves pain and reduces fever
Consumed by Mature
Metamizole in Mixalgin for pregnant and lactating women Category N : Not yet categorized.

The metamizole contained in Mixalgin should not be used during pregnancy or breastfeeding, because the contents of this drug have the risk of causing dangerous blood disorders.

Drug form Film-coated caplets

Precautions Before Taking Mixalgin

Mixalgin should not be consumed carelessly. Some things to consider before using this drug include:

  • Do not take Mixalgin if you are allergic to the active ingredients contained in this drug. Always tell your doctor about any allergies you have.
  • Tell your doctor if you have porphyria , liver failure, kidney failure, low blood pressure (hypotension), or a blood disorder (such as aplastic anemia , agranulocytosis , or leukopenia ). The metamizole in Mixalgin should not be used in people with this condition.
  • Tell your doctor if you have or have ever had muscle weakness, heart disease, dehydration, asthma, liver disease, kidney disease, stomach ulcer , or duodenal ulcer .
  • Do not immediately drive a vehicle or operate heavy machinery after taking Mixalgin, because the metamizole content in this drug can reduce your concentration during activities.
  • Do not consume alcoholic beverages while undergoing treatment with Mixalgin because it can cause side effects.
  • Tell your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.
  • Tell your doctor if you are taking other medicines, including herbal medicines and supplements, to prevent drug interactions.
  • Immediately consult a doctor if you experience a drug allergic reaction or overdose after taking Mixalgin.

Dosage and Rules for Use Mixalgin

The usual dose of Mixalgin to relieve pain and reduce fever is 1 caplet, 3 times a day. Maximum dose is 4 caplets a day.

How to Take Mixalgin Properly

Follow the doctor's recommendations and read the information on the Mixalgin packaging before starting to consume it. Do not increase your dose without consulting your doctor.

Take Mixalgin with food or while eating. Swallow the Mixalgin caplet with plain water.

Store Mixalgin in a cool place and avoid direct sunlight. Keep medicine out of reach of children.

Mixalgin Interactions with Other Drugs

Drug interactions that can occur if the metamizole content in Mixalgin is used together with certain drugs include:

  • Increased risk of developing thrombocytopenia which causes easy bruising and bleeding when used with anticoagulant drugs
  • Increased risk of severe hypothermia when used with chlorpromazine
  • Increased risk of side effects or metamizole poisoning when used with tricyclic antidepressants, birth control pills , allopurinol , or MAOI drugs ( monoamine oxidase inhibitors )
  • Increased risk of side effects of antidiabetic drugs, sulfonamide antibiotics , or phenytoin
  • Increased risk of side effects of the drug methotrexate in the form of blood disorders
  • Decreased effectiveness of metamizole in Mixalgin if taken with barbiturate , glutethimide, or phenylbutazone drugs
  • Decreased effectiveness of the drug ciclosporin

Side Effects and Dangers of Mixalgin

Considering that Mixalgin contains metamizole, side effects that may arise after taking this drug are:

  • Nausea, vomiting, stomach pain, ulcer
  • Dizziness or spinning sensation ( vertigo )
  • Low blood pressure ( hypotension ) which can be characterized by dizziness, body feeling weak or unstable, difficulty concentrating, and blurred vision

Check with your doctor if the side effects mentioned above do not improve or get worse. Immediately consult a doctor if you experience an allergic drug reaction, or the following serious side effects occur:

  • Chest pain
  • Heart beating too fast, too slow, or irregularly ( arrhythmia )
  • Eyes and skin look yellow ( jaundice )
  • Symptoms of kidney problems, such as pain when urinating, anuria or infrequent urination, small amounts of urine, or bloody urine
  • Symptoms of infection, which are characterized by fever, chills, rashes on the skin, muscle weakness, palpitations, or fast breathing
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