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Ursodeoxycholic Acid

Ursodeoxycholic Acid

Ursodeoxycholic acid or ursodeoxycholic acid is a medication to treat inoperable small gallstones and prevent the formation of gallstones in obese patients who are undergoing weight loss.

Ursodeoxycholic acid is a bile acid derivative that works by reducing the amount of cholesterol produced by the liver and absorbed by the digestive tract. This drug is also used to treat primary biliary cholangitis .

ursodeoxycholic acid - alodokter

Trademarks of ursodeoxycholic acid : Deolit, Estazor, Urdafalk, Urdahex, Urdex, Urlicon, Ursolic, Ursochol 300, Ursodeoxycholic Acid

What is Ursodeoxycholate

group Prescription drug
Category Bile acid derivatives
Benefit Overcoming small gallstones, preventing the formation of gallstones in obese patients, and treating primary biliary cholangitis .
Consumed by Mature
Ursodeoxycholic acid for pregnant and lactating women Category B:  Animal studies have not demonstrated a risk to the fetus, but there are no controlled studies in pregnant women. Whether ursodeoxycholic acid is absorbed into breast milk is not known. If you are breastfeeding, do not use this medicine without consulting your doctor first.
Drug form Tablets and capsules

Precautions Before Consuming  Ursodeoxycholic Acid

Ursodeoxycholic acid should only be used as prescribed by a doctor. Before consuming ursodeoxycholic acid, you need to pay attention to the following things:

  • Do not use ursodeoxycholic acid if you are allergic to this drug. Tell your doctor about any history of allergies you have.
  • Tell your doctor if you are taking certain supplements, herbal products, or medications, including ciclosporin, colestyramine, antacids, and birth control pills .
  • Tell your doctor if you have an obstruction in your liver and gallbladder. Ursodeoxycholic acid should not be used under these conditions.
  • While undergoing treatment with ursodeoxycholic acid, your doctor will ask you to periodically perform liver function tests and complete blood counts.
  • Tell your doctor if you have or have ever had liver disease , gallbladder disorders, other than gallstones, colitis , cough or bloody vomiting , or have recently had surgery on the digestive tract.
  • See your doctor right away if you have an overdose, drug allergic reaction, or serious side effects after taking ursodeoxycholic acid.

Dosage and Instructions for Use of Ursodeoxycholic Acid

The doctor will determine the dosage and duration of treatment with ursodeoxycholic acid according to the patient's condition. The following is the distribution of ursodeoxycholic acid doses based on their intended use:

  • Purpose: Treating gallstones
    The dose is 8-12 mg/kgBW, 1 time a day before bedtime or divided into 2 consumption schedules, treatment is carried out for 3-4 months. In obese patients, the dose is 15 mg/kg body weight per day.
  • Objective: To prevent the formation of gallstones in obese patients who are losing weight
    The dose is 300 mg, 2 times a day.
  • Purpose: To treat primary biliary cholangitis
    . The dose is 10–16 mg/kgBW per day divided into 2–4 consumption schedules, or it can be taken once a day at night after the first 3 months.

How to Take Ursodeoxycholic Acid Correctly

Make sure you first read the instructions on the medicine package and follow the doctor 's recommendations for taking ursodeoxycholic acid. Do not increase or decrease the dose without consulting your doctor first.

Take ursodeoxycholic acid regularly at the same time every day. Ursodeoxycholic acid can be taken before bed. Swallow the medicine with the help of a glass of water. Swallow the medicine whole, do not chew or crush it.

If you forget to take ursodeoxycholic acid, take it immediately if the break with the next consumption schedule is not too close. If it's close, ignore it and don't double the dose.

Ursodeoxycholic acid will usually be taken in the long term. Take control and follow the doctor's advice while undergoing treatment with ursodeoxycholic acid. Do not stop treatment without consulting your doctor first.

Store ursodeoxycholic acid in a dry, closed place, and avoid exposure to direct sunlight. Keep medicine out of reach of children.

Ursodeoxycholic Acid Interaction  with Other Drugs

The use of certain drugs together with ursodeoxycholic acid can cause unwanted interactions, such as:

  • Decreased absorption of ursodeoxycholic acid when used with cholestyramine or  antacids
  • Increased effectiveness of the drug ciclosporin
  • Decreased effectiveness of ursodeoxycholic acid when used with clofibrate drugs, birth control pills, or hormone drugs that contain estrogen

Ursodeoxycholic Acid Side Effects and Dangers

Side effects that may arise after consuming ursodeoxycholic acid are:

  • Pruritus or itching
  • Headache or dizziness
  • Stomach ache
  • Nausea, diarrhea , or constipation
  • Flu symptoms, such as stuffy nose or sneezing
  • Hair loss
  • Back pain

Check with your doctor if the complaint doesn't improve and gets worse. Immediately see a doctor if an allergic drug reaction occurs or more serious side effects occur, such as pain when urinating, bloody urine , fast heart rate, persistent vomiting, itching and redness all over the body, or unusual tiredness.

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