Papaverine is a drug to relax the smooth muscles that make blood vessels dilate. That way, blood pressure will drop and blood will flow more easily.

Papaverine is able to relax smooth muscles. In addition to being able to lower blood pressure, this drug can also overcome various spasm conditions in the smooth muscles. Some of the conditions that can be treated by this medicine are heart attack, chest pain, stomach cramps, and gallbladder disorders. Keep in mind that this drug cannot be used to treat erectile dysfunction.

Papaverine trademarks: Papaverine HCL, Gastromag, Spasmal

What Is Papaverine

Group Prescription drugs
Category Antispasmodic
Benefits Relaxes smooth muscles
Used by Adults
Papaverine for pregnant and lactating women Category C: Studies on experimental animals show side effects on the fetus, but there are no controlled studies on pregnant women. Medicines can only be used if the magnitude of the expected benefit exceeds the magnitude of the risk to the fetus.

Papavarine is not yet known to be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without first consulting your doctor.

Drug form Tablets and injections

Warnings Before Using Papaverine

Papaverine can only be used according to a doctor's prescription. Here are some things you need to pay attention to before using papaverine:

  • Do not use papaverine if you are allergic to this medicine. Always tell your doctor about any allergies you have.
  • Do not use papaverine if you suffer from priapism or a serious heart rhythm disorder, such as AV block.
  • Tell your doctor if you suffer from heart disease , high blood pressure, glaucoma , or liver disease.
  • Do not consume alcoholic beverages while you are undergoing treatment with papaverine, as it will increase the risk of side effects.
  • Do not drive or operate equipment that requires alertness during treatment with papaverine, as this drug can cause dizziness or drowsiness.
  • Tell your doctor if you are using other medicines, including herbal medicines and supplements.
  • Tell your doctor if you are pregnant, breastfeeding, or planning to become pregnant.
  • See a doctor immediately if an allergic drug reaction, serious side effect, or overdose occurs after using papaverine.

Dosage and Administration of Papaverine

The general dose of papaverine in tablet preparation is 100–300 mg 3–5 times a day.

Papavarine is also available in injectable form. Papaverine injection can be done through a vein (intravenous/IV) or through a muscle (intramuscular/IM), by a doctor or medical staff under the supervision of a doctor.

How to Use Papaverine Correctly

Follow your doctor 's advice and read the instructions on the package before using papavarine. Injectable papavarine can only be given directly by a doctor or medical personnel under the supervision of a doctor.

If you consume papavarine tablets, do not crush, chew, or split this medicine, because it can affect the effectiveness of the medicine.

If you forget to take papavarine, take it as soon as you remember. However, when it is almost time for the next dose, ignore the missed dose. Do not double the dose of papavarine to make up for a missed dose, unless directed by a doctor.

Store papavarine at room temperature, away from direct sunlight, and out of reach of children.

Interactions of Papaverine with Other Drugs

The following are a number of interaction effects that can occur if papaverine is used with other drugs:

  • Decreased effectiveness of levodopa drugs
  • Increased risk of dizziness and fainting if used with alprostadil or phentolamine
  • Increased risk of bleeding if used with anticoagulants , such as warfarin
  • Increased risk of central nervous system disorders if used with morphine

Side Effects and Dangers of Papavarine

Some side effects that may occur after using papavarine are:

  • Dizziness, headache, or spinning sensation
  • Constipation or diarrhea
  • Not feeling well
  • Unusual sleepiness _
  • Feeling sultry and hot
  • Feeling nervous

Check yourself with a doctor if the complaints above do not subside. See a doctor immediately if you experience an allergic reaction to the drug or experience more serious side effects, such as:

  • Bruising or bleeding at the injection site
  • Swelling in the injection area
  • Irregular heart rhythm ( arrhythmia )
  • Jaundice
  • Very severe headache
  • Visual impairment
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