Parnaparin is an anticoagulant drug used to prevent and treat thrombophlebitis , including deep vein thrombosis . This drug is one of the types of low molecular weight heparin (LMWH) that has an antithrombotic effect.

Parnaparin can prevent postoperative deep vein thrombosis (DVT) and overcome other thromboembolic diseases or disorders. Parnaparin should be given by subcutaneous injection (through the layer under the skin) and should not be done intramuscularly (directly into the muscle).

Parnaparin is available as an injection that can only be given by a doctor. During the use of parnaparin, it is necessary to perform a complete blood test periodically.

Parnaparin trademark: Fluxum

What is Parnaparin?

Group Anticoagulants
Category Prescription drugs
Benefits Preventing postoperative deep vein thrombosis and overcoming thromboembolic disorders or diseases
Used by Adults
Parnaparin for pregnant and lactating women Category C : Studies on experimental animals have shown side effects on the fetus, but there have been no controlled studies on pregnant women. Medicines can only be used if the magnitude of the expected benefit exceeds the magnitude of the risk to the fetus.

It is not known whether Parnaparin is absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without first consulting your doctor.

Drug form Injection

Warnings Before Using Parnaparin:

  • Do not use parnaparin if you have a history of allergy to this drug.
  • Do not use parnaparin if you have a history of thrombocytopenia after using heparin, acute bacterial endocarditis , hemorrhagic stroke, and other conditions or diseases that are at risk of causing bleeding.
  • Tell your doctor if you are pregnant, breastfeeding, or planning to become pregnant.
  • Tell your doctor if you have a history of kidney disease, liver disease, obesity, hypertension , and other conditions or diseases that are at risk of causing bleeding.
  • Tell your doctor if you have ever had brain or spinal cord surgery, spinal anesthesia or analgesia, therapy with antivitamin K, or received a prosthetic heart valve.
  • Avoid consuming alcoholic beverages while using parnaparin because it can increase the risk of bleeding.
  • Avoid smoking while using parnaparin because it can reduce the effectiveness of the drug.
  • Tell your doctor if you are taking other medicines, including herbal medicines and supplements.
  • See a doctor immediately if an allergic drug reaction or overdose occurs after consuming parnaparin.

Parnaparin Dosage and Administration

Parnaparin can only be given to adults, with the note that the use in elderly patients needs to be more careful. The dose of parnaparin will be determined by the doctor according to the patient's condition.

Here is the recommended dosage breakdown:

Condition: Postoperative deep vein thrombosis (DVT) prophylaxis

  • General surgery: 3,200 IU 2 hours before surgery, continued for 7 days or until the patient fully recovers
  • Orthopedic or high-risk surgery: 4,250 IU mL 12 hours before and 12 hours after surgery, continued for 10 days

Condition: Thromboembolic disorders

  • Dose : 6,400 IU for 7–10 days

How to Use Parnaparin Correctly

Follow the doctor 's recommendations in using parnaparin. Parnaparin is only available as an injection. Therefore, this medicine can only be given by a doctor or medical staff under the supervision of a doctor in a hospital.

Parnaparin should be injected subcutaneously. Injections are usually performed alternately on the fat tissue in the upper right or left buttock, or around the abdomen.

Do routine complete blood tests while using parnaparin. Generally, the inspection should be done 2 times a week for at least 1 month. After that, the frequency of inspection can be reduced.

Store parnaparin in a cool place, and keep it out of the reach of children.

Parnaparin Interactions with Other Drugs and Substances

When used with other drugs, parnaparin can cause a number of interactions, including:

  • Increased risk of side effects in the form of bleeding if used with other anticoagulant drugs, antiplatelet drugs, nonsteroidal anti-inflammatory drugs ( NSAIDs ), or fibrinolytic drugs, such as streptokinase
  • Increased risk of hyperkalemia if used with ACE inhibitor drugs
  • Decreased effectiveness of parnaparin if used together with nitroglycerin through intravenous injection

Side Effects and Dangers of Parnaparin

Some of the side effects that often arise as a result of consuming parnaparin are:

  • Bleeding
  • Low platelet count ( thrombocytopenia )
  • Tissue damage or death at the injection site
  • Hyperkalemia related to hyperaldosteronism
  • Increased transaminase enzymes

Check with a doctor if you experience side effects as mentioned above or experience a drug reaction, such as an itchy and swollen rash, swollen eyes and lips, or difficulty breathing, after using parnaparin.

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