Trandolapril is a drug to lower blood pressure in people with hypertension. Controlled blood pressure can reduce the risk of complications, such as stroke, heart attack, heart failure, or impaired kidney function.

Trandolapril belongs to the class of ACE inhibitors . This drug works by inhibiting the action of the angiotensin-converting enzyme so that the conversion of angiotensin I to angiotensin II does not occur. This way of working will make blood vessels dilate, blood flow more smoothly, blood pressure drops, and the heart's workload is reduced.

In order for treatment to be more effective and blood pressure to be better controlled, the use of trandolapril must be balanced with adopting a healthy lifestyle, such as by exercising regularly, not smoking or drinking alcoholic beverages, or limiting consumption of foods that are high in salt.

Trademark of trandolapril: Tarka

What is Trandolapril

class Prescription drug
Category Angiotensin-converting enzyme (ACE) inhibitors
Benefit Treating hypertension
Used by Mature
Trandolapril for pregnant and lactating women Category D: There is positive evidence of risk to the human fetus, but the benefits may outweigh the risks, for example in dealing with a life-threatening situation.

It is not known whether trandolapril is absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug form Tablet

Precautions Before Taking Trandolapril

Follow the doctor's recommendations and suggestions while undergoing treatment with trandolapril. Before using this drug, you need to pay attention to the following points:

  • Tell your doctor about any history of allergies you have. Trandolapril should not be taken by someone who is allergic to trandolapril and another ACE inhibitor , such as lisinopril .
  • Tell your doctor if you have or currently have angioedema , diabetes, kidney disease, liver disease, cardiomyopathy , aortic valve stenosis, scleroderma , high potassium blood level, lupus, or are on dialysis .
  • Tell your doctor if you are taking certain medications, supplements or herbal products.
  • Tell your doctor if you are pregnant, planning to become pregnant, or are breastfeeding. Use effective birth control to prevent pregnancy while on treatment with trandolapril.
  • Tell your doctor that you are taking trandolapril if you are planning to have surgery, including dental surgery.
  • Do not drive a vehicle or do activities that require alertness while being treated with trandolapril, because this drug can cause dizziness.
  • See a doctor immediately if you have an allergic drug reaction , overdose, or serious side effects after taking trandolapril.

Dosage and Rules for Using Trandolapril

The dosage prescribed by the doctor depends on the condition and age of the patient. The following is the dose of trandolapril for adults based on the purpose of treatment:

  • Purpose: Treatment of hypertension . The
    dose is 0.5 mg, once a day. Maintenance dose 1–2 mg once daily. The dose can be increased to 4 mg per day which is divided into 1-2 consumption schedules.
  • Purpose: Treatment after a heart attack
    The dose is 0.5 mg, 1 time a day. Treatment will start 3 days after the heart attack. Dosage can be increased to 4 mg, once a day.

How to Take Trandolapril Properly

Follow the doctor 's recommendations and read the instructions on the drug packaging before taking trandolapril. Do not reduce or increase your dose without consulting your doctor.

Take trandolapril regularly at the same time every day for maximum treatment effect. Trandolapril can be taken before or after meals.

If you forget to take trandolapril, consume it immediately if the break with the next consumption schedule is not too close. If it's close, ignore it and don't double the dose.

One of the side effects that can occur after consuming trandolapril is dizziness. Therefore, do not rush to get up after you have taken trandolapril.

To help keep blood pressure under control, you are also advised to exercise regularly, limit salt consumption, eat healthy foods, and maintain an ideal body weight.

Store trandolapril in its packaging in a cool, dry place and avoid exposure to direct sunlight. Keep this drug out of reach of children.

Interactions of Trandolapril with Other Drugs

Some of the drug interaction effects that can occur if trandolapril is used with certain drugs include:

  • Increased risk of developing hyperkalemia when used with potassium-sparing diuretics or potassium supplements
  • Increased risk of developing hypoglycemia when used with anti-diabetic drugs, such as glimepiride or glyburide
  • Increased risk of lithium poisoning
  • Increased risk of impaired kidney function when used with non-steroidal anti-inflammatory drugs (NSAIDs)

In addition, if trandolapril is taken with liquorice ( licorice ), more severe hypertension can occur.

Trandolapril Side Effects and Dangers

Side effects that can occur after using trandolapril include:

  • Dry cough
  • Fatigue
  • Dizziness or feeling lightheaded
  • Muscle ache

Check with your doctor if these side effects don't go away or get worse. Immediately see a doctor if you experience an allergic drug reaction or experience serious side effects, such as:

  • Hyperkalemia , which can be marked by symptoms such as muscle weakness, irregular heartbeat, or fainting
  • Kidney disease, which can be characterized by symptoms in the form of a very small amount of urine or urinating infrequently
  • Fever , chills, or sore throat that doesn't go away
  • Liver disease, which can be characterized by symptoms such as nausea or vomiting that doesn't get better, loss of appetite, dark urine, or jaundice
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