Pancuronium is a medication used to relax muscles during endotracheal intubation procedures or during surgery. Pancuronium belongs to the class of non-depolarizing muscle relaxants which work by inhibiting motor nerve stimulation signals to the muscles.

Pancuronium is used in the process of anesthesia or anaesthesia. This drug will be given intravenously or through a vein. This medicine will be injected by a doctor or by medical personnel under the supervision of a doctor.

Pancuronium trademark : Pavulon

What is Pancuronium?

class Neuromuscular blocking drugs (NMBDs) or nondepolarizing muscle relaxants
Category Prescription drug
Benefit Relaxes muscles during endotracheal intubation or during surgery
Used by Adults and children
Pancuronium for pregnant and lactating women Category C : Animal studies have shown an adverse effect on the fetus, but there have been no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Pancuronium is not known to be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug form Inject

Warnings Before Using Pancuronium:

  • Do not use pancuronium if you have a history of allergy to this drug.
  • Do not use pancururonium with other muscle relaxants, such as suxamethonium .
  • Tell your doctor if you have liver disease, kidney disease, disorders of the respiratory tract and lungs, heart disease , hypertension, nerve and muscle (neuromuscular) disorders, including muscular dystrophy, myasthenia gravis , or polio .
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • Tell your doctor if you are taking any other medicines, including herbal medicines and supplements.
  • Tell your doctor if you are planning surgery, including dental surgery.
  • Immediately see a doctor if you experience an allergic drug reaction or overdose after using this drug.

Dosage and Rules for Using Pancuronium

Pancuronium is given by injection into a vein (intravenously) by a doctor or medical officer under the supervision of a doctor. Below is the distribution of pancuronium doses based on their intended use:

As part of an anesthetic procedure  

  • Adult: 0.04–0.1 mg/kgBB.
    Maintenance dose: 0.015–0.1 mg/kgBB
  • Children aged <30 days: 0.02 mg/kgBW
    Maintenance dose: 0.05–0.1 mg/kgBW
  • Children >30 days old: 0.04–0.1 mg/kgBW
    Maintenance dose: 0.015–0.1 mg/kgBW

Endotracheal intubation procedure

  • Adult: 0.06–0.1 mg/kgBB
  • Children aged <30 days: 0.06–0.1 mg/kg

Intensive care for patients on ventilators

  • Adult: 0.06 mg/kg, every 1–1½ hours

How to Use Pancuronium Properly

Pancuronium is used by injection into a vein (intravenously) or also by infusion. Therefore, this drug should only be given by a doctor or medical worker under the supervision of a doctor.

Do not try to use pancuronium without a doctor's supervision. This will endanger lives.

This medicine should be stored at room temperature. Avoid exposure to direct sunlight and keep out of reach of children.

Pancuronium Interactions with Other Drugs

There are several interactions that can occur when pancuronium is used with other medicines, including:

  • Increased effectiveness of pancuronium and the risk of side effects when used with aminoglycoside class antibiotics, polypeptide class antibiotics , fentanyl, amphotericin B , quinine, or other muscle relaxant drugs, such as suxamethonium
  • Increased risk of a more prolonged effect of pancuronium when used with colistimethate or other inhaled anesthetics, such as halothane and enflurane
  • Increased risk of side effects, such as muscle weakness, paralysis, and difficulty breathing, when used with abobotulinumtoxinA, incobotulinumtoxin A, onabotulinumtoxinA, or prabotulinumtoxinA
  • Changes in the effects of pancuronium and increased risk of developing myopathy when used with corticosteroid drugs
  • Decreased effectiveness of pancuronium when used with neostigmine, theophylline or azathioprine

Pancuronium Side Effects and Dangers

Some side effects that can appear after using pancuronium are:

  • Increased blood pressure to hypertension
  • Increased heart rate ( tachycardia )
  • Narrowing of the bronchial tubes (bronchospasm)
  • Increased production and secretion of saliva
  • Pain or sores at the injection site

In some cases, the use of pancuronium can also cause a drop in blood pressure (hypotension) and bradycardia .

Immediately see a doctor if the complaints or side effects mentioned above appear or you experience an allergic drug reaction which is characterized by the appearance of an itchy rash on the skin, swelling of the eyelids and lips, or difficulty breathing.

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