Penicillin G Procaine

Penicillin G procaine or procaine benzylpenicillin is an antibiotic drug for treating bacterial infections, such as anthrax, syphilis, or group A beta-hemolytic Streptococcus infection , or Staphylococcus infection .

Penicillin G procaine works by inhibiting the formation of the bacterial cell wall that causes infection. Keep in mind, this drug cannot be an infection caused by a virus, such as the flu. This drug is available in injection form and should only be given according to a doctor's prescription.

Penicillin G procaine trademarks: Benzathine Benzylpenicillin, Procaine Benzyl Penicillin, Procaine Penicillin G Meiji

What is Penicillin G Procaine

class	Prescription drug
Category	Penicillin antibiotics
Benefit	Treat anthrax, syphilis, group A beta-hemolytic Streptococcus infections, or Staphylococcus infections
Used by	Adults and children
Penicillin G procaine for pregnant and lactating women	Category B: Animal studies have not demonstrated a risk to the fetus, but there are no controlled studies in pregnant women. Penicillin G procaine can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.
Drug form	Inject

Precautions Before Using Penicillin G Procaine

There are several things that you should pay attention to before using penicillin G procaine, including:

Tell your doctor about any history of allergies you have. Penicillin G procaine should not be given to patients who are allergic to this drug or other penicillin class drugs.
Tell your doctor if you have or currently have asthma, heart disease, kidney disease, blood disorders, colitis, or Brugada syndrome .
Tell your doctor if you plan to get vaccinated with live vaccines while using penicillin G procaine, because this medication may reduce the effectiveness of the vaccine being used.
Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
Tell your doctor if you are taking any other medicines, including herbal medicines and supplements.
Immediately consult a doctor if you have an allergic drug reaction, serious side effects, or overdose after using penicillin G procaine.

Dosage and Rules for Using Penicillin G Procaine

Penicillin G procaine will be injected by a doctor or medical officer under the supervision of a doctor by injection into the muscle (intramuscular/IM).

The dose of the drug given depends on the condition you want to treat and the age of the patient. Here is the explanation:

Condition: Syphilis

Adult: Dose for early-stage syphilis 600 mg once daily for 10 days. Dosage for advanced conditions 600 mg, once daily, for 17 days.

Condition: Neurosyphilis

Adult: The dose with probenecid in combination is 1800–2400 mg once daily for 17 days.

Condition: Congenital syphilis

Children ≤2 years: 50 mg/kg once daily for 10 days.

Condition: Cutaneous anthrax

Adults: 600–1,000 mg, once daily.

Condition: Treatment and prevention of anthrax

Adult: 200 mg, every 12 hours, for 60 days.
Children: 25 mg/kg, every 12 hours, for 60 days.

Condition: Group A beta-hemolytic Streptococcus infection , Staphylococcus infection

Adult: 1,500 mg per day, for 2–5 days. The 4th and 5th doses will be given according to the needs and severity of the disease.

How to Use Penicillin G Procaine Correctly

Penicillin G procaine will be injected directly by a doctor or medical staff under the supervision of a doctor.

Follow the drug injection schedule given by the doctor. Do not stop taking medication without consulting your doctor first. Follow all the recommendations and suggestions given by the doctor while undergoing treatment with penicillin G procaine so that the effectiveness of the treatment is maximized.

If you are using penicillin G procaine long-term, you may be asked to have regular blood tests. Make sure you attend the inspection on schedule.

Interactions of Penicillin G Procaine with Other Drugs

The following are a number of interaction effects that can occur when penicillin G procaine is used with other drugs:

Increased levels of methotrexate in the blood which can cause side effects, such as vomiting, mouth sores, and decreased blood cell levels
Decreased levels of penicillin G procaine when used with tetracycline or doxycycline
Increased risk of methemoglobinemia when used with prilocaine
Decreased effectiveness of live vaccines, such as the BCG vaccine or cholera vaccine
Increased risk of bleeding when used with blood thinners, such as warfarin
Decreased effectiveness of birth control pills