Paromomycin is a drug to treat parasitic infections, such as amebiasis in the digestive tract. This drug can also be used as an adjunctive therapy in the treatment of hepatic encephalopathy .

Paromomycin works by stopping the growth of parasites in the intestine, so that the infection can be overcome. Meanwhile, as an additional drug for hepatic encephalopathy , paramomycin will help stop the growth of bacteria that produce ammonia.

Paromomycin trademark: Gabryl

What is Paromomycin

class Prescription drug
Category Aminoglycoside antibiotics
Benefit Treating amebiasis of the gastrointestinal tract or as an adjunct in the treatment of hepatic encephalopathy.
Consumed by Adults and children
Paromomycin for pregnant and lactating women  Category C: Animal studies have shown an adverse effect on the fetus, but there have been no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Paromomycin is not known to be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug form Tablets and syrup

Precautions Before Taking Paromomycin

Paromomycin should only be used as prescribed by a doctor. The following are some things you need to pay attention to before taking paromomycin:

  • Tell your doctor about any history of allergies you have. Paramomycin should not be given to patients who are allergic to it or to other aminoglycoside antibiotics, such as gentamicin .
  • Tell your doctor if you have or currently have kidney disease or digestive disorders, such as intestinal obstruction or ulcerative colitis .
  • Tell your doctor if you are taking certain medications, supplements or herbal products.
  • Consult your doctor if you plan to be vaccinated with live vaccines while on paromomycin.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • See a doctor immediately if you have an allergic drug reaction , serious side effects, or an overdose after taking paromomycin.

Dosage and Rules for Use of Paromomycin

The dose of paromomycin varies for each patient. The doctor will determine the dosage according to the condition and response of the patient's body. The following is the dose of paromomycin for children and adults divided according to the condition to be treated:

  • Conditions: Amebiasis of the digestive tract. The
    dose is 20–25 mg/kg, 3 times a day for 5–10 days.
  • Condition: Adjunctive therapy for hepatic encephalopathy The dose is 4,000 mg in divided doses for 5–6 days.
  • Conditions: Dientamoeba fragilis
    infection . The dose is 25–30 mg/kg, 3 times a day for 7 days.
  • Conditions: Worm infections, such as T. saginata or T. solium.
    The dose is 11 mg/kg, divided into 4 doses.

How to Take Paromomycin Properly

Take paromomycin according to doctor's instructions and instructions on the drug packaging. Do not change the dosage without consulting your doctor first .

Paromomycin should be taken after food. Do not stop treatment with paromomycin even if you feel better, except on doctor's advice.

If you forget to take paromomycin, take it immediately if it is not near the time for the next dose. If it's close, ignore the missed dose. Do not double the dose of paromomycin to make up for a missed dose.

Store paromomycin at room temperature and place it in a closed container. Avoid exposure to direct sunlight and keep out of reach of children.

Interactions of Paromomycin with Other Drugs

The following are a number of interaction effects that can occur if paromomycin is taken with other drugs:

  • Decreased effectiveness of live vaccines, such as the BCG vaccine or typhoid vaccine
  • Increased effects of tubocurarine, atracurium, or doxacurium, so that it can increase the risk of respiratory problems

Side Effects and Dangers of Paromomycin

Some of the side effects that can occur after consuming paromomycin are:

  • Diarrhea
  • Nausea or vomiting
  • Abdominal pain or stomach cramps
  • Loss of appetite
  • Hot and burning feeling in the chest ( heartburn )

Check with your doctor if the complaints mentioned above do not go away or get worse. Immediately see a doctor if you experience an allergic drug reaction or experience more serious side effects, such as:

  • Sudden ringing in the ears or deafness
  • Severe dizziness or headache
  • Oily stools
  • seizures
  • Numbness or tingling
  • Unusual muscle pain , fatigue, and weakness

In addition, long-term use of paromomycin can increase the risk of developing fungal infections, such as candidiasis .

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