Pantoprazole is a drug to relieve symptoms due to increased stomach acid, such as a burning feeling in the chest, increased stomach acid, or difficulty swallowing. This drug is commonly used in people with  gastroesophageal reflux disease (GERD), erosive esophagitis, stomach ulcers, or Zollinger-Ellison syndrome. 

Pantoprazole works by reducing the production of stomach acid. This way of working helps the process of healing stomach or esophageal tissue damaged by excessive stomach acid.

Trademarks of pantoprazole:  Ciprazole , Erprazole , Fiopraz Fastzol , Pantera 20, Pantomex, Pantopump, Pepzol 20, Pantomet, Pantopump 40, Pantozol 40, Pantozol IV, Pepzol, Pantocapri, Pantoprazole, Pantoprazole Sodium, Pantoprazole Sodium Sesquihydrate, Prazopump, Panvell , Propanzole, Panloc, Pranza, Topazol, Ulcan, Vomizole

What is Pantoprazole

class Prescription drug
Category Proton pump inhibitor
Benefit Reduces stomach acid production
Used by Adults, seniors and children
Pantoprazole for pregnant and lactating women Category C:  Animal studies have shown an adverse effect on the fetus, but there have been no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Pantoprazole can be absorbed into breast milk. Therefore, consult your doctor about the benefits and risks of using pantoprazole while breastfeeding.

Drug form Tablets, caplets and injectable fluids

 Warning Before Using Pantoprazole

Pantoprazole should not be used carelessly. Before using this drug, you need to pay attention to the following points:

  • Do not use pantoprazole if you are allergic to it or to other proton pump inhibitors, such as lansoprazole .
  • Tell your doctor if you are taking other medications, including supplements and herbal products, to prevent drug interactions.
  • Tell your doctor if you have or currently have kidney disease, liver disease , electrolyte disturbances, autoimmune disease, osteoporosis,  hypoparathyroidism  , vitamin B12 deficiency, diarrhea, or  seizures .
  • Consult with your doctor regarding the use of pantoprazole in the elderly.
  • Do not give pantoprazole to children under 5 years of age.
  • Tell your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.
  • Tell your doctor that you are using pantoprazole if you are planning to have an endoscopy or any other medical procedure.
  • Immediately consult a doctor if you experience an allergic drug reaction or overdose after using pantoprazole.

Dosage and Rules for Using Pantoprazole

The doctor will determine the dosage and duration of treatment according to the condition and age of the patient. Pantoprazole can be given in the form of oral medication, infusion, or injection into a vein (intravenous/IV). Here is the explanation:

Drug form

Condition: gastroesophageal reflux disease ( GERD )

  • Adult: 20–40 mg once daily for 4 weeks. If necessary, treatment can be extended to 8 weeks. Maintenance dose 20–40 mg per day.
  • Children 5 years of age, 15–40 kg body weight: 20 mg once daily for up to 8 weeks.
  • Children over 5 years weighing >40 kg: 40 mg once daily for up to 8 weeks.

Condition: prevention of stomach ulcers due to consumption of NSAID class drugs

  • Adult: 20 mg, once a day.

Condition: gastric ulcer or duodenal ulcer

  • Adult: 40 mg, once a day. If necessary, the dose can be increased up to 80 mg. If the patient has a duodenal ulcer, treatment is continued for 2–4 weeks. As for stomach ulcers, the duration of treatment is 4–8 weeks.

Condition: Zollinger-Ellison syndrome

  • Adult: 40 mg, 2 times a day. If necessary, the dose may be increased up to 240 mg per day. If the daily dose is more than 80 mg, the dose should be divided into 2 consumption schedules.

Condition:  Helicobacter pylori infection

  • Adult: 40 mg twice daily for 7 days. This treatment is combined with the antibiotics clarithromycin, amoxicillin, or metronidazole.

Syringe form

Conditions: gastroesophageal reflux disease (GERD) and stomach ulcers

  • Adult: 40 mg daily by slow IV injection or short-term infusion over 2–15 minutes.

Condition: Zollinger-Ellison syndrome

  • Adult: 80 mg 1–2 times daily by slow IV injection or short-term infusion over 2–15 minutes.

How to use Pantoprazole correctly

Injectable pantoprazole should only be given by a doctor or medical officer under the supervision of a doctor. However, usually taking pantoprazole with oral medication is preferred.

If you are prescribed pantoprazole to drink by your doctor, follow the doctor's recommendations and read the information printed on the drug packaging before using this drug. Use pantoprazole according to the recommended dosage and do not increase or decrease the prescribed dose.

Pantoprazole in tablet form can be taken before or after meals. Take pantoprazole tablets with a glass of water without crushing, chewing or splitting them first.

If you are also taking sucralfate, take pantoprazole at least 30 minutes before sucralfate.

Try to take pantoprazole at the same time every day and make sure there is sufficient time between one dose and the next, so that the effect is maximized.

If you forget to take pantoprazole, do it immediately if the break with the next consumption schedule is not too close. If it is close, ignore the missed dose and do not double the dose.

Store pantoprazole in a dry place away from direct sunlight, and keep out of reach of children.

Pantoprazole Interactions with Other Drugs

Inter-drug interactions that can occur if pantoprazole is used together with other drugs are:

  • Decreased effectiveness of rilpivirine or atazanavir
  • Increased risk of side effects of digoxin on the heart
  • Increased risk of decreased magnesium levels in the blood ( hypomagnesemia ) when used with diuretic drugs
  • Increased risk of bruising and bleeding when used with  warfarin 
  • Increased risk of side effects from methotrexate
  • Decreased effect of clopidogrel drug therapy
  • Decreased absorption and effectiveness of ketoconazole or itraconazole to treat fungal infections

Side Effects and Dangers of Pantoprazole

Side effects that may appear after using pantoprazole include:

  • Headache or dizziness
  • Bloated
  • Nausea or vomiting
  • Stomach ache
  • Joint pain
  • Diarrhea
  • Fever, rash, or runny nose (usually in children)
  • Swelling at the injection site

Check with your doctor if the side effects above don't go away. Immediately see a doctor if an allergic drug reaction or more serious side effects occur, such as:

  • Severe stomach pain and diarrhea that doesn't go away or is accompanied by blood
  • Hypomagnesemia, which can be marked by dizziness, tremors , fast or irregular heartbeats ( arrhythmias ), muscle cramps, and stiffness in the hands or feet
  • New lupus symptoms  or worsening of pre-existing lupus symptoms, such as a rash on the nose and cheeks or joint pain
  • Kidney problems, which can be marked by nausea, loss of appetite, difficulty urinating, bloody urine, swelling in the legs, and weight gain

Long-term use of pantoprazole can increase the risk of developing stomach polyps or a lack of vitamin B12. Follow the doctor's recommendations and carry out routine controls to the doctor while using pantoprazole, so that side effects that may occur can be monitored.

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