Quetiapine is an antipsychotic drug that is useful for treating mental disorders, such as schizophrenia, bipolar disorder, or depression . This medicine is available in tablet form and should only be used as directed by a doctor.

Mental disorders can occur due to an imbalance of natural chemicals ( neurotransmitters ) in the brain. Quetiapine works by blocking the action of some neurotransmitters , such as serotonin and dopamine , so that brain chemicals become balanced.

Quetiapine can reduce hallucinations , improve concentration, and stabilize mood. This drug can also increase appetite, desire for activity, and sleep quality, as well as help patients think more clearly and positively.

Quetipepine trademarks : Q-Pin, Q-Pin Xr, Quetipeine Fumarate, Seroquel, or Seroquel Xr

What is Quetiamine

class Prescription drug
Category Atypical antipsychotics
Benefit Treating mental disorders, such as schizophrenia , treating and preventing bipolar disorder , and treating depression.
Consumed by Mature
Quetiapine for pregnant and lactating women Category C: Studies in experimental animals show an adverse effect on the fetus, but there are no controlled studies in pregnant women. The drug should only be used if the expected benefit outweighs the risk to the fetus.

Quetiapine can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Form Film-coated tablets, slow-release tablets

Precautions Before Taking Queitiine

Quetiapine should not be used carelessly. Pay attention to the following things before taking queitiine:

  • Do not take queitiine if you are allergic to this drug.
  • Tell your doctor if you have had or are currently suffering from cataracts, liver disease, hypertension , seizures, dyslipidemia , difficulty urinating, sleep apnea , low white blood cell levels, difficulty swallowing, thyroid disorders, intestinal obstruction , constipation, or ileus .
  • Tell your doctor if you or any member of your family has or currently has diabetes, drug abuse , alcoholism, heart failure, bradycardia , cardiac QT prolongation on the EKG, or sudden cardiac arrest .
  • Tell your doctor if you are taking other medicines, including supplements and herbal products, to anticipate drug interactions.
  • Tell your doctor if you are pregnant, may become pregnant, breastfeeding or planning a pregnancy.
  • Do not drive a vehicle or do anything that requires alertness after taking quetipepine, because this drug can make you dizzy, drowsy , or have blurred vision.
  • Do not consume alcoholic beverages while on treatment with quetipepine, because it can increase the risk of side effects.
  • Immediately consult a doctor if you experience a drug allergic reaction or serious side effects after taking queitiine.

Dosage and Rules for Use Quetipepine

The dose of quetipepine will be adjusted by the doctor based on the patient's condition and response to treatment, as well as the drugs currently being used by the patient. The following is a typical queitiine dosage for adults:

1. Condition : Schizophrenia

Form of drug: Film- coated tablets


  • Day 1: 25 mg, 2 times a day
  • Day 2: 50 mg, 2 times a day
  • Day 3: 100 mg, 2 times a day
  • Day 4: 150 mg, 2 times a day
  • Day 5 onwards, the drug dose will be adjusted according to the patient's response. Daily dosage range: 300–450 mg per day, divided into 2 doses. The maximum dose is 750 mg per day.

Drug form: Slow-release tablets

Adult: Day 1: 300 mg once daily, followed by 600 mg once daily on day 2. The next day's dose will be adjusted according to the patient's response. Typical daily dose: 600 mg, once a day. The maximum dose is 800 mg per day.

2. Condition : Acute manic phase of bipolar disorder

Form of drug: Film- coated tablets

Adult: Day 1 50 mg twice daily; 2nd day 100 mg 2 times a day; 3rd day 150 mg 2 times a day; 4th day 200 mg 2 times a day. Day 5 onwards, the drug dose will be adjusted according to the patient's response. Typical daily dose: 200–400 mg, 2 times a day. The maximum dose is 800 mg per day.

Drug form: Slow-release tablets

Adult: Day 1: 300 mg once daily, followed by 600 mg once daily on day 2. The next day's dose will be adjusted according to the patient's response. Typical daily dose: 400–800 mg, once a day.

3. Condition : The depressive phase of bipolar disorder

Form of drug: Film-coated tablets or slow-release tablets

Adult: Day 1 50 mg 1 time daily taken before bedtime; 2nd day 100 mg 1 time a day; 3rd day 200 mg 1 time a day; 4th day 300 mg 1 time a day. Day 5 onwards, the drug dose will be adjusted according to the patient's response. Typical daily dose: 300 mg. The maximum dose is 600 mg per day.

4. Conditions: Prevention of bipolar disorder in stable patients with treatment with queitiine

Form of drug : Film-coated tablets

Adults: 300–800 mg per day divided into 2 consumption schedules.

Drug form: Slow-release tablets

Adult: 300–800 mg once daily.

5. Condition : Depression (combined with antidepressant drugs)

Drug form: Slow-release tablets

Days 1 and 2 50 mg once a day, consumed before going to bed at night. Day 3 and 4 150 mg once a day. The dose on the following day will be adjusted according to the patient's response to treatment. Typical daily dose: 150–300 mg once daily.

How to Properly Take Queitiine

Follow the doctor 's recommendations and instructions while taking queitiine. Do not reduce or increase the dose consumed without consulting a doctor.

Film-coated queitiine tablets can be taken with food or without food. Slow-release queitiine tablets should be taken without food on an empty stomach.

Do not split, bite, or crush sustained-release tablets before swallowing them. Swallow the medication whole with a glass of water.

Queetiine should be taken regularly at the same time every day to maximize the performance of the drug. Keep taking this medicine even if you feel well. Do not stop taking the drug without consulting your doctor first.

Take control according to the schedule given by the doctor while you are undergoing treatment with queitiine. The goal is that your condition and response to treatment can be monitored.

If you forget to take quetipepine, consume it immediately as soon as you remember if the break with the next consumption schedule is not too close. If it is close, ignore the missed dose and do not double the next dose.

Store quetipepine at room temperature. Avoid exposure to direct sunlight and keep drugs out of reach of children.

Interactions of Quetipepine with Other Drugs

Some of the interaction effects that can occur if queitiine is used with certain drugs are:

  • Decreased effectiveness of quetiapine when used with John's wort supplements or the drugs carbamazepine , phenytoin, or rifampicin
  • Decreased effectiveness of drugs that increase dopamine levels, such as levodopa , when used with slow-release quetiapine
  • Increased risk of side effects with quetipepine when used with ketoconazole , itraconazole, verapamil, clarithromycin , or ritonavir
  • Increased risk of arrhythmias when used with methadone; antiarrhythmic drugs , such as amiodarone, procainamide , quinidine, or sotalol; other antipsychotics, such as chlorpromazine; or certain antibiotics, such as moxifloxacin or gatifloxacin

Drug interaction effects can also occur if queitiine is consumed with certain foods or drinks. If consumed with high-fat foods or grapefruit or its derivatives, queitiamine levels in the blood can increase.

Meanwhile, if queitiine is taken with alcoholic beverages, side effects such as drowsiness, dizziness, and difficulty concentrating, may increase.

Queitiine Side Effects and Dangers

Some of the side effects that can occur after taking queitiine are:

  • Dry mouth
  • Constipation
  • Drowsiness
  • Stomach ache
  • Fatigue
  • Weight gain
  • Blurred vision
  • Dizziness or feeling like floating

Call your doctor if the complaints mentioned above do not subside or get worse. Immediately see a doctor if you experience more serious side effects, such as:

  • Constipation accompanied by abdominal pain that does not improve
  • Constant nausea and vomiting
  • Restlessness or a desire to keep moving
  • Shaking ( tremors )
  • Changes in mood or mental state, such as anxiety, depression, or thoughts of suicide
  • Difficulty swallowing or loss of appetite
  • Yellowing of the skin or eyes ( jaundice )
  • Breathing stops during sleep ( sleep apnea )
  • Urination disorders
  • High blood sugar ( hyperglycemia ), which can be characterized by thirst or frequent urination
  • Elevated prolactin levels, which can be characterized by breast enlargement or sexual dysfunction in men, and menstrual cycle disturbances or outflow of milk outside of breastfeeding in women
  • Tardive dyskinesia which can be characterized by the appearance of uncontrolled movements of the face, lips, tongue, hands or feet

Get medical help right away if you have an allergic drug reaction or very serious side effects, such as:

  • Faint
  • Unbearable dizziness
  • seizures
  • An erection that is painful or lasts 4 hours or more
  • Neuroleptic malignant syndrome, which can be characterized by fever, muscle stiffness or weakness, muscle pain, tiredness, confusion, palpitations, dark urine, or a change in the amount of urine
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