Sodium Thiosulfate

Sodium Thiosulfate

Sodium thiosulfate is a drug to treat cyanide poisoning. Sodium thiosulfate is available in injectable form and can only be given based on a doctor's prescription.

Sodium thiosulfate or sodium thiosulfate works by accelerating the conversion of cyanide into non-toxic thiocyanide. Sodium thiosulfate can be used as sole therapy. However, for severe cases of poisoning, sodium thiosulfate is usually combined with sodium nitrate.  

Trademarks of sodium thiosulphate: -

What is Sodium Thiosulfate

class Prescription drug
Category Antidote
Benefit Overcome cyanide poisoning
Used by Adults and children
Sodium thiosulfate for pregnant and lactating women Category C: Studies in animal studies have shown an adverse effect on the fetus, but there have been no controlled studies in pregnant women. The drug should only be used if the expected benefit outweighs the risk to the fetus.

It is not known whether sodium thiosulfate is absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first

Drug form Inject

Warning Before Using Sodium Thiosulfate

Sodium thiosulfate should not be used carelessly. The following are some things you should pay attention to before using sodium thiosulfate:

  • Do not use sodium thiosulfate if you are allergic to this drug. Tell your doctor about any allergies you have, especially an allergy to sulfites.
  • Tell your doctor if you have or currently have swelling ( edema ) in your hands or feet, heart disease, high blood pressure , kidney disease, liver disease, or preeclampsia .
  • Inform the doctor how the cyanide poisoning occurred, including an estimate of the extent of the cyanide exposure.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • Tell your doctor if you are taking certain drugs, supplements or herbal products, to anticipate drug interactions.
  • Immediately see a doctor if you experience serious side effects or an allergic drug reaction after using sodium thiosulfate.

Dosage and Rules for Using Sodium Thiosulfate

The following is the distribution of sodium thiosulphate doses to treat cyanide poisoning based on the patient's age:

  • Adult: 500 mg, given after the patient has received sodium nitrite. If necessary, drug administration can be carried out again after 30 minutes, as much as half the initial dose.
  • Children : 4–10 mg/kg, with a maximum dose of 12,500 mg, given after the patient has received sodium nitrite. If necessary, drug administration can be carried out again after 30 minutes, as much as half the initial dose.

How to give sodium thiosulphate

Always follow your doctor 's advice before using sodium thiosulfate. This medicine is given by a doctor or medical personnel under the direct supervision of a doctor at a health facility or hospital.

Sodium thiosulfate is given by infusion into a vein. The drug is injected slowly at 2.5–5 ml per minute.

Treatment of cyanide poisoning will generally be carried out in a hospital (inpatient). While undergoing treatment using sodium thiosulfate, you will be asked to have regular blood tests to monitor your body's condition and response to treatment.

Interaction of Sodium Thiosulfate with Other Drugs

The use of sodium thiosulfate together with other drugs can cause interactions between drugs. The interaction effect that can occur if sodium thiosulfate is used together with cisplatin is a decrease in the effects of cisplatin .

Side Effects and Dangers of Sodium Thiosulfate

Side effects that may arise after using sodium thiosulphate include:

  • Stomach ache
  • Vomit
  • Headache
  • The body feels warm
  • Bad taste in mouth

Tell your doctor if these side effects don't go away or get worse. Tell your doctor or nurse right away if you have an allergic drug reaction or more serious side effects, such as:

  • Very severe dizziness
  • Faint
  • Confused
  • Unusual bruising or bleeding
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