Perampanel is a drug to treat and prevent seizures in epilepsy patients. Perampanel can be used as a single therapy or in combination with other drugs. This medicine should only be used with a doctor's prescription.

Perampanel works by inhibiting glutamate, which is a natural chemical that functions to stimulate the flow of electrical impulses in the brain. The workings of perampanel will reduce excessive electrical activity in the brain so that seizures can stop or be prevented.

It should be noted that perampanel cannot cure epilepsy , but only prevents and controls seizures. Therefore, this drug needs to be consumed regularly in the long term.

Perampanel trademark: Fycompa

What is Pannel

class Prescription drug
Category Anticonvulsant
Benefit Treating and preventing seizures in epilepsy
Used by Adults and children
Perampanel for pregnant and lactating women Category C: Animal studies have shown an adverse effect on the fetus, but there have been no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

It is not yet known whether perampanel can be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug form Tablet

Warning Before Consuming Perampanel

There are several things that you should pay attention to before consuming perampanel, namely:

  • Do not use perampanel if you have an allergy to this drug. Tell your doctor about any allergies you have.
  • Tell your doctor if you have or are suffering from liver disease , balance problems, difficulty walking, galactose intolerance, kidney disease, or are undergoing routine dialysis procedures .
  • Tell your doctor if you have or are suffering from a mental disorder, such as depression , or have thoughts of suicide or self-harm.
  • Tell your doctor if you have or are suffering from alcohol addiction or drug abuse .
  • Avoid consuming alcoholic beverages while undergoing treatment with perampanel because it can increase the risk of side effects.
  • Do not drive or do activities that require alertness if this drug causes dizziness, drowsiness, or blurred vision.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • Consult with your doctor about the most effective contraceptives to prevent pregnancy while you are having treatment with perampanel. If you are currently using birth control pills, consult your doctor about additional or alternative contraceptive methods .
  • Tell your doctor if you are taking certain drugs, supplements or herbal products, to anticipate drug interactions.
  • Immediately see a doctor if you experience serious side effects or allergic reactions to drugs after using perampanel.

Dosage and Rules for Use Perampanel

The following is the perampanel dosage for treating seizures and epilepsy in adults and children over 4 years of age:

  • Initial dose: 2–4 mg once daily, at bedtime. The dose may be increased by 2 mg daily every 1 or 2 weeks, depending on the patient's condition and response to treatment.
  • Maintenance dose: 4–8 mg per day.
  • Maximum dose: 12 mg per day.

How to Consume Perpanel Properly

Always follow the doctor 's recommendations and read the information on the drug packaging before taking perampanel.

Perampanel can be consumed before or after meals. Swallow the perampanel tablet whole with the help of a glass of water. Do not split, chew, or crush the medication.

Consume perampanel at the same time every day. If you forget to take perampanel, consume this drug immediately if it is not near the next schedule. If it is close, ignore the missed dose and do not double the next dose.

Perampanel can cause drug dependence. Do not increase your perampanel dose without consulting your doctor first, because there is a risk of overdose and death.

Don't stop perampanel without consulting a doctor first even though you don't feel any complaints or you haven't had a seizure in a long time. Abruptly stopping the drug may cause the seizures to worsen or recur.

Check with your doctor regularly during treatment with perampanel to monitor your condition and response to treatment.

Store perampanel at room temperature, away from direct sunlight, hot temperatures, and damp conditions. Keep medicine out of reach of children.

Perampanel Interaction with Other Drugs

The use of perampanel together with other drugs can cause several interaction effects, including:

  • Decreased effectiveness of perampanel when used with certain anticonvulsant drugs, such as carbamazepine , oxcarbazepine, or phenytoin , so that the dose of perampanel needs to be increased
  • Decreased effectiveness of birth control pills
  • Perampanel decreased effectiveness when used with rifampicin
  • Increased risk of side effects from drugs that depress the central nervous system, such as benzodiazepines , opioid analgesics, barbiturates , or antihistamines

Perampanel Side Effects and Dangers

Some of the side effects that may occur after consuming perampanel are:

  • Headache
  • Dizzy
  • Drowsiness
  • Fatigue
  • Easily offended
  • Nauseous
  • Vomit
  • Stomach ache
  • bruises
  • Weight gain

Check with your doctor if these side effects don't go away or get worse. See a doctor immediately if you experience an allergic drug reaction or serious side effects, such as:

  • vertigo
  • Severe dizziness as if you were about to faint
  • Difficulty walking or loss of balance
  • Loss of body coordination
  • Difficulty remembering, confusion, or hallucinations
  • Double or blurry vision
  • Frequent falls, usually experienced by the elderly

Although rare, perampanel can cause serious side effects in the form of symptoms of mental disorders in some people. See a doctor immediately if you experience:

  • Depression
  • Drastic changes in behavior or mood
  • Thinking or trying to kill yourself or hurt yourself
  • Anxiety disorder
  • Panic attacks
  • Sleep disturbance or insomnia
  • Becoming more aggressive, irritable, or violent
Back to blog