Vasopressin or vasopressin is a drug to treat diabetes insipidus. This medication will help reduce the frequency of urination and control thirst. In addition, this drug can also be used in the treatment of bleeding esophageal varices.

Vasopressin works by reducing the amount of urine produced by the kidneys and helping to constrict (vasoconstrict) blood vessels, thereby helping to regulate the frequency and amount of urine that comes out.

This drug also has the effect of triggering bowel movements, so it can be used to help with the X-ray process of the digestive tract.

Vasopressin trademark: Farpressin

What is Vasopressin

class Prescription drug
Category Hormone
Benefit Treating diabetes insipidus and bleeding from esophageal varices
Used by Mature
Vasopressin for pregnant and lactating women Category C:  Animal studies have shown an adverse effect on the fetus, but there have been no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

It is not known whether vasopressin is absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Form Injection fluid

Precautions Before Using Vasopressin

Vasopressin should not be used carelessly. Before using this drug, you need to pay attention to the following points:

  • Tell your doctor about any history of allergies you have. Vasopressin should not be used by patients who are allergic to this drug.
  • Tell your doctor if you have had or currently have coronary heart disease , kidney disease, asthma , migraines, epilepsy , seizures, or edema .
  • Tell your doctor if you are taking certain medications, supplements or herbal products.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy.
  • Immediately see a doctor if you have an allergic reaction to the drug, serious side effects, or an overdose after using vasopressin.

Dosage and Rules for Using Vasopressin

The doctor will give the dose and determine the duration of treatment according to the patient's condition. Vasopressin is only available in injection form and can be injected into a vein (intravenously/IV), into a muscle (intramuscular/IM), or under the skin (subcutaneously/SC).

The following is a distribution of vasopressin doses based on the condition you want to treat:

  • Condition:  Diabetes insipidus
    5–20 units, given by SC/IM, 2–3 times daily.
  • . Condition: Bleeding of esophageal varices
    Dose 20 units, dissolved in 100 ml glucose 5% infusion over 15 minutes.

How to Use Vasopressin Properly

Vasopressin will be injected by a doctor or medical officer under the supervision of a doctor. This drug will be injected into a vein (intravenous/IV), into a muscle (intramuscular/IM), or under the skin (subcutaneous/SC).

During therapy with vasopressin, your doctor will determine the amount of fluid you should consume, to avoid excess or lack of fluids.

In addition, you will also routinely undergo heart record checks or EKGs to monitor heart function. Follow the doctor's recommendations while undergoing therapy with vasopressin.

Interactions of Vasopressin with Other Drugs 

The use of vasopressin with other drugs can cause drug interaction effects, including:

  • Increased effectiveness of vasopressin when used with carbamazepine , fludrocortisone, chlorpropamide, clofibrate, or tricyclic antidepressant drugs
  • Decreased effectiveness of vasopressin when used with demeclocycline, noradrenaline, lithium , or heparin
  • Increased risk of heart rhythm disturbances, ie QT prolongation syndrome when used with dolasetron, clozapine , or amiodarone
  • Increased risk of fluid retention and low blood sodium levels when used with indomethacin or ibuprofen

Vasopressin Side Effects and Dangers

Some of the side effects that can arise after using vasopressin are:

  • Pale
  • Nausea or vomiting
  • Stomach cramps or bloating
  • Excessive sweating
  • Shiver
  • Headache

Check with your doctor if the side effects above don't go away or get worse. Immediately see a doctor if you experience an allergic drug reaction or more serious side effects, such as:

  • Shortness of breath, chest pain, slow , or irregular heart rate
  • Severe dizziness or unusual tiredness
  • Numbness or tingling in hands or feet
  • Hyponatremia which can be characterized by symptoms such as headaches, confusion, vomiting, or loss of balance
  • Water poisoning which can be characterized by symptoms such as severe throbbing headaches, drowsiness, or the body feels very weak
  • Fainting or seizures
Back to blog